Hydrocortisone Base BP 93 Micro Amaris Chemicals
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PHARMACEUTICAL GRADE

Hydrocortisone Base BP 93 Micro

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Hydrocortisone Base BP 93 Micro is a highly purified, micronized form of hydrocortisone base compliant with British Pharmacopoeia (BP) standards. It is a white to off-white fine powder designed for enhanced solubility and bioavailability in pharmaceutical formulations. As a corticosteroid hormone analog, it exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic activities. The micronized particle size (~93 microns) facilitates improved dispersion in topical, injectable, and oral dosage forms.

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Description

Hydrocortisone Base BP 93 Micro

Primary Uses 

  1. Pharmaceutical Industry
  • Used as an active ingredient in topical formulations such as creams, ointments, gels, and lotions for the treatment of inflammatory skin conditions including eczema, dermatitis, psoriasis, and allergic reactions.
  • Incorporated in injectable and oral dosage forms for systemic corticosteroid therapy to manage autoimmune diseases, allergic reactions, adrenal insufficiency, and inflammatory disorders.
  • Employed in ophthalmic preparations for eye inflammation and allergic conjunctivitis.
  • Used in compounding pharmacies to prepare customized corticosteroid therapies.
  1. Veterinary Medicine
  • Utilized in veterinary formulations for treating inflammatory and allergic conditions in animals.

Secondary Uses

  1. Cosmetic and Dermatological Research
  • Used in anti-inflammatory cosmetic formulations under strict regulatory controls for sensitive skin treatments.
  • Applied in research to study corticosteroid mechanisms of action and skin barrier modulation.
  1. Combination Drug Formulations
  • Combined with antibiotics, antifungal agents, or local anesthetics to enhance therapeutic efficacy in multi-active topical treatments.
KET PRODUCT FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
  • Common/Trade Name: Hydrocortisone Base BP
  • CAS Number: 50-23-7
  • HS Code: 2937.29.00
  • Molecular Formula: C21H30O5
  • Synonyms: Cortisol; Hydrocortisone; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione

2. Physical & Chemical Properties

  • Physical State: Micronized powder (particle size ~93 microns)
  • Color & Odor: White to off-white; odorless or faint odor
  • Melting Point: 213–216 °C (decomposes)
  • Solubility: Practically insoluble in water; soluble in ethanol, acetone, and chloroform
  • Stability: Stable under recommended storage; sensitive to light and moisture

3. Safety & Hazard Attributes

  • GHS Classification: Not classified as hazardous; may cause irritation on contact
  • Toxicity: Low acute toxicity; systemic effects possible with long-term use
  • Exposure Limits: No specific occupational limits; general good hygiene recommended

4. Storage & Handling Attributes

  • Container Type: Airtight, moisture-proof containers such as glass or HDPE
  • Storage Conditions: Store in a cool, dry, dark environment away from light and moisture
  • Shelf Life: Typically 24 months under proper storage conditions
  • Handling Notes: Avoid dust inhalation; use adequate ventilation

5. Regulatory & Compliance Attributes

  • Compliant with British Pharmacopoeia (BP) standards
  • Approved for pharmaceutical use by major regulatory agencies including FDA and EMA
  • Usage controlled due to corticosteroid potency and side effect profiles

6. Environmental & Health Impact

  • Biodegradability: Moderate, steroid structure slows degradation
  • Ecotoxicity: Potential endocrine disruptor; environmental release should be minimized
  • Bioaccumulation: Not significant
  • Carcinogenicity/Mutagenicity: Not classified
SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

  • PPE Required: Gloves, dust mask, protective eyewear when handling powder
  • Handling Guidelines: Use in well-ventilated areas; avoid inhalation of dust and direct contact
  • Hygiene Practices: Wash hands thoroughly after handling; avoid eating or smoking during use

First Aid Measures

  • Inhalation: Move affected person to fresh air; seek medical advice if symptoms persist
  • Skin Contact: Wash thoroughly with soap and water; get medical attention if irritation occurs
  • Eye Contact: Rinse eyes with plenty of water for 15 minutes; consult physician if irritation continues
  • Ingestion: Rinse mouth; seek emergency medical care for significant ingestion

Firefighting Measures

  • Fire Hazards: Combustible powder; may emit toxic fumes such as carbon oxides on burning
  • Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide (COâ‚‚)
  • Special Precautions: Firefighters should wear protective clothing and self-contained breathing apparatus (SCBA)
  • Decomposition Products: Carbon monoxide, carbon dioxide, and other toxic combustion products

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