Phloretin Extra Pure

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SHORT DESCRIPTION

Phloretin Extra Pure is a high-grade dihydrochalcone flavonoid renowned for its antioxidant, anti-inflammatory, and skin-penetration-enhancing properties. Derived from apples and certain other fruits, this compound appears as a pale-yellow crystalline powder and is sparingly soluble in water but dissolves well in ethanol and other organic solvents.

In cosmetic and dermatological applications, Phloretin is used to combat oxidative stress, brighten skin tone, and reduce the appearance of fine lines, pigmentation, and UV-induced damage. It also enhances the absorption of active ingredients across the skin barrier, making it a valuable addition to advanced skincare formulations.

In laboratory and pharmaceutical settings, it is utilized for research into cell signaling, anti-cancer mechanisms, and metabolic modulation, given its biological activity on various enzyme systems.

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Category: LABORATORY CHEMICALS Tags: AntioxidantResearch, BiochemicalReagent, CellStudies, HighPurityCompound, MolecularBiology, Phloretin, SpecialtyChemicals

Description

USES

PRIMARY USES

Used as a potent antioxidant in skincare formulations to protect against oxidative stress and free radical damage.
Serves as an anti-aging ingredient in serums and creams by improving skin tone, reducing wrinkles, and enhancing elasticity.
Employed in cosmetic science for its ability to inhibit melanin production, promoting skin brightening and reducing hyperpigmentation.
Applied in pharmaceutical research as a bioactive flavonoid with anti-inflammatory and anticancer properties.
Functions as a transdermal penetration enhancer, improving the absorption of active ingredients through the skin barrier.

SECONDARY USES

Investigated in nutraceuticals and supplements for potential metabolic and cardiovascular health benefits.
Studied in oncological research for its role in inhibiting cancer cell proliferation and inducing apoptosis.
Used in neuroscience research for its potential neuroprotective effects in oxidative-stress-related disorders.
Explored in antibacterial studies due to its capability to disrupt bacterial membranes and inhibit growth.
Considered in plant physiology and agricultural biochemistry for its natural role in apple and pear phenolics.

KEY PRODUCT FEATURES

KEY ATTRIBUTES

1. Basic Identification Attributes

Chemical Name: Phloretin
CAS Number: 60-82-2
HS Code: 2932.99.90
Molecular Formula: C₁₅H₁₄O₅
Synonyms:
- Dihydronaringenin
- (2R,3R)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
- Phloretol

2. Physical & Chemical Properties

Physical State: Solid (powder or crystalline)
Color & Odor: White to pale yellow; odorless or faint odor
Boiling Point: Decomposes before boiling
Melting Point: ~265–270 °C
Density/Specific Gravity: ~1.4 g/cm³ (estimated)
Solubility:
- Slightly soluble in water
- Soluble in ethanol, DMSO, and other organic solvents
pH Level: Neutral in pure state; slightly acidic in aqueous solution
Vapor Pressure: Negligible (non-volatile)
Flash Point: Not flammable under normal conditions
Autoignition Temperature: Not readily available
Viscosity: Not applicable (solid form)

3. Safety & Hazard Attributes

Hazard Class (GHS Classification):
- Not classified as hazardous under GHS for typical laboratory use
NFPA Ratings:
- Health: 1
- Flammability: 0
- Reactivity: 0
Exposure Limits:
- No established OSHA PEL or ACGIH TLV
Reactivity:
- Stable under standard conditions
- Avoid strong oxidizing agents

4. Storage & Handling Attributes

Storage Conditions:
- Store in a cool, dry place, away from direct light
- Tightly sealed container; avoid humidity
Incompatible Materials:
- Strong oxidizers, strong acids
Container Type: Amber glass or HDPE plastic with desiccant
Shelf Life & Expiration Date: 2–3 years if properly stored
Special Handling Requirements:
- Use gloves, lab coat, and protective eyewear
- Avoid inhalation of dust

5. Regulatory & Compliance Attributes

Regulatory Status:
- Not listed as a controlled substance
- Approved for cosmetic and research use in many regions
Hazard Symbols (GHS Pictograms):
- None required under normal classification
Transportation Restrictions:
- Not classified as dangerous for transport
Waste Disposal Method:
- Dispose of in accordance with local environmental regulations
- Avoid release into water systems

6. Environmental & Health Impact

Ecotoxicity:
- Low toxicity to aquatic organisms
Persistence in Environment:
- Biodegradable under natural conditions
Carcinogenicity/Mutagenicity:
- Not listed as carcinogenic by IARC, NTP, or OSHA
Biodegradability:
- Readily biodegradable

SAFETY HANDLING PRECAUTIONS

SAFETY PRECAUTIONS

Personal Protective Equipment (PPE):

Wear a lab coat, chemical-resistant gloves (e.g., nitrile), and safety goggles.
Use in a fume hood or well-ventilated area to avoid inhalation of dust.

Handling:

Avoid contact with skin, eyes, and clothing.
Do not ingest or inhale.
Minimize dust generation.
Practice good industrial hygiene—wash hands thoroughly after use.

Storage:

Store in a tightly sealed container in a cool, dry, and well-ventilated area.
Protect from light and moisture.
Keep away from incompatible substances like strong oxidizers.

FIRST AID MEASURES

Inhalation:

Move the person to fresh air.
Provide oxygen or artificial respiration if breathing is difficult.
Seek medical advice if symptoms persist.

Skin Contact:

Wash the affected area with plenty of soap and water.
Remove contaminated clothing.
Get medical help if irritation occurs.

Eye Contact:

Rinse immediately with plenty of water for at least 15 minutes.
Seek medical attention if irritation persists.

Ingestion:

Rinse mouth with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical attention immediately.

FIRE FIGHTING MEASURES

Flammability:

Not highly flammable, but combustible as a fine powder.

Extinguishing Media:

Use dry chemical powder, CO₂, foam, or water spray.

Hazardous Combustion Products:

Emits carbon monoxide (CO), carbon dioxide (CO₂), and other toxic fumes upon decomposition.

Firefighter Protection:

Wear self-contained breathing apparatus (SCBA) and full protective gear.
Avoid inhalation of combustion gases.