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Isopropyl Myristate
Isopropyl Myristate is a clear, colorless, and oily liquid ester formed by the reaction of isopropyl alcohol and myristic acid. It has a mild, pleasant odor and excellent spreading properties. IPM is widely used in cosmetics, pharmaceuticals, and industrial applications as an emollient, solvent, and penetration enhancer due to its ability to improve texture and absorption of topical formulations.
Isopropyl Myristate (IPM)
Primary Uses
- Cosmetic and Personal Care Industry
- Used as an emollient and moisturizer in creams, lotions, sunscreens, deodorants, and makeup products for smooth, non-greasy skin feel.
- Functions as a penetration enhancer facilitating deeper delivery of active ingredients through the skin.
- Acts as a solvent for fragrances, oils, and other cosmetic ingredients improving formulation stability and texture.
- Pharmaceutical Industry
- Utilized in topical creams, ointments, and gels to improve absorption of drugs through the skin.
- Used as a vehicle for transdermal drug delivery systems.
- Fragrance and Perfume Industry
- Serves as a solvent and fixative to improve scent dispersion and longevity in perfumes and colognes.
- Industrial Applications
- Applied as a lubricant and anti-static agent in textile, plastics, and rubber industries.
- Used in formulations of insect repellents and pesticide carriers.
Secondary Uses
- Food Industry
- Occasionally used as a flavor carrier or additive in specific food-grade applications (subject to regulatory approval).
- Hair Care Products
- Added to shampoos, conditioners, and styling products to enhance smoothness and reduce greasy residue.
- Cleaning and Polishing Products
- Used in specialized cleaning formulations and polishes for its lubricating and spreading properties.
- Veterinary Applications
- Employed in topical formulations for animals as a skin conditioner and drug delivery enhancer.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Propan-2-yl tetradecanoate
- Common/Trade Name: Isopropyl Myristate; IPM
- CAS Number: 110-27-0
- HS Code: 2915.70.00
- Synonyms: Isopropyl tetradecanoate; IPM
2. Physical & Chemical Properties
- Physical State: Clear oily liquid
- Color & Odor: Colorless; mild, pleasant odor
- Boiling Point: 280–285 °C
- Melting Point: −9 °C
- Density: 0.86 g/cm³ (approx.)
- Solubility: Insoluble in water; soluble in most organic solvents
- Flash Point: 118 °C
3. Safety & Hazard Attributes
GHS Classification:
- Not classified as hazardous under typical use
- May cause mild skin or eye irritation in sensitive individuals
Toxicity:
- Low toxicity; generally regarded as safe in cosmetic and pharmaceutical use
Exposure Limits:
- No established occupational exposure limits
4. Storage & Handling Attributes
Storage Conditions:
- Store in a cool, dry, well-ventilated area away from strong oxidizers
Container Type:
- Stored in tightly sealed plastic or metal containers
Shelf Life:
- Stable for 2–3 years if stored properly
Handling Precautions:
- Avoid prolonged skin contact and inhalation of vapors
- Use appropriate PPE when handling in bulk
5. Regulatory & Compliance Attributes
- Approved for use in cosmetics and pharmaceuticals by FDA, EMA, and other regulatory bodies
- Complies with REACH and other chemical safety standards
- Must be labeled according to cosmetic ingredient regulations
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable
- Ecotoxicity: Low toxicity to aquatic organisms
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic
Safety Handling Precautions
PPE Required:
- Gloves and goggles recommended during handling of bulk material
Handling Guidelines:
- Avoid direct skin and eye contact
- Ensure adequate ventilation during use
Storage Measures:
- Keep containers tightly closed and away from heat sources
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash thoroughly with soap and water; if irritation develops, get medical advice
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical attention if irritation persists
- Ingestion: Rinse mouth and seek medical advice if significant amounts ingested
Firefighting Measures
- Fire Hazards: Combustible liquid; may burn but with low flame spread
- Extinguishing Media: Use foam, dry chemical, or COâ‚‚ extinguishers
- Special Precautions: Wear full protective gear and self-contained breathing apparatus if involved in fire
- Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and other toxic fumeS
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