Sulphadoxine BP 98

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Sulphadoxine BP 98 is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.

Description

Primary Uses
Human Medicine
Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.

Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.

Veterinary Medicine
Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.

 

Secondary Uses
Research & Development
Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.

Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.

Public Health Programs
Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.

PRODUCT KEY FEATURES

Basic Identification Attributes
Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

Common/Trade Name: Sulphadoxine BP 98

CAS Number: 2447-57-6

HS Code: 2941.20.00

Synonyms: Sulfadoxine, Sulphadoxine

 

Physical & Chemical Properties
Physical State: White crystalline powder

Color & Odor: White; odorless to faint sulfur-like odor

Melting Point: 190–194 °C

Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents

Density: Approx. 1.5 g/cm³

 

Safety & Hazard Attributes
GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions

Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome

Exposure Limits: No specific occupational limits; handle with care

 

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture

Container Type: Sealed HDPE or glass containers

Shelf Life: 24 months under recommended storage conditions

Handling Precautions: Avoid dust generation; use PPE such as gloves and masks

 

Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards

Manufactured under Good Manufacturing Practices (GMP)

Approved for use in antimalarial combination therapies by relevant regulatory authorities

 

Environmental & Health Impact
Biodegradability: Limited biodegradability under aerobic conditions

Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

PPE Required: Gloves, protective clothing, and dust masks recommended

Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact

Storage Measures: Keep containers tightly closed and dry

 

First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop

Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs

Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists

Ingestion: Rinse mouth and seek medical advice promptly

 

Firefighting Measures
Fire Hazards: Combustible solid

Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguishers

Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides