
Sulphadoxine BP 98
Sulphadoxine BP 98 is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.
Primary Uses
Human Medicine
Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.
Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.
Veterinary Medicine
Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.
Secondary Uses
Research & Development
Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.
Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.
Public Health Programs
Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.
Basic Identification Attributes
Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Common/Trade Name: Sulphadoxine BP 98
CAS Number: 2447-57-6
HS Code: 2941.20.00
Synonyms: Sulfadoxine, Sulphadoxine
Physical & Chemical Properties
Physical State: White crystalline powder
Color & Odor: White; odorless to faint sulfur-like odor
Melting Point: 190–194 °C
Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents
Density: Approx. 1.5 g/cm³
Safety & Hazard Attributes
GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions
Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome
Exposure Limits: No specific occupational limits; handle with care
Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture
Container Type: Sealed HDPE or glass containers
Shelf Life: 24 months under recommended storage conditions
Handling Precautions: Avoid dust generation; use PPE such as gloves and masks
Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards
Manufactured under Good Manufacturing Practices (GMP)
Approved for use in antimalarial combination therapies by relevant regulatory authorities
Environmental & Health Impact
Biodegradability: Limited biodegradability under aerobic conditions
Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
Bioaccumulation: Not significant
PPE Required: Gloves, protective clothing, and dust masks recommended
Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
Storage Measures: Keep containers tightly closed and dry
First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop
Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs
Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists
Ingestion: Rinse mouth and seek medical advice promptly
Firefighting Measures
Fire Hazards: Combustible solid
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
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Miconazole Nitrate BP is a high-purity, pharmaceutical-grade antifungal agent conforming to British Pharmacopoeia (BP) specifications. It is widely used in the formulation of topical and oral pharmaceutical products for the treatment of fungal infections caused by dermatophytes and yeasts, including Candida species. Miconazole Nitrate functions by inhibiting the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to cell death.
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