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Hydrocortisone Base BP 93 Micro
Hydrocortisone Base BP 93 Micro is a highly purified, micronized form of hydrocortisone base compliant with British Pharmacopoeia (BP) standards. It is a white to off-white fine powder designed for enhanced solubility and bioavailability in pharmaceutical formulations. As a corticosteroid hormone analog, it exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic activities. The micronized particle size (~93 microns) facilitates improved dispersion in topical, injectable, and oral dosage forms.
Hydrocortisone Base BP 93 Micro
Primary Uses
- Pharmaceutical Industry
- Used as an active ingredient in topical formulations such as creams, ointments, gels, and lotions for the treatment of inflammatory skin conditions including eczema, dermatitis, psoriasis, and allergic reactions.
- Incorporated in injectable and oral dosage forms for systemic corticosteroid therapy to manage autoimmune diseases, allergic reactions, adrenal insufficiency, and inflammatory disorders.
- Employed in ophthalmic preparations for eye inflammation and allergic conjunctivitis.
- Used in compounding pharmacies to prepare customized corticosteroid therapies.
- Veterinary Medicine
- Utilized in veterinary formulations for treating inflammatory and allergic conditions in animals.
Secondary Uses
- Cosmetic and Dermatological Research
- Used in anti-inflammatory cosmetic formulations under strict regulatory controls for sensitive skin treatments.
- Applied in research to study corticosteroid mechanisms of action and skin barrier modulation.
- Combination Drug Formulations
- Combined with antibiotics, antifungal agents, or local anesthetics to enhance therapeutic efficacy in multi-active topical treatments.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
- Common/Trade Name: Hydrocortisone Base BP
- CAS Number: 50-23-7
- HS Code: 2937.29.00
- Molecular Formula: C21H30O5
- Synonyms: Cortisol; Hydrocortisone; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
2. Physical & Chemical Properties
- Physical State: Micronized powder (particle size ~93 microns)
- Color & Odor: White to off-white; odorless or faint odor
- Melting Point: 213–216 °C (decomposes)
- Solubility: Practically insoluble in water; soluble in ethanol, acetone, and chloroform
- Stability: Stable under recommended storage; sensitive to light and moisture
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous; may cause irritation on contact
- Toxicity: Low acute toxicity; systemic effects possible with long-term use
- Exposure Limits: No specific occupational limits; general good hygiene recommended
4. Storage & Handling Attributes
- Container Type: Airtight, moisture-proof containers such as glass or HDPE
- Storage Conditions: Store in a cool, dry, dark environment away from light and moisture
- Shelf Life: Typically 24 months under proper storage conditions
- Handling Notes: Avoid dust inhalation; use adequate ventilation
5. Regulatory & Compliance Attributes
- Compliant with British Pharmacopoeia (BP) standards
- Approved for pharmaceutical use by major regulatory agencies including FDA and EMA
- Usage controlled due to corticosteroid potency and side effect profiles
6. Environmental & Health Impact
- Biodegradability: Moderate, steroid structure slows degradation
- Ecotoxicity: Potential endocrine disruptor; environmental release should be minimized
- Bioaccumulation: Not significant
- Carcinogenicity/Mutagenicity: Not classified
Safety Handling Precautions
- PPE Required: Gloves, dust mask, protective eyewear when handling powder
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation of dust and direct contact
- Hygiene Practices: Wash hands thoroughly after handling; avoid eating or smoking during use
First Aid Measures
- Inhalation: Move affected person to fresh air; seek medical advice if symptoms persist
- Skin Contact: Wash thoroughly with soap and water; get medical attention if irritation occurs
- Eye Contact: Rinse eyes with plenty of water for 15 minutes; consult physician if irritation continues
- Ingestion: Rinse mouth; seek emergency medical care for significant ingestion
Firefighting Measures
- Fire Hazards: Combustible powder; may emit toxic fumes such as carbon oxides on burning
- Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide (CO₂)
- Special Precautions: Firefighters should wear protective clothing and self-contained breathing apparatus (SCBA)
- Decomposition Products: Carbon monoxide, carbon dioxide, and other toxic combustion products
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