Formaldehyde Extra Pure

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SHORT DESCRIPTION

Formaldehyde Extra Pure is a highly concentrated and refined aqueous solution of formaldehyde gas, commonly used in laboratories, industrial processes, and research applications. Renowned for its potent disinfectant and preservative properties, it is widely employed in histology for tissue fixation, in microbiology for sterilization, and in various chemical syntheses as a versatile reagent and building block. Its extra pure grade ensures minimal impurities, making it suitable for sensitive analytical procedures, formulation work, and high-precision chemical reactions. This product must be handled with care due to its volatility and toxic nature, especially in enclosed environments.

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Category: LABORATORY CHEMICALS Tags: EnvironmentalAnalysis, Formaldehyde, Formalin, HistologyReagent, PreservativeTesting, ProteinCrosslinking, TissueFixative

Description

USES

Table of Contents

Primary Laboratory Uses:

Tissue fixation in histology and pathology:
Formaldehyde is widely used as a fixative to preserve biological tissues by cross-linking proteins, preventing decay and maintaining cellular structure for microscopic examination.
Reagent in synthesis and chemical reactions:
Serves as a precursor or intermediate in organic synthesis, particularly for producing resins (e.g., phenol-formaldehyde) and various laboratory-grade chemicals.

Secondary Laboratory Uses:

Disinfectant and sterilizing agent:
Used in controlled lab environments to sterilize surfaces, equipment, and biosafety cabinets, especially in microbiology and pathology labs.
Standard solution preparation:
Employed in the preparation of calibration standards or titration reagents in analytical chemistry.
DNA and RNA crosslinking studies:
Utilized in molecular biology for crosslinking nucleic acids and proteins during chromatin immunoprecipitation (ChIP) assays.

KEY PRODUCT FEATURES

KEY ATTRIBUTES

1. Basic Identification Attributes

Chemical Name: Formaldehyde
Chemical Formula: CH₂O
CAS Number: 50-00-0
Molecular Weight: 30.03 g/mol
Grade: Extra Pure (Laboratory Reagent Grade)
Physical State: Usually supplied as a 37–40% aqueous solution (formalin)
Appearance: Clear, colorless liquid
Odor: Strong, pungent, irritating odor

2. Physical & Chemical Properties

Boiling Point: ~96 °C (aqueous solution)
Melting Point: −92 °C (pure gas)
Solubility: Miscible with water, alcohol, and other polar solvents
Vapor Pressure: High at room temperature
pH: Typically acidic (around 3.5–5.5 for formalin)
Stability: Stable in aqueous solution with methanol stabilizer

3. Safety & Hazard Attributes

Hazard Classification: Toxic, Carcinogenic, Corrosive
GHS Symbols: ☠️ (Toxic), ⚠️ (Health Hazard), 🧪 (Corrosive)
Hazard Statements:
- H301: Toxic if swallowed
- H331: Toxic if inhaled
- H311: Toxic in contact with skin
- H350: May cause cancer
- H317: May cause allergic skin reaction
- H314: Causes severe skin burns and eye damage
PPE Requirements:
- Nitrile or butyl rubber gloves
- Lab coat and chemical-resistant apron
- Full-face shield or safety goggles
- Use only in a certified fume hood
First Aid Measures:
- Inhalation: Move to fresh air, seek medical help
- Skin Contact: Wash with plenty of soap and water
- Eye Contact: Rinse cautiously with water for 15 minutes
- Ingestion: Rinse mouth, do NOT induce vomiting, get medical help immediately

4. Storage & Handling Attributes

Storage Conditions:
- Keep in tightly sealed containers
- Store in a cool, well-ventilated place away from direct sunlight
- Avoid sources of ignition and oxidizing agents
Handling Notes:
- Always use with adequate ventilation
- Do not mix with acids or strong oxidizers
- Avoid breathing vapors

5. Regulatory & Compliance Attributes

UN Number: UN1198 (for formalin)
Regulatory Status:
- Listed as a carcinogen by IARC and NTP
- Regulated under OSHA, REACH, and other chemical safety standards
- Restricted use in food, cosmetics, and consumer products

6. Laboratory Applications

Primary Uses:
- Fixative in histology and pathology (tissue preservation)
- Disinfectant in laboratories
- Synthesis of resins (e.g., urea-formaldehyde)
- Reagent in analytical chemistry
Secondary Uses:
- Embalming fluid component
- Preservative in biological specimens
- Crosslinking agent for proteins and nucleic acids in molecular biology

SAFETY HANDLING PRECAUTIONS

SAFETY PRECAUTIONS

Personal Protective Equipment (PPE):

Wear lab coat, nitrile gloves, and chemical splash goggles.
Use in a well-ventilated area or fume hood to avoid inhalation.
Face shield may be necessary for large volume handling.

Handling:

Avoid contact with skin, eyes, and clothing.
Prevent inhalation of vapors or mists.
Do not eat, drink, or smoke when handling.
Handle with care as formaldehyde is toxic and a suspected carcinogen.

Storage:

Store in a cool, well-ventilated area away from direct sunlight.
Keep container tightly closed and away from acids, bases, and oxidizers.
Use only non-metallic containers if long-term storage is needed.
Label clearly and lock if required.

FIRST AID MEASURES

Inhalation:

Remove the victim to fresh air immediately.
If breathing is difficult, administer oxygen.
Seek urgent medical attention.

Skin Contact:

Immediately wash with plenty of water and soap for at least 15 minutes.
Remove contaminated clothing and shoes.
Seek medical attention if irritation or pain persists.

Eye Contact:

Rinse thoroughly with water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing and seek immediate medical attention.

Ingestion:

Rinse mouth with water.
Do NOT induce vomiting.
Seek immediate medical attention.

FIRE FIGHTING MEASURES

Flammability:

Flammable liquid and vapor. Flash point ~60°C.
Vapors may form explosive mixtures with air.

Extinguishing Media:

Use alcohol-resistant foam, dry chemical, or carbon dioxide (CO₂).
Water spray can be used to cool containers but may spread fire if used directly.

Hazardous Combustion Products:

Emits toxic fumes including carbon monoxide (CO), carbon dioxide (CO₂), and formaldehyde vapors.

Firefighter Protection:

Use self-contained breathing apparatus (SCBA) and full protective gear.
Approach fire from the upwind direction and avoid inhaling fumes.