Phloretin

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Product Description

Phloretin is a natural dihydrochalcone flavonoid primarily extracted from apple tree leaves and other fruit sources. It is recognized for its potent antioxidant properties and its ability to inhibit melanin synthesis, making it highly valued in cosmetic and pharmaceutical industries. Phloretin is a yellowish crystalline powder with low solubility in water but good solubility in organic solvents. It is widely used in skincare formulations for its skin-brightening, anti-aging, and anti-inflammatory benefits.

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Categories: Analytical Reagents, Antioxidants(cosmetic), COSMETIC AND PERSONAL CARE CHEMICALS, LABORATORY CHEMICALS, Nutraceutical Ingredients (pharmaceutical), PHARMACEUTICAL CHEMICALS Tags: Antioxidant Compound, Natural Flavonoid, Nutraceuticals, Phloretin

Description

Table of Contents

Uses

Primary Uses

Cosmetics and Skincare
- Used as a skin-brightening agent to reduce hyperpigmentation and age spots.
- Acts as an antioxidant protecting skin cells from free radical damage.
- Incorporated in anti-aging formulations to improve skin texture and elasticity.
- Helps inhibit melanin production, making it effective in treating melasma and uneven skin tone.
Pharmaceuticals and Nutraceuticals
- Studied for its anti-inflammatory and potential anticancer properties.
- Used in supplements aimed at reducing oxidative stress.
Research and Development
- Employed in laboratory studies investigating antioxidant mechanisms and skin-related disorders.

Secondary Uses

Food Industry
- Investigated as a natural preservative due to its antioxidant effects (limited use).
Agriculture
- Used experimentally for plant health due to its antifungal properties.

KEY PRODUCT FEATURES

Key Attributes

Basic Identification Attributes

Chemical Name (IUPAC): 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Common/Trade Name: Phloretin
CAS Number: 60-82-2
HS Code: 2934.99.90
Synonyms: Dihydrochalcone, Apple flavonoid

Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: Yellow powder; odorless to slight phenolic scent
Solubility: Poorly soluble in water; soluble in ethanol and DMSO
Melting Point: 218–221°C

Safety & Hazard Attributes

GHS Classification: Not classified as hazardous at typical use levels
Toxicity: Low toxicity; minimal irritation potential
Exposure Limits: No established occupational limits

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place away from light and moisture
Container Type: Sealed glass or plastic containers
Shelf Life: 2 years if stored properly
Handling Precautions: Avoid dust formation and inhalation

Regulatory & Compliance Attributes

Complies with cosmetic ingredient standards
Registered as a natural ingredient in cosmetic and nutraceutical databases

Environmental & Health Impact

Biodegradability: Biodegradable
Ecotoxicity: Low environmental impact
Bioaccumulation: Not expected to bioaccumulate
Safety: Considered safe with standard precautions

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves and dust mask recommended
Handling Guidelines: Use in well-ventilated areas; avoid inhalation of powder
Storage Measures: Keep containers tightly closed and stored in a dry environment

First Aid Measures

Inhalation: Move to fresh air; seek medical advice if irritation occurs
Skin Contact: Wash with soap and water
Eye Contact: Rinse with water for at least 15 minutes; seek medical attention if irritation persists
Ingestion: Rinse mouth; seek medical advice if discomfort occurs