D-Panthenol USP

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D-Panthenol USP, also known as Provitamin B5, is the dextrorotatory isomer of panthenol and is biologically active. It is a water-soluble, viscous, clear liquid with a slightly sweet odor and is widely used in pharmaceutical, cosmetic, personal care, and nutraceutical applications. D-Panthenol is the alcohol analog of pantothenic acid (Vitamin B5) and is converted into Vitamin B5 in the skin and body, where it plays a vital role in cellular metabolism and tissue repair. Its moisturizing, anti-inflammatory, and healing properties make it highly valuable across industries.

Description

D-Panthenol USP

Primary Uses 

Cosmetics & Personal Care

  • Used in skin care products (lotions, creams, serums) for its moisturizing, soothing, and anti-inflammatory properties. 
  • Improves skin hydration, reduces redness, and enhances skin barrier repair. 
  • Commonly found in shampoos, conditioners, and hair serums to improve hair strength, shine, and manageability. 
  • A key ingredient in baby care products due to its mildness and skin-healing benefits. 
  • Included in after-sun and burn relief products for its calming effects. 

Pharmaceuticals

  • Used in wound healing creams, ointments, and gels for its epithelialization-promoting and anti-inflammatory actions. 
  • Incorporated into nasal sprays, eye drops, and oral formulations for mucosal repair. 
  • Applied in burn and dermatitis treatment formulations. 
  • Serves as a humectant and skin protectant in topical drugs. 

Nutraceuticals & Dietary Supplements

  • Used in vitamin formulations and fortified beverages as a source of Vitamin B5. 
  • Supports adrenal function, cellular metabolism, and skin/mucosal health. 

Secondary Uses

Veterinary Care

  • Used in veterinary skin creams and hair products for animals to promote healing and coat health. 
  • Applied in topical ointments for livestock to treat minor wounds and dermatitis. 

Industrial Applications

  • Used in industrial skin-care formulations (e.g., barrier creams for workers). 
  • Added in formulations for protective creams used in occupational settings to treat or prevent irritant contact dermatitis. 

Research & Biotechnology

  • Utilized in cell culture media and tissue engineering applications due to its role in cellular repair and proliferation.
PRODUCT KEY FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide 
  • Common/Trade Name: D-Panthenol USP 
  • CAS Number: 81-13-0 
  • HS Code: 2936.26.00 
  • Molecular Formula: C9H19NO4 
  • Synonyms: 
    • Provitamin B5 
    • Dexpanthenol 
    • Pantothenol 

 

2. Physical & Chemical Properties

  • Physical State: Viscous liquid 
  • Color & Odor: Colorless to slightly yellow; mild, characteristic odor 
  • Melting Point: Not applicable (liquid form) 
  • Boiling Point: ~118–120°C at 0.15 mmHg 
  • Density: 1.145–1.160 g/cm³ at 20°C 
  • Solubility: 
    • Freely soluble in water and alcohol 
    • Insoluble in oils and hydrocarbons 
  • pH (10% solution): 5.0–7.0 
  • Stability: Stable under recommended storage; sensitive to high heat and oxidizing agents 

 

3. Safety & Hazard Attributes

  • Hazard Class (GHS): Not classified as hazardous 
  • NFPA Ratings: 
    • Health: 0 
    • Flammability: 1 
    • Reactivity: 0 
  • Exposure Limits: No established limits; generally considered safe 
  • Toxicity: Non-toxic; well-tolerated on skin and mucosa 
  • Reactivity: Non-reactive; avoid contact with strong oxidizers 

4. Storage & Handling Attributes

  • Storage Conditions: Store in tightly sealed containers at 15–25°C, away from direct sunlight and heat 
  • Container Type: Amber glass or HDPE containers with airtight seals 
  • Shelf Life: Up to 3 years under optimal conditions 
  • Special Handling: Use clean, dry tools; protect from contamination and moisture 

 

5. Regulatory & Compliance Attributes

  • USP/NF Status: Complies with United States Pharmacopeia (USP) standards 
  • FDA Status: GRAS (Generally Recognized as Safe); approved for cosmetic and pharmaceutical use 
  • REACH Status: Registered under EU REACH 
  • Transportation: Not classified as hazardous for transport 
  • Waste Disposal: Dispose in accordance with local regulations; biodegradable and non-toxic 

 

6. Environmental & Health Impact

  • Ecotoxicity: Not toxic to aquatic or terrestrial life 
  • Persistence: Readily biodegradable 
  • Bioaccumulation: Not expected to bioaccumulate 
  • Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic 

Biodegradability: High; environmentally safe for disposal

SAFETY HANDLING PRECAUTIONS
  • Safety Handling Precautions

Personal Protective Equipment (PPE):

  • Nitrile gloves 
  • Protective eyewear 
  • Lab coat or apron 

Handling Measures:

  • Avoid inhalation of vapors or aerosols during processing 
  • Use in a well-ventilated area 
  • Avoid contact with incompatible substances 

Storage Measures:

  • Keep containers sealed and protected from light and air 
  • Store in original packaging or approved chemical storage containers 

Hygiene Practices:

  • Wash hands thoroughly after handling 
  • Avoid contact with eyes and broken skin 
  • Do not eat or drink in processing areas 

 

First Aid Measures

  • Inhalation: Not expected to pose inhalation hazard; move to fresh air if discomfort occurs 
  • Skin Contact: Generally non-irritating; rinse with water if needed 
  • Eye Contact: Rinse with water for several minutes; seek medical attention if irritation persists 
  • Ingestion: Non-toxic in small quantities; seek medical advice if large amounts are ingested 

 

Firefighting Measures

  • Fire Hazards: Slightly combustible 
  • Extinguishing Media: Use dry chemical, CO₂, water spray, or foam 
  • Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus 

Decomposition Products: May release carbon oxides upon combustion