Nicotinamide Extra Pure

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SHORT DESCRIPTION

Nicotinamide Extra Pure is a refined, high-purity form of vitamin B3, widely recognized for its essential role in human and animal health. It serves as a vital component in the synthesis of NAD⁺ and NADP⁺, coenzymes that are fundamental to numerous metabolic and enzymatic reactions in living cells. In laboratory settings, it is frequently used in biochemical research, cell culture media, and vitamin assays due to its stable and bioactive nature.

In pharmaceutical applications, nicotinamide is commonly used in the formulation of supplements and dermatological treatments, where it supports skin barrier function, reduces inflammation, and helps alleviate acne and hyperpigmentation. Its presence in cosmetic products is valued for promoting smoother, more even-toned skin. The Extra Pure grade guarantees minimal impurities, making it ideal for sensitive applications in health care, research, and personal care products. It should be stored in a cool, dry environment away from light to maintain its integrity.

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Category: LABORATORY CHEMICALS Tags: BiochemicalReagent, CellCulture, EnzymeCofactor, ExtraPure, LabGrade, MolecularBiology, NADPrecursor, Niacinamide, Nicotinamide, VitaminB3

Description

USES

PRIMARY USES:

Vitamin B3 supplement in pharmaceuticals and nutraceuticals.
Skin-care formulations for anti-inflammatory and brightening effects.

SECONDARY USES:

Used in cell culture media in laboratories.
Intermediate in synthesis of coenzymes NAD and NADP.

KEY PRODUCT FEATURES

KEY ATTRIBUTES

1. Basic Identification Attributes

Chemical Name: Nicotinamide
CAS Number: 98-92-0
HS Code: 2936.26.00
Molecular Formula: C₆H₆N₂O
Synonyms:
- Niacinamide
- Vitamin B3 amide
- Pyridine-3-carboxamide
- 3-Pyridinecarboxamide

2. Physical & Chemical Properties

Physical State: Crystalline solid
Color & Odor: White, odorless powder
Boiling Point: Decomposes before boiling
Melting Point: 128–131 °C
Density: ~1.4 g/cm³
Solubility: Freely soluble in water, ethanol; slightly soluble in ether and chloroform
pH Level: ~6.0–7.5 (in 1% solution)
Vapor Pressure: Negligible
Flash Point: >160 °C (closed cup)
Autoignition Temperature: Not readily available
Viscosity: Not applicable (solid material)

3. Safety & Hazard Attributes

Hazard Class (GHS Classification): Not classified as hazardous
NFPA Ratings:
- Health: 1
- Flammability: 1
- Reactivity: 0
Exposure Limits: No OSHA PEL or ACGIH TLV established
Reactivity: Stable under normal conditions; avoid strong oxidizers

4. Storage & Handling Attributes

Storage Conditions:
- Store tightly sealed in a cool, dry, and well-ventilated area
- Protect from moisture and light
Incompatible Materials: Strong oxidizing agents
Container Type: Amber glass or HDPE containers
Shelf Life & Expiration Date: Typically 3–5 years if stored properly
Special Handling Requirements:
- Use standard PPE (gloves, goggles, lab coat)
- Minimize dust generation and inhalation

5. Regulatory & Compliance Attributes

Regulatory Status:
- Listed under FDA (GRAS), REACH, TSCA, and other regulatory inventories
Hazard Symbols (GHS Pictograms): None required
Transportation Restrictions: Not regulated (non-hazardous)
Waste Disposal Method: Dispose in accordance with local and national regulations; typically non-hazardous waste

6. Environmental & Health Impact

Ecotoxicity: Low toxicity to aquatic organisms
Persistence in Environment: Biodegradable
Carcinogenicity/Mutagenicity:
- Not listed as carcinogenic by IARC, NTP, or OSHA
Biodegradability: Readily biodegradable; low environmental persistence

SAFETY HANDLING PRECAUTIONS

SAFETY PRECAUTIONS

Personal Protective Equipment (PPE):

Wear a lab coat, nitrile gloves, and protective goggles.
Use a dust mask or work in a fume hood if dust generation is likely.

Handling:

Avoid contact with skin, eyes, and clothing.
Minimize dust formation; avoid inhaling airborne particles.
Wash hands thoroughly after handling.
Do not eat, drink, or smoke while using this product.

Storage:

Store in a tightly sealed container in a cool, dry, and well-ventilated place.
Keep away from strong oxidizing agents and direct sunlight.
Protect from moisture and excessive heat.

FIRST AID MEASURES

Inhalation:

Move the affected person to fresh air immediately.
Seek medical advice if symptoms such as coughing or shortness of breath develop.

Skin Contact:

Wash thoroughly with soap and water.
Remove any contaminated clothing.
Seek medical attention if irritation or discomfort persists.

Eye Contact:

Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing and consult a medical professional if irritation continues.

Ingestion:

Rinse mouth with water.
Do not induce vomiting.
Seek immediate medical attention if large amounts are swallowed or if discomfort occurs.

FIRE FIGHTING MEASURES

Flammability:

Not considered highly flammable, but combustible at high temperatures.

Extinguishing Media:

Use water spray, dry chemical, CO₂, or foam.
Avoid high-pressure water jets that may spread dust.

Hazardous Combustion Products:

May produce toxic gases such as nitrogen oxides and carbon oxides when burned.

Firefighter Protection:

Wear full protective gear and a self-contained breathing apparatus (SCBA).
Avoid exposure to fumes, and ventilate the area after fire suppression.