Dicyclomine Hydrochloride

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Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Dicyclomine Hydrochloride, Drug manufacturing, Hospital supplies, Pharmaceutical ingredient, Smooth muscle relaxant

Description

Table of Contents

Dicyclomine Hydrochloride

Primary Uses

Gastrointestinal Disorders

Irritable Bowel Syndrome (IBS): Relieves abdominal cramping and pain by relaxing the smooth muscles of the gut.
Functional Bowel Disorders: Treats spasms in conditions like spastic colon and diverticulitis.
Gastrointestinal Spasms: Manages spasms associated with colitis, enteritis, and other inflammatory bowel diseases.Preoperative Medication

Used to reduce secretions and relax smooth muscles before surgery or diagnostic procedures involving the gastrointestinal tract.Treatment of Colic

Relieves intestinal colic and discomfort in adults and sometimes pediatric patients.

Secondary Uses

Urinary Bladder Disorders

Sometimes used off-label to relieve bladder spasms in urinary tract dysfunctions.Adjunct Therapy in Gastrointestinal Procedures

Administered to ease discomfort during endoscopy or radiological imaging by reducing bowel motility.Research Applications

Utilized in pharmacological studies focusing on muscarinic receptor antagonists and smooth muscle physiology.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride
Common/Trade Name: Dicyclomine Hydrochloride, Dicycloverine
CAS Number: 67-92-5
HS Code: 2924.99.90
Molecular Formula: C19H35NO2·HCl
Synonyms:
- Dicycloverine Hydrochloride
- Dicyclomine HCl
- Bentyl (brand name)

Physical & Chemical Properties

Physical State: White crystalline powder
Solubility: Soluble in water and alcohol
Melting Point: 164–167°C
Stability: Stable under normal storage conditions

Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous; handle as pharmaceutical chemical
Toxicity: Low acute toxicity, but overdose can cause anticholinergic symptoms
Exposure Limits: Follow pharmaceutical handling guidelines

Storage & Handling

Store in a cool, dry, well-ventilated area away from light
Shelf Life: Typically 2–3 years under proper conditions

Regulatory & Compliance

Approved by FDA and other global regulatory bodies for pharmaceutical use
Included in various pharmacopeias (BP, USP)

Environmental & Health Impact

Low environmental persistence

Not considered ecotoxic or bioaccumulative

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required:

Gloves (nitrile or latex)
Safety goggles
Lab coat or protective apron

Handling Guidelines:

Avoid inhalation of powder and dust
Avoid skin and eye contact
Use in a well-ventilated area or under fume hood
Follow GMP and pharmaceutical manufacturing practices

Storage Measures:

Keep container tightly closed
Store away from moisture and direct sunlight
Store in a cool, dry place

Hygiene Practices:

Wash hands thoroughly after handling
Do not eat, drink, or smoke while handling product
Avoid cross-contamination with other chemicals

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms persist
Skin Contact: Wash with soap and water; consult physician if irritation occurs
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; seek medical advice
Ingestion: Rinse mouth with water; seek medical attention if large amounts ingested