Rafoxanide BP Vet

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Rafoxanide BP Vet is a halogenated salicylanilide used as a veterinary anthelmintic, specifically effective against liver flukes, gastrointestinal nematodes, and certain ectoparasites in livestock. It works by uncoupling oxidative phosphorylation in parasites, disrupting their energy metabolism and leading to their death. Compliant with the British Pharmacopoeia (BP) for veterinary use, Rafoxanide is widely administered to ruminants like cattle, sheep, and goats. It is commonly formulated in oral drenches, boluses, or feed premixes.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Pharmaceutical Manufacturing, Rafoxanide BP Vet, Rafoxanide Veterinary Grade, Veterinary Dewormer

Description

Table of Contents

Rafoxanide BP Vet

Primary Uses

Veterinary Medicine

Anthelmintic for Ruminants:
Used to treat and control fascioliasis (liver fluke infections) caused by Fasciola hepatica and Fasciola gigantica in cattle, sheep, and goats.
Nematode Control:
Active against haematophagous nematodes such as Haemonchus contortus and Bunostomum spp. in the gastrointestinal tract.
Ectoparasite Treatment:
Shows efficacy against certain external parasites, including Hypoderma larvae and nasal bots (Oestrus ovis) in sheep.
Preventive Use:
Used prophylactically in fluke-prone grazing regions to prevent fluke infestations in livestock during high-risk seasons.

Livestock Management

Enhances overall herd health by eliminating subclinical parasitic burdens that reduce feed efficiency.
Used in strategic deworming programs to maintain parasite control and prevent resistance development when rotated with other classes of anthelmintics.

Secondary Uses

Veterinary Formulation Development

Used as an active ingredient in the development of combination products for broader-spectrum parasitic control (e.g., with levamisole or albendazole).

Parasitology Research

Utilized in veterinary and parasitology studies to assess flukicide efficacy and resistance patterns in livestock parasites.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 3-chloro-4-(4-chlorophenoxy)-5-(trifluoromethyl)-2'-hydroxybenzamide
Common/Trade Name: Rafoxanide BP Vet
CAS Number: 22662-39-1
HS Code: 2933.39.90
Synonyms: Flukiver; Salicylanilide anthelmintic; Rafoxanide

2. Physical & Chemical Properties

Physical State: Solid (powder or crystalline substance)
Color & Odor: Pale yellow to beige; faint odor
Solubility: Practically insoluble in water; soluble in organic solvents (e.g., acetone, chloroform)
Molecular Weight: 461.7 g/mol
Melting Point: ~250°C (decomposes)

3. Safety & Hazard Attributes

GHS Classification: May cause skin and eye irritation; harmful if swallowed
Toxicity: Low toxicity to target species at recommended doses; potential for toxicity in overdose
Exposure Limits: Not established; handle with care using veterinary handling protocols

4. Storage & Handling Attributes

Storage Conditions: Store in a tightly closed container in a cool, dry place away from light and moisture
Container Type: Plastic or fiber drums with polyethylene liners
Shelf Life: Typically 2–3 years under recommended conditions
Handling Precautions: Avoid dust formation; use appropriate PPE during mixing or formulation

5. Regulatory & Compliance Attributes

Complies with British Pharmacopoeia (BP) veterinary standards
Approved for veterinary use in many regions under regulated conditions
Manufactured in GMP-compliant veterinary pharmaceutical facilities

6. Environmental & Health Impact

Biodegradability: Slowly biodegradable; persists in manure and pasture
Ecotoxicity: Toxic to aquatic organisms; avoid contamination of waterways
Bioaccumulation: Potential for accumulation in aquatic environments if misused

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, dust mask, and eye protection
Handling Guidelines: Avoid inhalation of dust; avoid contact with skin and eyes
Storage Measures: Keep containers tightly closed and stored in a dry, well-ventilated area away from incompatible substances

First Aid Measures

Inhalation: Remove to fresh air; seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water; seek medical attention for irritation
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; seek medical help
Ingestion: Rinse mouth; do not induce vomiting; seek immediate veterinary or medical assistance

Firefighting Measures

Fire Hazards: Non-flammable but may decompose at high temperatures releasing toxic gases
Extinguishing Media: Use dry chemical, foam, or CO₂; avoid direct water spray
Special Precautions: Wear protective gear and self-contained breathing apparatus
Hazardous Combustion Products: Hydrogen chloride, carbon oxides, fluorinated compounds