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Mebendazole USP ( Micronized white)
Mebendazole USP (Micronized White) is a pharmaceutical-grade anthelmintic agent used for the treatment of parasitic worm infections. The micronized white powder form offers enhanced bioavailability and better dispersion in pharmaceutical formulations. It is effective against a broad spectrum of intestinal parasites including roundworms, whipworms, hookworms, and pinworms. Mebendazole is commonly used in oral tablet and suspension preparations, ensuring efficient parasite eradication with minimal side effects.
Mebendazole USP ( Micronized white)
Primary Uses
- Anthelmintic Treatment
- Used in pharmaceutical formulations for the treatment of helminthic infections such as ascariasis, trichuriasis, enterobiasis, and hookworm infections.
- Incorporated in oral tablets, chewable tablets, and suspensions for both human and veterinary medicine.
- Pharmaceutical Intermediate
- Utilized in the manufacture of generic and branded anti-parasitic medications.
Secondary Uses
- Research and Development
- Used in biomedical research to study antiparasitic drug mechanisms and efficacy.
- Veterinary Applications
- Occasionally used in veterinary formulations for treating parasitic infections in animals.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Methyl [5-(benzoyl)-1H-benzimidazol-2-yl] carbamate
- Common/Trade Name: Mebendazole USP (Micronized White)
- CAS Number: 31431-39-7
- HS Code: 2933.69.90
- Synonyms: Vermox; Anthelminthic; Mebendazole powder; Benzimidazole carbamate
2. Physical & Chemical Properties
- Physical State: Fine white powder (micronized)
- Color & Odor: White; odorless
- Melting Point: 288 °C (decomposes)
- Solubility: Slightly soluble in water; soluble in dimethylformamide and dimethyl sulfoxide (DMSO)
- Particle Size: Micronized for improved dissolution and bioavailability
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal pharmaceutical handling
- Toxicity: Low acute toxicity; safe when used as directed in formulations
- Exposure Limits: Follow pharmaceutical manufacturing hygiene standards
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from light and moisture
- Container Type: Supplied in airtight, moisture-resistant packaging
- Shelf Life: Typically 2-3 years under recommended storage
- Handling Precautions: Avoid inhalation of powder; use appropriate PPE in manufacturing
5. Regulatory & Compliance Attributes
- Complies with USP (United States Pharmacopeia) standards for pharmaceutical use
- Registered and approved by major drug regulatory authorities for human use
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable; minimal environmental exposure expected
- Ecotoxicity: Low environmental risk when disposed of properly
- Bioaccumulation: Not expected
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic
- PPE Required: Dust mask or respirator, gloves, and protective eyewear during handling
- Handling Guidelines: Work in well-ventilated areas or under local exhaust ventilation
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash with soap and water; consult a physician if irritation occurs
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice promptly if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible under fire conditions; may produce toxic fumes
- Extinguishing Media: Use dry chemical, foam, or carbon dioxide extinguishers
- Special Precautions: Wear full protective gear and self-contained breathing apparatus
- Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and nitrogen oxides
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