Neomycin Sulphate BP Oral Amaris Chemicals
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Neomycin Sulphate BP Oral

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Neomycin Sulphate BP Oral is an aminoglycoside antibiotic derived from Streptomyces fradiae. It is used primarily for treating infections caused by susceptible aerobic gram-negative and some gram-positive bacteria. The oral form is especially utilized for intestinal antisepsis, to reduce bacterial flora before gastrointestinal surgery, or to treat hepatic encephalopathy by decreasing ammonia-producing bacteria in the gut. It is available in powder or tablet form conforming to British Pharmacopoeia (BP) standards, ensuring high purity and efficacy.

 

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Description

Neomycin Sulphate BP Oral

Primary Uses 

  1. Antibacterial Treatment
    • Used to treat localized infections caused by susceptible bacteria in the gastrointestinal tract.
    • Administered orally for preoperative bowel sterilization to prevent postoperative infections.
  2. Hepatic Encephalopathy
    • Reduces intestinal bacteria that produce ammonia, helping to manage symptoms of hepatic encephalopathy.
  3. Intestinal Antisepsis
    • Used to suppress or eliminate pathogenic bacteria in the intestines during treatment of bacterial infections or before surgery.

Secondary Uses 

  1. Combination Therapy
    • Sometimes used with other antibiotics for treating resistant bacterial infections.
  2. Topical Use (Off-label)
    • Although primarily oral, neomycin sulfate may be part of topical formulations for minor skin infections in certain cases.
  3. Veterinary Applications
    • Occasionally used orally in veterinary medicine for intestinal infections under veterinary guidance.

 

KEY PRODUCT FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): (2S)-4-amino-N-[(1R,2R,3R,4R,6R)-4,6-diamino-3-[[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy]-2-hydroxycyclohexyl]-2-hydroxybutanamide sulfate (1:1)
  • Common/Trade Name: Neomycin Sulphate BP Oral
  • CAS Number: 1405-10-3
  • HS Code: 2941.90.20 (Antibiotics)

2. Physical & Chemical Properties

  • Physical State: White or off-white crystalline powder or tablets
  • Solubility: Freely soluble in water
  • Stability: Stable under normal storage conditions

3. Safety & Hazard Attributes

  • GHS Classification: Harmful if swallowed; may cause allergic reactions
  • Toxicity: Potential nephrotoxicity and ototoxicity with systemic absorption; avoid prolonged use without medical supervision
  • Exposure Limits: Handle with care; avoid ingestion by non-patients

4. Storage & Handling Attributes

  • Storage Conditions: Store in a cool, dry place, protected from light and moisture
  • Container Type: Sealed pharmaceutical-grade containers or blister packs
  • Shelf Life: Typically 2–3 years if stored properly
  • Handling Precautions: Use gloves and avoid inhalation of powder

5. Regulatory & Compliance Attributes

  • Complies with British Pharmacopoeia (BP) standards
  • Approved by regulatory authorities for oral antibacterial use
  • Prescription-only medicine (POM) status in most jurisdictions

6. Environmental & Health Impact

  • Biodegradability: Biodegradable in the environment under normal conditions
  • Ecotoxicity: Potentially toxic to aquatic life; avoid environmental release
  • Bioaccumulation: Not significant
  • Allergenicity: Possible hypersensitivity reactions in some individuals
SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

  • PPE Required: Gloves and dust mask recommended during handling of powder
  • Handling Guidelines: Use in well-ventilated areas; avoid contact with skin and eyes
  • Storage Measures: Keep containers tightly closed and stored away from incompatible substances

First Aid Measures

  • Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
  • Skin Contact: Wash thoroughly with soap and water; discontinue use if rash develops
  • Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical advice if irritation persists
  • Ingestion: Only to be taken under medical supervision; in case of overdose, seek immediate medical help

Firefighting Measures

  • Fire Hazards: Non-flammable
  • Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher if involved in a fire
  • Special Precautions: Use protective equipment to avoid inhalation of smoke or dust
  • Hazardous Combustion Products: May produce toxic gases such as nitrogen oxides

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