Sulfadiazine Base BP

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Sulfadiazine Base BP is a broad-spectrum sulfonamide antibiotic used primarily in veterinary and human medicine to treat bacterial infections. It functions by inhibiting bacterial synthesis of folic acid, thereby preventing bacterial growth and proliferation. The British Pharmacopoeia (BP) grade ensures pharmaceutical-grade purity and quality suitable for formulation into tablets, suspensions, and topical preparations.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Antibacterial Agent, Pharmaceutical industry, Sulfadiazine Base, Sulfadiazine BP, Sulfonamide Antibiotic, White to off-white powder

Description

Table of Contents

Sulfadiazine Base BP

Primary Uses

Human Medicine

Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, and meningitis caused by susceptible bacteria.
Topical Antimicrobial: Formulated in creams and ointments for treating burns and wound infections.

Veterinary Medicine

Animal Antibiotic: Used to treat infections in livestock and pets, including respiratory, urinary, and soft tissue infections.
Feed Additive: Sometimes included in medicated feed for prophylactic or therapeutic purposes.

Secondary Uses

Research & Development

Microbiological Studies: Used in lab research to study bacterial resistance and antibiotic mechanisms.
Pharmaceutical Formulation: Employed as a model drug in formulation development and bioavailability studies.

Aquaculture

Fish Medication: Used to control bacterial diseases in aquaculture under veterinary supervision.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide
Common/Trade Name: Sulfadiazine Base BP
CAS Number: 68-35-9
HS Code: 2941.20.00
Synonyms: Sulfadiazine, Sulfadiazine base

2. Physical & Chemical Properties

Physical State: White to off-white crystalline powder
Color & Odor: White; odorless to faint sulfurous odor
Melting Point: 254–258 °C (decomposes)
Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents like ethanol
Density: Approx. 1.65 g/cm³

3. Safety & Hazard Attributes

GHS Classification: May cause allergic reactions; handle with care
Toxicity: Moderate; avoid inhalation and prolonged skin contact
Exposure Limits: No specific occupational exposure limits but good industrial hygiene recommended

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry, well-ventilated place, protected from light and moisture
Container Type: Sealed HDPE or glass containers
Shelf Life: 24 months under proper storage conditions
Handling Precautions: Avoid dust generation; use appropriate PPE including gloves and masks

5. Regulatory & Compliance Attributes

Conforms to British Pharmacopoeia (BP) standards
Manufactured under Good Manufacturing Practices (GMP)
Complies with relevant pharmaceutical regulatory requirements including ICH guidelines

6. Environmental & Health Impact

Biodegradability: Limited data; sulfonamides generally degrade under aerobic conditions
Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, lab coat, and dust mask recommended
Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
Storage Measures: Keep containers tightly closed and away from incompatible substances

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash affected area with soap and water; discontinue use if irritation occurs
Eye Contact: Flush with water for at least 15 minutes; seek medical help if irritation persists
Ingestion: Rinse mouth; seek medical advice immediately

Firefighting Measures

Fire Hazards: Combustible solid
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides