Loperamide HCL

Whatsapp Order

Loperamide HCL is a synthetic opioid-receptor agonist used primarily as an antidiarrheal medication. It acts on the µ-opioid receptors in the intestinal wall to decrease gut motility, prolonging transit time and allowing increased absorption of fluids and electrolytes. Loperamide HCL is widely used in pharmaceutical formulations to treat acute and chronic diarrhea, including travelers’ diarrhea and diarrhea associated with inflammatory bowel disease. It is a white to off-white crystalline powder, highly soluble in water and commonly supplied in pharmaceutical grade for oral dosage forms.

Add to compare

Add to wishlist

Category: Active Pharmaceutical Ingredients (APIs) Tags: Anti-Diarrheal API, Loperamide Hydrochloride, Pharmaceutical industry, White crystalline powder

Description

Table of Contents

Loperamide HCL

Primary Uses

Pharmaceutical Industry

Active pharmaceutical ingredient (API) in antidiarrheal medications for humans and veterinary use.
Used in over-the-counter and prescription drug formulations to control symptoms of diarrhea by slowing intestinal motility.
Incorporated into capsules, tablets, and liquid oral suspensions for easy administration.

Veterinary Medicine

Used to manage diarrhea in livestock and pets, improving hydration and nutrient absorption during digestive upset.

Secondary Uses

Research and Development

Utilized in pharmacological research studying opioid receptor activity and gastrointestinal motility.
Used in experimental models for evaluating antidiarrheal compounds and intestinal physiology.

Formulation Studies

Employed in formulation optimization for controlled-release and combination products targeting gastrointestinal disorders.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide hydrochloride
Common/Trade Name: Loperamide HCL
CAS Number: 53179-11-6
HS Code: 2941.90.10
Synonyms: Loperamide hydrochloride; antidiarrheal agent; Imodium HCL (brand-associated)

2. Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; odorless
Solubility: Freely soluble in water and ethanol
Melting Point: 230–236 °C (decomposes)
Molecular Weight: 493.05 g/mol

3. Safety & Hazard Attributes

GHS Classification: Harmful if swallowed; may cause respiratory depression in overdose
Toxicity: Low toxicity at therapeutic doses; risk of CNS effects at high doses
Exposure Limits: Use standard pharmaceutical manufacturing safety protocols

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place protected from light and moisture
Container Type: Sealed, pharmaceutical-grade packaging to maintain purity
Shelf Life: Typically 2–3 years under recommended storage conditions
Handling Precautions: Avoid inhalation and skin contact; use appropriate PPE in manufacturing environments

5. Regulatory & Compliance Attributes

Approved for use by FDA, EMA, and other global pharmaceutical regulatory authorities
Manufactured under Good Manufacturing Practices (GMP) guidelines
Controlled substance regulations may apply depending on jurisdiction

6. Environmental & Health Impact

Biodegradability: Not readily biodegradable; disposal must follow pharmaceutical waste regulations
Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
Bioaccumulation: Not significant
Carcinogenicity/Mutagenicity: Not classified as carcinogenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, lab coat, and dust mask or respirator in powder handling
Handling Guidelines: Handle in well-ventilated areas; minimize dust generation
Storage Measures: Keep container tightly closed; avoid moisture and contamination

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash with soap and water; seek medical advice if irritation occurs
Eye Contact: Rinse immediately with water for 15 minutes; consult physician if irritation persists
Ingestion: Seek immediate medical attention in case of overdose; supportive treatment required

Firefighting Measures

Fire Hazards: Not highly flammable but may decompose on heating producing hazardous fumes
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Special Precautions: Wear full protective equipment and self-contained breathing apparatus if exposed to smoke
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides