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Sulphadoxine
Sulphadoxine BP is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.
Sulphadoxine
Primary Uses
- Human Medicine
- Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.
- Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.
- Veterinary Medicine
- Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.
Secondary Uses
- Research & Development
- Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.
- Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.
- Public Health Programs
- Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- Common/Trade Name: Sulphadoxine BP 98
- CAS Number: 2447-57-6
- HS Code: 2941.20.00
- Synonyms: Sulfadoxine, Sulphadoxine
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: White; odorless to faint sulfur-like odor
- Melting Point: 190–194 °C
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents
- Density: Approx. 1.5 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions
- Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome
- Exposure Limits: No specific occupational limits; handle with care
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under recommended storage conditions
- Handling Precautions: Avoid dust generation; use PPE such as gloves and masks
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Approved for use in antimalarial combination therapies by relevant regulatory authorities
6. Environmental & Health Impact
- Biodegradability: Limited biodegradability under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, protective clothing, and dust masks recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth and seek medical advice promptly
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Dicyclomine Hydrochloride
Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.
Diloxanide Furoate
Diloxanide Furoate is an orally administered antiprotozoal agent used primarily for the treatment of amoebiasis. It is a furan-based derivative that acts as a luminal amoebicide, effectively targeting Entamoeba histolytica cysts and trophozoites within the intestinal lumen. This compound is well-regarded for its efficacy in eradicating asymptomatic cyst carriers and as a follow-up treatment after systemic amoebicidal therapy. Diloxanide Furoate has good oral bioavailability and a favorable safety profile.
Doxycycline Hyclate BP
Doxycycline Hyclate BP is a broad-spectrum, semisynthetic tetracycline-class antibiotic available as the hemihydrate salt form of doxycycline. It is widely used in pharmaceutical formulations due to its high bioavailability, broad antibacterial activity, and favorable pharmacokinetic profile. The compound exhibits bacteriostatic action by inhibiting protein synthesis in susceptible bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms as well as atypical pathogens. It is typically supplied as a fine, white to off-white crystalline powder soluble in water and suitable for oral and parenteral dosage forms.
Enrofloxacin Hydrochloride
Enrofloxacin Hydrochloride is a broad-spectrum fluoroquinolone antibiotic used primarily in veterinary medicine. It is the hydrochloride salt of enrofloxacin, offering enhanced solubility and bioavailability. Enrofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication in Gram-negative and Gram-positive organisms as well as some Mycoplasma species. It is available as a white to off-white crystalline powder, used in injectable, oral, and topical formulations designed for livestock, companion animals, and aquatic species.
Gentamycin Sulphate
Gentamycin Sulphate is an aminoglycoside antibiotic derived from Micromonospora purpurea and Micromonospora griseorubida. It appears as a white or off-white crystalline powder, highly soluble in water, with a characteristic aminoglycoside odor. Gentamycin Sulphate is widely used in human and veterinary medicine for its broad-spectrum bactericidal activity against aerobic Gram-negative and some Gram-positive bacteria. It works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, leading to bacterial cell death. Due to its effectiveness against severe infections and multi-drug resistant strains, it is an essential antibiotic in clinical settings.
Mepyramine Maleate BP
Mepyramine Maleate BP is an antihistamine drug commonly used to relieve allergic symptoms such as hay fever, urticaria, and other allergic reactions. It works by blocking histamine H1 receptors, reducing allergic responses like itching, swelling, and redness. This compound is a white or off-white crystalline powder, soluble in water and alcohol, widely used in pharmaceutical formulations including tablets, creams, and injectables.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
