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Betamethasone 17 Valerate BP
Betamethasone 17 Valerate BP is a potent synthetic corticosteroid ester used primarily for its anti-inflammatory, antipruritic, and vasoconstrictive properties. It is commonly applied topically to treat a variety of skin conditions such as eczema, psoriasis, dermatitis, and allergic reactions. The valerate ester enhances the lipophilicity and skin penetration of betamethasone, improving its therapeutic efficacy. It is recognized in the British Pharmacopoeia (BP) for pharmaceutical standards and quality.
Betamethasone 17 Valerate BP
Primary UsesÂ
- Pharmaceutical & Dermatological Uses
- Used topically to treat inflammatory skin conditions including eczema, psoriasis, and contact dermatitis.
- Alleviates symptoms such as redness, itching, swelling, and discomfort caused by allergic reactions and insect bites.
- Employed in corticosteroid formulations like creams, ointments, lotions, and gels for localized anti-inflammatory effect.
- Often used as a second-line treatment for moderate to severe dermatological disorders where mild corticosteroids are ineffective.
- Veterinary Medicine
- Used in veterinary topical treatments for inflammatory skin conditions in animals under veterinary supervision.
Secondary Uses
- Occasionally included in combination pharmaceutical products with antifungal or antibacterial agents for treating mixed infections with inflammatory symptoms.
- Used in clinical research for studying corticosteroid effects and delivery systems in dermatology.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
- Common/Trade Names: Betamethasone 17 Valerate, Betamethasone valerate, BMV
- CAS Number: 2152-44-5
- HS Code: 2937.29.00
- Molecular Formula: C27H37FO6
- Synonyms: Betamethasone valerate, Betamethasone 17-valerate, 17-Valerate ester of betamethasone
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White or creamy, odorless or faint odor
- Melting Point: 118–121°C
- Solubility: Slightly soluble in water, soluble in alcohol, chloroform, and acetone
- Stability: Stable under recommended storage; sensitive to light and moisture
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous but may cause skin irritation or sensitization
- NFPA Ratings: Health 2, Flammability 1, Reactivity 0
- Exposure Limits: No specific occupational exposure limits established
- Toxicity: Low systemic toxicity when used topically as directed; prolonged use may cause steroid-related side effects
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light and moisture
- Container Type: Airtight containers, usually amber glass or plastic tubes for formulations
- Shelf Life: 2–3 years under proper conditions
- Special Handling: Avoid exposure to heat, light, and moisture; use PPE to avoid direct skin contact with pure powder
5. Regulatory & Compliance Attributes
- BP (British Pharmacopoeia): Officially recognized and monographed
- FDA/EMA: Approved in many countries for topical corticosteroid formulations
- Transportation: Not classified as hazardous
- Waste Disposal: Dispose as pharmaceutical waste according to local regulations
6. Environmental & Health Impact
- Ecotoxicity: Low environmental hazard when used properly
- Persistence: Degrades in the environment, but prolonged exposure should be minimized
- Carcinogenicity: Not classified as carcinogenic
- Biodegradability: Moderately biodegradable
Safety Handling Precautions
- PPE: Wear gloves, protective clothing, and eye protection when handling the pure chemical.
- Avoid: Prolonged skin contact and inhalation of dust.
- Ventilation: Work in well-ventilated areas.
- Hygiene: Wash hands thoroughly after handling.
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms persist.
- Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs.
- Eye Contact: Rinse with plenty of water for 15 minutes; seek medical attention if irritation persists.
- Ingestion: Rinse mouth and seek medical advice.
Firefighting Measures
- Fire Hazards: Combustible solid; may burn but not easily ignited.
- Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguishers.
- Special Precautions: Firefighters should wear protective equipment and self-contained breathing apparatus.
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