Cetomacrogel 1000BP

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Cetomacrogel 1000BP is a high molecular weight polyethylene glycol (PEG) derivative, typically used as a thickening agent, emulsifier, and stabilizer in pharmaceutical and cosmetic formulations. It appears as a white to off-white, waxy solid or flakes with a neutral odor. Known for its excellent water solubility and compatibility with various ingredients, Cetomacrogel 1000BP enhances texture, viscosity, and stability in creams, ointments, and gels. It serves as a hydrophilic vehicle base in topical and oral pharmaceutical preparations and improves product spreadability and skin feel.

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Categories: Emollients, Excipients, Surfactants(cosmetic) Tags: Cetomacrogol BP, Cosmetic creams and lotions, Non-ionic surfactant, Pharmaceutical emulsions, White to off-white waxy solid

Description

Table of Contents

Cetomacrogel 1000BP

Primary Uses

Pharmaceuticals

Used as a hydrophilic base and thickener in topical ointments, creams, and gels.
Functions as a solubilizer and stabilizer in liquid and semi-solid pharmaceutical formulations.
Acts as a binder and matrix former in oral and topical drug delivery systems.
Employed in suppository bases due to its water-soluble and melting properties.

Cosmetics & Personal Care

Used in moisturizing creams, lotions, and gels to enhance viscosity and texture.
Acts as an emulsifier and stabilizer in oil-in-water emulsions.
Provides a smooth, non-greasy skin feel and improves product spreadability.

Secondary Uses

Industrial Applications

Utilized in lubricant formulations to improve consistency and performance.
Applied in textile and paper industries as a thickening and binding agent.

Food Industry

Occasionally used as a processing aid or carrier for flavor and colorants under regulatory approvals.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): Polyethylene glycol (PEG) with average molecular weight ~1000 Da
Common/Trade Name: Cetomacrogel 1000BP
CAS Number: 25322-68-3 (for PEG 1000)
HS Code: 3907.99.00
Molecular Formula: (C2H4O)nH2O, where n corresponds to molecular weight approx. 1000 Da
Synonyms:
- PEG 1000
- Polyethylene glycol 1000
- Macrogol 1000

Physical & Chemical Properties

Physical State: White to off-white solid flakes or waxy granules
Color & Odor: White to pale; odorless or faintly characteristic odor
Melting Point: 37–40°C (softens and melts)
Boiling Point: Not applicable (decomposes on heating)
Density: ~1.13 g/cm³ at 20°C
Solubility:
- Completely soluble in water
- Soluble in alcohols and glycols
- Insoluble in hydrocarbons and oils
Stability: Stable under normal storage conditions; hygroscopic

Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous
NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
Exposure Limits: No established limits; generally considered safe
Toxicity: Low toxicity; widely used in pharmaceuticals and cosmetics safely
Irritation Potential: Non-irritating to skin and eyes under normal use

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place, tightly closed to prevent moisture uptake
Container Type: Supplied in sealed bags, drums, or pails
Shelf Life: Typically 3 years if stored properly
Special Handling: Avoid dust generation; use PPE as needed

Regulatory & Compliance Attributes

Pharmacopoeial Status: Complies with BP (British Pharmacopoeia) standards
Cosmetic Regulatory Status: Approved for use in cosmetic formulations globally
REACH Status: Registered
Transportation: Not regulated as hazardous material
Waste Disposal: Dispose according to local regulations; biodegradable

Environmental & Health Impact

Ecotoxicity: Low; biodegradable and environmentally friendly
Persistence: Readily biodegradable in the environment
Bioaccumulation: Not expected to bioaccumulate
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

Biodegradability: Readily biodegradable

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE: Use gloves and dust mask if handling large quantities or powders
Handling: Avoid inhalation of dust; ensure adequate ventilation
Storage: Keep container sealed and protected from moisture
Hygiene: Wash hands after handling; do not eat or drink in handling area

First Aid Measures

Inhalation: Move to fresh air if dust inhaled; seek medical attention if symptoms persist
Skin Contact: Wash skin with water; no expected adverse effects
Eye Contact: Rinse with plenty of water; seek medical attention if irritation occurs
Ingestion: Non-toxic; rinse mouth and seek medical advice if large amounts ingested