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Neomycin Sulphate BP Oral
Neomycin Sulphate BP Oral is an aminoglycoside antibiotic derived from Streptomyces fradiae. It is used primarily for treating infections caused by susceptible aerobic gram-negative and some gram-positive bacteria. The oral form is especially utilized for intestinal antisepsis, to reduce bacterial flora before gastrointestinal surgery, or to treat hepatic encephalopathy by decreasing ammonia-producing bacteria in the gut. It is available in powder or tablet form conforming to British Pharmacopoeia (BP) standards, ensuring high purity and efficacy.
Neomycin Sulphate BP Oral
Primary Uses
- Antibacterial Treatment
- Used to treat localized infections caused by susceptible bacteria in the gastrointestinal tract.
- Administered orally for preoperative bowel sterilization to prevent postoperative infections.
- Hepatic Encephalopathy
- Reduces intestinal bacteria that produce ammonia, helping to manage symptoms of hepatic encephalopathy.
- Intestinal Antisepsis
- Used to suppress or eliminate pathogenic bacteria in the intestines during treatment of bacterial infections or before surgery.
Secondary Uses
- Combination Therapy
- Sometimes used with other antibiotics for treating resistant bacterial infections.
- Topical Use (Off-label)
- Although primarily oral, neomycin sulfate may be part of topical formulations for minor skin infections in certain cases.
- Veterinary Applications
- Occasionally used orally in veterinary medicine for intestinal infections under veterinary guidance.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2S)-4-amino-N-[(1R,2R,3R,4R,6R)-4,6-diamino-3-[[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy]-2-hydroxycyclohexyl]-2-hydroxybutanamide sulfate (1:1)
- Common/Trade Name: Neomycin Sulphate BP Oral
- CAS Number: 1405-10-3
- HS Code: 2941.90.20 (Antibiotics)
2. Physical & Chemical Properties
- Physical State: White or off-white crystalline powder or tablets
- Solubility: Freely soluble in water
- Stability: Stable under normal storage conditions
3. Safety & Hazard Attributes
- GHS Classification: Harmful if swallowed; may cause allergic reactions
- Toxicity: Potential nephrotoxicity and ototoxicity with systemic absorption; avoid prolonged use without medical supervision
- Exposure Limits: Handle with care; avoid ingestion by non-patients
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light and moisture
- Container Type: Sealed pharmaceutical-grade containers or blister packs
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Use gloves and avoid inhalation of powder
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Approved by regulatory authorities for oral antibacterial use
- Prescription-only medicine (POM) status in most jurisdictions
6. Environmental & Health Impact
- Biodegradability: Biodegradable in the environment under normal conditions
- Ecotoxicity: Potentially toxic to aquatic life; avoid environmental release
- Bioaccumulation: Not significant
- Allergenicity: Possible hypersensitivity reactions in some individuals
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended during handling of powder
- Handling Guidelines: Use in well-ventilated areas; avoid contact with skin and eyes
- Storage Measures: Keep containers tightly closed and stored away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
- Skin Contact: Wash thoroughly with soap and water; discontinue use if rash develops
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical advice if irritation persists
- Ingestion: Only to be taken under medical supervision; in case of overdose, seek immediate medical help
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher if involved in a fire
- Special Precautions: Use protective equipment to avoid inhalation of smoke or dust
- Hazardous Combustion Products: May produce toxic gases such as nitrogen oxides
Related products
Chloramphenicol Palmitate Micronised
Chloramphenicol Palmitate Micronised is a micronized, lipophilic ester derivative of chloramphenicol, designed for improved solubility and bioavailability compared to the parent drug. It appears as a fine, white to off-white powder with enhanced surface area due to micronization. This antibiotic is widely used for oral formulations, particularly pediatric suspensions, due to its palatability and controlled release properties. Chloramphenicol Palmitate exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Its ester form offers better stability and reduced bitterness, making it a preferred choice in pharmaceutical preparations.
Clotrimazole BP2000
Clotrimazole BP2000 is a broad-spectrum antifungal agent belonging to the imidazole class. It appears as a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents like ethanol and chloroform. Clotrimazole is widely used in pharmaceutical formulations for the treatment of fungal infections affecting the skin, mucous membranes, and nails. Its mechanism involves inhibition of ergosterol synthesis, a vital component of fungal cell membranes, leading to increased cell permeability and fungal cell death. BP2000 indicates compliance with British Pharmacopoeia standards ensuring high purity and consistent quality suitable for pharmaceutical applications.
Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Dicyclomine Hydrochloride
Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.
Diloxanide Furoate
Diloxanide Furoate is an orally administered antiprotozoal agent used primarily for the treatment of amoebiasis. It is a furan-based derivative that acts as a luminal amoebicide, effectively targeting Entamoeba histolytica cysts and trophozoites within the intestinal lumen. This compound is well-regarded for its efficacy in eradicating asymptomatic cyst carriers and as a follow-up treatment after systemic amoebicidal therapy. Diloxanide Furoate has good oral bioavailability and a favorable safety profile.
Mepyramine Maleate BP
Mepyramine Maleate BP is an antihistamine drug commonly used to relieve allergic symptoms such as hay fever, urticaria, and other allergic reactions. It works by blocking histamine H1 receptors, reducing allergic responses like itching, swelling, and redness. This compound is a white or off-white crystalline powder, soluble in water and alcohol, widely used in pharmaceutical formulations including tablets, creams, and injectables.
Methyl Salicylate BP
Methyl Salicylate BP is a clear, colorless to pale yellow oily liquid with a characteristic strong, sweet, and minty odor. It is an organic ester commonly used for its analgesic, anti-inflammatory, and flavoring properties. Methyl Salicylate is widely used in pharmaceutical preparations, topical pain relief products, cosmetics, and as a fragrance ingredient.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
