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Mebendazole USP ( Micronized white)
Mebendazole USP (Micronized White) is a pharmaceutical-grade anthelmintic agent used for the treatment of parasitic worm infections. The micronized white powder form offers enhanced bioavailability and better dispersion in pharmaceutical formulations. It is effective against a broad spectrum of intestinal parasites including roundworms, whipworms, hookworms, and pinworms. Mebendazole is commonly used in oral tablet and suspension preparations, ensuring efficient parasite eradication with minimal side effects.
Mebendazole USP ( Micronized white)
Primary Uses
- Anthelmintic Treatment
- Used in pharmaceutical formulations for the treatment of helminthic infections such as ascariasis, trichuriasis, enterobiasis, and hookworm infections.
- Incorporated in oral tablets, chewable tablets, and suspensions for both human and veterinary medicine.
- Pharmaceutical Intermediate
- Utilized in the manufacture of generic and branded anti-parasitic medications.
Secondary Uses
- Research and Development
- Used in biomedical research to study antiparasitic drug mechanisms and efficacy.
- Veterinary Applications
- Occasionally used in veterinary formulations for treating parasitic infections in animals.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Methyl [5-(benzoyl)-1H-benzimidazol-2-yl] carbamate
- Common/Trade Name: Mebendazole USP (Micronized White)
- CAS Number: 31431-39-7
- HS Code: 2933.69.90
- Synonyms: Vermox; Anthelminthic; Mebendazole powder; Benzimidazole carbamate
2. Physical & Chemical Properties
- Physical State: Fine white powder (micronized)
- Color & Odor: White; odorless
- Melting Point: 288 °C (decomposes)
- Solubility: Slightly soluble in water; soluble in dimethylformamide and dimethyl sulfoxide (DMSO)
- Particle Size: Micronized for improved dissolution and bioavailability
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal pharmaceutical handling
- Toxicity: Low acute toxicity; safe when used as directed in formulations
- Exposure Limits: Follow pharmaceutical manufacturing hygiene standards
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from light and moisture
- Container Type: Supplied in airtight, moisture-resistant packaging
- Shelf Life: Typically 2-3 years under recommended storage
- Handling Precautions: Avoid inhalation of powder; use appropriate PPE in manufacturing
5. Regulatory & Compliance Attributes
- Complies with USP (United States Pharmacopeia) standards for pharmaceutical use
- Registered and approved by major drug regulatory authorities for human use
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable; minimal environmental exposure expected
- Ecotoxicity: Low environmental risk when disposed of properly
- Bioaccumulation: Not expected
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic
- PPE Required: Dust mask or respirator, gloves, and protective eyewear during handling
- Handling Guidelines: Work in well-ventilated areas or under local exhaust ventilation
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash with soap and water; consult a physician if irritation occurs
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice promptly if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible under fire conditions; may produce toxic fumes
- Extinguishing Media: Use dry chemical, foam, or carbon dioxide extinguishers
- Special Precautions: Wear full protective gear and self-contained breathing apparatus
- Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and nitrogen oxides
Related products
Carbocisteine AJI 92
Carbocisteine AJI 92 is a high-purity pharmaceutical-grade amino acid derivative, chemically known as S-carboxymethyl-L-cysteine. It is a white to off-white crystalline powder with a slightly sulfurous odor and is freely soluble in water. Carbocisteine functions primarily as a mucolytic agent—reducing the viscosity of mucus and promoting expectoration in respiratory tract infections. The "AJI 92" specification refers to its compliance with the purity standards established by Ajinomoto's amino acid quality benchmarks, ensuring it meets stringent pharmaceutical-grade quality control for active pharmaceutical ingredients (APIs). It is widely used in oral syrups, tablets, and granules in both human and veterinary medicine.
Cetirizine Hydrochloride
Cetirizine Hydrochloride is a widely used second-generation antihistamine effective for treating allergic conditions such as allergic rhinitis, chronic urticaria, and other allergy symptoms. It is the hydrochloride salt form of cetirizine, existing as a white to off-white crystalline powder with a slightly bitter taste. Cetirizine HCl acts by selectively blocking peripheral H1 histamine receptors, thereby reducing allergic symptoms without significant sedation or central nervous system depression. It is commonly formulated into tablets, syrups, and capsules as an active pharmaceutical ingredient.
Dicyclomine Hydrochloride
Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.
Diphenhydramine HCL BP
Diphenhydramine HCL BP is a first-generation antihistamine with potent anticholinergic, sedative, and antiemetic properties. It is commonly used to relieve symptoms associated with allergies, hay fever, the common cold, and motion sickness. Diphenhydramine HCL is a white crystalline powder, highly soluble in water, making it suitable for oral, topical, and injectable pharmaceutical formulations. Due to its ability to cross the blood-brain barrier, it causes sedation and is often used as a sleep aid and for managing Parkinson’s disease symptoms.
Gentamycin Sulphate
Gentamycin Sulphate is an aminoglycoside antibiotic derived from Micromonospora purpurea and Micromonospora griseorubida. It appears as a white or off-white crystalline powder, highly soluble in water, with a characteristic aminoglycoside odor. Gentamycin Sulphate is widely used in human and veterinary medicine for its broad-spectrum bactericidal activity against aerobic Gram-negative and some Gram-positive bacteria. It works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, leading to bacterial cell death. Due to its effectiveness against severe infections and multi-drug resistant strains, it is an essential antibiotic in clinical settings.
Lidocaine HCL BP
Lidocaine HCL BP is a white crystalline powder or granules that are highly soluble in water. It is a local anesthetic and antiarrhythmic agent widely used in medical and dental fields. Lidocaine HCL BP acts by blocking nerve signal transmission, providing rapid and effective numbing of targeted areas. It conforms to British Pharmacopoeia (BP) standards, ensuring pharmaceutical-grade purity and consistency. It is commonly formulated into injections, topical gels, creams, and patches for pain relief and arrhythmia treatment.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Norfloxacin
Norfloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic used primarily to treat bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Norfloxacin is effective against various Gram-negative and some Gram-positive bacteria and is commonly used in urinary tract infections, prostatitis, and gastroenteritis.
