Cross Carmellose Sodium BP

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Cross Carmellose Sodium BP (also known as Croscarmellose Sodium or CCS) is a cross-linked sodium carboxymethyl cellulose polymer. It is a highly efficient, super-disintegrant commonly used in pharmaceutical tablet and capsule formulations. This white to off-white, odorless, and tasteless powder exhibits excellent swelling properties and rapid water uptake, which facilitates fast tablet disintegration and improves drug bioavailability. It is chemically stable, non-toxic, and compatible with a wide range of active pharmaceutical ingredients (APIs).

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Category: Excipients Tags: Crosscarmellose sodium, Nutraceutical and supplement manufacturing, Pharmaceutical tablet and capsule formulations, White to off-white powder

Description

Table of Contents

Cross Carmellose Sodium BP

Primary Uses

Pharmaceuticals

Acts as a superdisintegrant in tablets and capsules to promote rapid break-up and dissolution, enhancing drug absorption.
Used in direct compression and wet granulation tablet formulations for improved mechanical strength and disintegration efficiency.
Utilized in orally disintegrating tablets (ODTs) and fast-dissolving formulations.
Serves as a binder in controlled-release formulations to modify drug release profiles.

Personal Care & Cosmetics

Employed as a thickener and stabilizer in topical gels and creams.
Used to improve texture and moisture retention in skincare products.

Secondary Uses

Food Industry

Occasionally used as a stabilizer or thickening agent in food processing (subject to regulatory approvals).

Industrial Applications

Applied as a thickener, binder, and stabilizer in paints, adhesives, and detergents.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): Cross-linked sodium carboxymethyl cellulose
Common/Trade Name: Cross Carmellose Sodium, Croscarmellose Sodium, CCS
CAS Number: 74811-65-7
HS Code: 3912.90.00
Molecular Formula: Variable (polymeric)
Synonyms:
- Cross-linked sodium CMC
- Sodium carboxymethyl cellulose cross-linked

2. Physical & Chemical Properties

Physical State: White to off-white powder
Color & Odor: Odorless; tasteless
Melting Point: Decomposes before melting
Density: Approximately 0.4–0.6 g/cm³ (bulk density)
Solubility:
- Insoluble in water, but swells rapidly to many times its weight
- Insoluble in organic solvents
pH: Neutral to slightly alkaline in aqueous suspension (~6.5-8.0)
Stability: Chemically stable; resistant to heat and pH variations

3. Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous
NFPA Ratings:
- Health: 0
- Flammability: 1 (combustible dust)
- Reactivity: 0
Exposure Limits: No specific limits; minimize inhalation of dust
Toxicity: Non-toxic; widely used in pharmaceutical applications
Reactivity: Stable; non-reactive under normal conditions

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place away from moisture and direct sunlight
Container Type: Airtight, moisture-proof containers or bags
Shelf Life: Typically 2–3 years if stored properly
Special Handling: Avoid dust formation; use dust masks if needed during handling

5. Regulatory & Compliance Attributes

Pharmacopoeia Standards: Complies with BP, USP, EP specifications
FDA Status: Generally recognized as safe (GRAS) for pharmaceutical use
REACH Status: Registered
Transportation: Not regulated as hazardous
Waste Disposal: Dispose according to local regulations; non-toxic and biodegradable

6. Environmental & Health Impact

Ecotoxicity: Low environmental impact; biodegradable polymer
Persistence: Breaks down naturally in environment
Bioaccumulation: Not expected
Carcinogenicity/Mutagenicity: Not classified as hazardous
Biodegradability: Readily biodegradable

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

Personal Protective Equipment (PPE):

Dust mask or respirator to avoid inhalation
Protective gloves and safety glasses recommended

Handling Measures:

Minimize dust generation
Use proper ventilation when handling powder

Storage Measures:

Keep containers tightly sealed to prevent moisture ingress

Hygiene Practices:

Wash hands after handling
Avoid eating, drinking, or smoking during handling

First Aid Measures

Inhalation: Remove to fresh air; seek medical attention if irritation persists
Skin Contact: Wash with soap and water; unlikely to cause irritation
Eye Contact: Rinse thoroughly with water; seek medical attention if irritation occurs
Ingestion: Non-toxic; rinse mouth and seek medical advice if large amounts ingested