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D-Panthenol USP
D-Panthenol USP, also known as Provitamin B5, is the dextrorotatory isomer of panthenol and is biologically active. It is a water-soluble, viscous, clear liquid with a slightly sweet odor and is widely used in pharmaceutical, cosmetic, personal care, and nutraceutical applications. D-Panthenol is the alcohol analog of pantothenic acid (Vitamin B5) and is converted into Vitamin B5 in the skin and body, where it plays a vital role in cellular metabolism and tissue repair. Its moisturizing, anti-inflammatory, and healing properties make it highly valuable across industries.
Description
D-Panthenol USP Uses
Primary UsesÂ
Cosmetics & Personal Care
- Used in skin care products (lotions, creams, serums) for its moisturizing, soothing, and anti-inflammatory properties.
- Improves skin hydration, reduces redness, and enhances skin barrier repair.
- Commonly found in shampoos, conditioners, and hair serums to improve hair strength, shine, and manageability.
- A key ingredient in baby care products due to its mildness and skin-healing benefits.
- Included in after-sun and burn relief products for its calming effects.
Pharmaceuticals
- Used in wound healing creams, ointments, and gels for its epithelialization-promoting and anti-inflammatory actions.
- Incorporated into nasal sprays, eye drops, and oral formulations for mucosal repair.
- Applied in burn and dermatitis treatment formulations.
- Serves as a humectant and skin protectant in topical drugs.
Nutraceuticals & Dietary Supplements
- Used in vitamin formulations and fortified beverages as a source of Vitamin B5.
- Supports adrenal function, cellular metabolism, and skin/mucosal health.
Secondary Uses
Veterinary Care
- Used in veterinary skin creams and hair products for animals to promote healing and coat health.
- Applied in topical ointments for livestock to treat minor wounds and dermatitis.
Industrial Applications
- Used in industrial skin-care formulations (e.g., barrier creams for workers).
- Added in formulations for protective creams used in occupational settings to treat or prevent irritant contact dermatitis.
Research & Biotechnology
- Utilized in cell culture media and tissue engineering applications due to its role in cellular repair and proliferation.
KEY ATTRIBUTES
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
- Common/Trade Name: D-Panthenol USP
- CAS Number: 81-13-0
- HS Code: 2936.26.00
- Molecular Formula: C9H19NO4
- Synonyms:
- Provitamin B5
- Dexpanthenol
- Pantothenol
2. Physical & Chemical Properties
- Physical State: Viscous liquid
- Color & Odor: Colorless to slightly yellow; mild, characteristic odor
- Melting Point: Not applicable (liquid form)
- Boiling Point: ~118–120°C at 0.15 mmHg
- Density: 1.145–1.160 g/cm³ at 20°C
- Solubility:
- Freely soluble in water and alcohol
- Insoluble in oils and hydrocarbons
- pH (10% solution): 5.0–7.0
- Stability: Stable under recommended storage; sensitive to high heat and oxidizing agents
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous
- NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
- Exposure Limits: No established limits; generally considered safe
- Toxicity: Non-toxic; well-tolerated on skin and mucosa
- Reactivity: Non-reactive; avoid contact with strong oxidizers
4. Storage & Handling Attributes
- Storage Conditions: Store in tightly sealed containers at 15–25°C, away from direct sunlight and heat
- Container Type: Amber glass or HDPE containers with airtight seals
- Shelf Life: Up to 3 years under optimal conditions
- Special Handling: Use clean, dry tools; protect from contamination and moisture
5. Regulatory & Compliance Attributes
- USP/NF Status: Complies with United States Pharmacopeia (USP) standards
- FDA Status: GRAS (Generally Recognized as Safe); approved for cosmetic and pharmaceutical use
- REACH Status: Registered under EU REACH
- Transportation: Not classified as hazardous for transport
- Waste Disposal: Dispose in accordance with local regulations; biodegradable and non-toxic
6. Environmental & Health Impact
- Ecotoxicity: Not toxic to aquatic or terrestrial life
- Persistence: Readily biodegradable
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: High; environmentally safe for disposal
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
Personal Protective Equipment (PPE):
- Nitrile gloves
- Protective eyewear
- Lab coat or apron
Handling Measures:
- Avoid inhalation of vapors or aerosols during processing
- Use in a well-ventilated area
- Avoid contact with incompatible substances
Storage Measures:
- Keep containers sealed and protected from light and air
- Store in original packaging or approved chemical storage containers
Hygiene Practices:
- Wash hands thoroughly after handling
- Avoid contact with eyes and broken skin
- Do not eat or drink in processing areas
First Aid Measures
- Inhalation: Not expected to pose inhalation hazard; move to fresh air if discomfort occurs
- Skin Contact: Generally non-irritating; rinse with water if needed
- Eye Contact: Rinse with water for several minutes; seek medical attention if irritation persists
- Ingestion: Non-toxic in small quantities; seek medical advice if large amounts are ingested
Firefighting Measures
- Fire Hazards: Slightly combustible
- Extinguishing Media: Use dry chemical, COâ‚‚, water spray, or foam
- Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus
- Decomposition Products: May release carbon oxides upon combustion
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