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Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Diclofenac Sodium BP
Primary Uses
- Medical & Pharmaceutical Applications
- Pain Relief: Effective in managing acute and chronic pain, including musculoskeletal pain, postoperative pain, and dental pain.
- Anti-inflammatory Treatment: Used in inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout.
- Antipyretic: Reduces fever associated with infections or inflammatory diseases.
- Ophthalmic Use: Formulated in eye drops for postoperative inflammation and ocular pain relief.
- Topical Application: Used in gels, creams, and patches for localized relief of muscle pain, sprains, and strains.
- Injection Form: Employed in hospital settings for rapid relief of severe pain and inflammation.Veterinary Medicine
- Used for analgesia and inflammation control in animals, especially in equine and companion animals for musculoskeletal injuries and post-surgical pain.
Secondary Uses
- Sports Medicine
- Widely used among athletes for rapid treatment of sports injuries such as tendonitis, bursitis, and ligament strains.Dentistry
- Prescribed to reduce pain and inflammation post-dental surgery and procedures like tooth extractions or root canals.Postoperative Care
- Administered to manage pain and inflammation after orthopedic, gynecological, and other surgical procedures.Migraine and Headache Treatment
- Employed as part of acute migraine treatment regimens to alleviate pain and associated symptoms.Combination Formulations
- Often combined with other analgesics, muscle relaxants, or gastroprotective agents for synergistic effects and reduced side effects.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Sodium 2-[(2,6-dichlorophenyl)amino]benzeneacetate
- Common/Trade Name: Diclofenac Sodium
- CAS Number: 15307-86-5
- HS Code: 2933.72.00
- Molecular Formula: C14H10Cl2NNaO2
- Synonyms:
- Diclofenac Sodium BP
- Sodium diclofenac
- 2-(2,6-Dichloroanilino)phenylacetic acid sodium salt
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Solubility: Freely soluble in water and polar solvents
- Melting Point: Approximately 280°C (decomposes)
- Stability: Stable under recommended storage conditions
3. Safety & Hazard Attributes
- Hazard Class (GHS): Harmful if swallowed; may cause gastrointestinal irritation
- Toxicity: Low acute toxicity; contraindicated in certain patients due to risk of cardiovascular and gastrointestinal effects
- Exposure Limits: Use as per pharmaceutical guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from light and moisture
- Container Type: Airtight containers, blister packs, or HDPE bottles
- Shelf Life: Typically 2–3 years if stored properly
5. Regulatory & Compliance Attributes
- Regulatory Status: Approved by major pharmacopeias (BP, USP, EP) for medicinal use
- Transportation: Non-hazardous under normal pharmaceutical transport guidelines
6. Environmental & Health Impact
- Biodegradability: Moderate; environmental persistence under study
- Ecotoxicity: Potential environmental pollutant; disposal should follow regulations
Safety Handling Precautions
- Use appropriate PPE including gloves and masks when handling raw powder.
- Avoid inhalation and direct skin contact.
- Follow pharmaceutical manufacturing GMP guidelines.
First Aid Measures
- Inhalation: Move to fresh air, seek medical attention if symptoms occur.
- Skin Contact: Wash thoroughly with soap and water.
- Eye Contact: Rinse immediately with water for 15 minutes and seek medical care.
- Ingestion: Medical attention required; do not induce vomiting.
Firefighting Measures
- Fire Hazards: Combustible under high temperature
- Extinguishing Media: Water spray, foam, dry chemical powder, CO₂
- Special Precautions: Avoid inhalation of combustion fumes
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