Beta Arbutin Extra Pure

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Beta Arbutin Extra Pure is a high-purity, white crystalline powder primarily used in laboratory research involving biochemical, pharmaceutical, and cosmetic studies. It is a glycosylated hydroquinone known for its role as a tyrosinase inhibitor, making it significant in the investigation of melanin biosynthesis and skin depigmentation mechanisms. In pharmaceutical and cosmetic research, it is often evaluated for its antioxidant properties and potential therapeutic applications in skin-lightening formulations. The extra pure grade ensures high chemical stability and minimal impurities, supporting reliable results in sensitive assays and analytical procedures. It should be stored in a cool, dry environment, protected from light and moisture.

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Description

USES

Primary Uses

Standard in Skin Depigmentation Studies
- Used as a reference compound in dermatological and pharmaceutical labs for evaluating melanin inhibition and tyrosinase enzyme activity.
Biochemical Assays
- Utilized in enzyme kinetics experiments to study tyrosinase inhibition mechanisms — key in melanogenesis research.
Chromatography Reference Standard
- Applied in HPLC, TLC, and LC-MS as a standard or analyte for separation and quantification of phenolic compounds in plant extracts or cosmetic formulations.
Cell Culture and Cytotoxicity Testing
- Employed in in vitro cell culture studies to examine its cytotoxicity, antioxidant capacity, and influence on melanocytes or keratinocytes.

Secondary Uses

Antioxidant Studies in Life Science Labs
- Used as a model compound to study free radical scavenging, antioxidant pathways, or oxidative stress responses.
Phytochemical Screening
- Appears as a marker compound in the qualitative or quantitative analysis of plant-based ingredients, especially in herbal cosmetics.
Teaching Functional Group Chemistry
- Useful in demonstrating glycosidic bond cleavage, phenolic reactivity, and structure–activity relationships in higher-level organic chemistry education.
Comparison in Cosmetic Formulation Testing
- In research labs, it may be used to compare efficacy, safety, and penetration of active agents in formulation prototypes.

Product Key Features

KEY ATTRIBUTES

1. Basic Identification Attributes

Chemical Name: Hydroquinone β-D-glucopyranoside
Common Name: Beta Arbutin
CAS Number: 497-76-7
HS Code: 2938.90.90
Molecular Formula: C₁₂H₁₆O₇
Molar Mass: 272.25 g/mol
Synonyms:
- β-Arbutin
- Arbutoside
- 4-Hydroxyphenyl β-D-glucopyranoside
- Arbutin (when beta form is implied)

2. Physical & Chemical Properties

Physical State: Solid
Color & Odor: White crystalline powder, odorless
Boiling Point: Decomposes before boiling
Melting Point: ~195–197 °C
Density: ~1.55 g/cm³ (estimated)
Solubility:
- In Water: Freely soluble
- In Alcohols: Soluble in ethanol and methanol
pH (1% solution): ~5.0–7.0
Vapor Pressure: Negligible (non-volatile)
Flash Point: Not applicable (non-flammable solid)
Autoignition Temperature: Not readily flammable
Viscosity: Not applicable (solid)

3. Safety & Hazard Attributes

GHS Classification:
- Not classified as hazardous under normal lab conditions
NFPA Ratings:
- Health: 1
- Flammability: 0
- Reactivity: 0
Exposure Limits:
- Not established by OSHA or ACGIH
Reactivity:
- Stable under normal conditions
- May degrade under high heat or light
- Avoid strong oxidizers

4. Storage & Handling Attributes

Storage Conditions:
- Store in a cool, dry, dark place
- Avoid light and moisture exposure
Incompatible Materials:
- Strong oxidizers, acids
Container Type:
- Tightly sealed amber glass or HDPE bottles
Shelf Life:
- 2–3 years under ideal storage
Special Handling Requirements:
- Use gloves and goggles
- Handle in a clean, low-humidity environment

5. Regulatory & Compliance Attributes

Regulatory Status:
- Not specifically regulated as a hazardous chemical
- Used in cosmetics and analytical chemistry
Hazard Symbols (GHS pictograms):
- Not classified under GHS
UN Number: Not classified for transport as hazardous
Waste Disposal Method:
- Dispose according to local regulations as non-hazardous organic waste

6. Environmental & Health Impact

Ecotoxicity:
- Low aquatic toxicity at lab-use concentrations
Persistence in Environment:
- Biodegradable under natural conditions
Carcinogenicity/Mutagenicity:
- Not classified as carcinogenic
- May release hydroquinone upon metabolism, which is regulated
Biodegradability:

Readily biodegradable

Safety Handling Precautions

SAFETY PRECAUTIONS

Personal Protective Equipment (PPE):
- Wear lab coat, chemical-resistant gloves, and safety goggles.
- Use in a well-ventilated area or under a fume hood.
Handling:
- Avoid generating dust.
- Prevent contact with eyes, skin, and clothing.
- Do not inhale dust or vapors.
Storage:
- Store in a tightly closed container in a cool, dry place.
- Protect from light, moisture, and heat.
Hygiene Measures:
- Wash hands thoroughly after use.
- Avoid eating or drinking near chemical handling zones.

FIRST AID MEASURES

Inhalation:
- Move to fresh air.
- Seek medical attention if respiratory symptoms occur.
Skin Contact:
- Wash with soap and water.
- Remove contaminated clothing.
- Get medical attention if irritation persists.
Eye Contact:
- Rinse eyes with plenty of water for 15 minutes.
- Lift eyelids occasionally.
- Consult an eye specialist if irritation continues.
Ingestion:
- Rinse mouth with water.
- Do not induce vomiting.
- Seek medical advice immediately.

FIRE FIGHTING MEASURES

Extinguishing Media:
- Use dry chemical, foam, carbon dioxide (CO₂), or water spray.
Fire Hazards:
- Product may decompose at high temperatures forming toxic fumes (e.g., CO, CO₂).
Protective Equipment:
- Firefighters should wear self-contained breathing apparatus (SCBA) and full protective gear.
Additional Notes:
- Containers may rupture if exposed to fire or extreme heat.
- Prevent runoff from contaminating water sources.