HPMC Vivapharm

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HPMC Vivapharm is a high-quality, pharmaceutical-grade hydroxypropyl methylcellulose polymer widely used as an excipient and functional ingredient. It appears as a fine, white to off-white, odorless powder with excellent solubility in cold water and forms clear, viscous solutions. This cellulose ether derivative offers excellent film-forming, thickening, emulsifying, and controlled-release properties. Vivapharm E50 is prized in pharmaceutical, food, and cosmetic industries for its versatility, stability, and safety profile.

Description

HPMC Vivapharm

Primary Uses 

  1. Pharmaceutical Industry
  • Used as a tablet binder and film former in oral solid dosage forms to improve tablet integrity and controlled drug release.
  • Acts as a matrix former in sustained-release formulations, providing controlled dissolution profiles for active pharmaceutical ingredients.
  • Functions as a disintegrant or swellable excipient to facilitate tablet disintegration where required.
  • Utilized as a suspending agent and viscosity enhancer in liquid oral formulations and ophthalmic preparations.
  • Serves as a protective coating agent for tablets and capsules to mask taste and improve stability.
  1. Food Industry
  • Employed as a thickener, stabilizer, and emulsifier in sauces, dressings, bakery products, and dairy alternatives.
  • Used as a gluten substitute or additive in gluten-free baked goods to improve texture and moisture retention.
  • Enhances mouthfeel and shelf-life in low-fat and reduced-calorie food formulations.
  1. Cosmetics and Personal Care
  • Functions as a thickening agent and film former in lotions, creams, shampoos, and conditioners.
  • Provides stabilization in emulsions and suspensions, preventing ingredient separation.
  • Used in hair gels and styling products for desired viscosity and texture.
  1. Industrial Applications
  • Acts as a rheology modifier in paints, adhesives, and printing inks to control flow properties.
  • Used in construction materials such as tile adhesives and cementitious coatings to improve workability and water retention.

 

Secondary Uses 

  1. Biomedical Research
  • Used as a hydrogel base for drug delivery and tissue engineering studies.
  • Employed in cell culture media as a viscosity modifier.
  1. Agriculture
  • Utilized as a carrier or binder in pesticide formulations to improve adhesion and controlled release.
  1. Packaging
  • Incorporated into biodegradable films and edible coatings for food packaging applications.
KEY ATTRIBUTES
  1. Basic Identification Attributes

  • Chemical Name (IUPAC): Hydroxypropyl methylcellulose
  • Common/Trade Name: HPMC Vivapharm E50
  • CAS Number: 9004-65-3
  • HS Code: 3912.90.00
  • Molecular Formula: C56H108O30 (approximate polymer unit)
  • Synonyms: Hypromellose; Methylhydroxypropyl cellulose; Methocel E50
  1. Physical & Chemical Properties

  • Physical State: Fine powder
  • Color & Odor: White to off-white; odorless
  • Viscosity (2% aqueous solution): ~50 mPa·s at 20°C
  • Solubility: Soluble in cold water, insoluble in hot water and organic solvents
  • pH (1% solution): Neutral to slightly alkaline (6.5–8.5)
  • Thermal Stability: Stable up to ~200°C
  • Film-Forming Ability: Excellent, clear films upon drying
  1. Safety & Hazard Attributes

  • GHS Classification: Non-hazardous; Generally Recognized As Safe (GRAS)
  • Toxicity: Non-toxic and non-irritant at typical use levels
  • Exposure Limits: No specific occupational exposure limits
  1. Storage & Handling Attributes

  • Container Type: Sealed polyethylene bags or drums with moisture barrier
  • Storage Conditions: Store in cool, dry place away from moisture and direct sunlight
  • Shelf Life: Up to 36 months if stored properly
  • Handling Notes: Avoid dust generation; use dust masks in bulk handling
  1. Regulatory & Compliance Attributes

  • Approved for pharmaceutical use by USP, EP, JP
  • Food additive status approved by FDA (E464) and EFSA
  • Complies with REACH and other global chemical regulations
  1. Environmental & Health Impact

  • Biodegradability: Biodegradable under aerobic conditions
  • Ecotoxicity: Low environmental toxicity
  • Bioaccumulation: Not expected to bioaccumulate
  • Carcinogenicity/Mutagenicity: Not classified
SAFETY HANDLING PRECAUTIONS
  1. Safety Handling Precautions
  • PPE Required: Dust mask, gloves, and safety goggles recommended during powder handling
  • Handling Guidelines: Use in well-ventilated areas; avoid dust accumulation
  • Hygiene Practices: Wash hands after handling; avoid inhalation of dust

 

  1. First Aid Measures
  • Inhalation: Move to fresh air if respiratory irritation occurs
  • Skin Contact: Wash with soap and water if irritation develops
  • Eye Contact: Rinse thoroughly with water for 15 minutes; seek medical advice if irritation persists
  • Ingestion: Generally regarded as safe; seek medical advice if excessive ingestion occurs

 

  1. Firefighting Measures
  • Fire Hazards: Non-flammable, but may burn under extreme heat
  • Extinguishing Media: Water spray, foam, dry chemical, or COâ‚‚
  • Special Precautions: Avoid inhalation of smoke from burning material
  • Combustion Products: Carbon oxides and other organic compounds