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Sulfadiazine Base BP

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Sulfadiazine Base BP is a broad-spectrum sulfonamide antibiotic used primarily in veterinary and human medicine to treat bacterial infections. It functions by inhibiting bacterial synthesis of folic acid, thereby preventing bacterial growth and proliferation. The British Pharmacopoeia (BP) grade ensures pharmaceutical-grade purity and quality suitable for formulation into tablets, suspensions, and topical preparations.

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Description

Primary Uses
Human Medicine
Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, and meningitis caused by susceptible bacteria.

Topical Antimicrobial: Formulated in creams and ointments for treating burns and wound infections.

Veterinary Medicine
Animal Antibiotic: Used to treat infections in livestock and pets, including respiratory, urinary, and soft tissue infections.

Feed Additive: Sometimes included in medicated feed for prophylactic or therapeutic purposes.

 

Secondary Uses
Research & Development
Microbiological Studies: Used in lab research to study bacterial resistance and antibiotic mechanisms.

Pharmaceutical Formulation: Employed as a model drug in formulation development and bioavailability studies.

Aquaculture
Fish Medication: Used to control bacterial diseases in aquaculture under veterinary supervision.

KEY PRODUCT FEATURES

Basic Identification Attributes
Chemical Name (IUPAC): 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide

Common/Trade Name: Sulfadiazine Base BP

CAS Number: 68-35-9

HS Code: 2941.20.00

Synonyms: Sulfadiazine, Sulfadiazine base

 

Physical & Chemical Properties
Physical State: White to off-white crystalline powder

Color & Odor: White; odorless to faint sulfurous odor

Melting Point: 254–258 °C (decomposes)

Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents like ethanol

Density: Approx. 1.65 g/cm³

 

Safety & Hazard Attributes
GHS Classification: May cause allergic reactions; handle with care

Toxicity: Moderate; avoid inhalation and prolonged skin contact

Exposure Limits: No specific occupational exposure limits but good industrial hygiene recommended

 

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated place, protected from light and moisture

Container Type: Sealed HDPE or glass containers

Shelf Life: 24 months under proper storage conditions

Handling Precautions: Avoid dust generation; use appropriate PPE including gloves and masks

 

Regulatory & Compliance Attributes
Conforms to British Pharmacopoeia (BP) standards

Manufactured under Good Manufacturing Practices (GMP)

Complies with relevant pharmaceutical regulatory requirements including ICH guidelines

 

Environmental & Health Impact
Biodegradability: Limited data; sulfonamides generally degrade under aerobic conditions

Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release

Bioaccumulation: Not significant

 

 

SAFETY HANDLING PRECAUTIONS

PPE Required: Gloves, lab coat, and dust mask recommended

Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact

Storage Measures: Keep containers tightly closed and away from incompatible substances

 

First Aid Measures
Inhalation: Move to fresh air; seek medical attention if symptoms develop

Skin Contact: Wash affected area with soap and water; discontinue use if irritation occurs

Eye Contact: Flush with water for at least 15 minutes; seek medical help if irritation persists

Ingestion: Rinse mouth; seek medical advice immediately

 

Firefighting Measures
Fire Hazards: Combustible solid

Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguishers

Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides

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