Dimethyl Acetimide

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Dimethyl Acetimide is a versatile organic compound used predominantly as a solvent and intermediate in chemical syntheses. It is a colorless to pale yellow liquid with good solvency properties for a wide range of organic substances. Known for its stability and relatively low toxicity compared to similar amides, Dimethyl Acetimide finds applications in pharmaceuticals, agrochemicals, and specialty chemical manufacturing. Its miscibility with water and many organic solvents makes it suitable for formulation and processing roles.

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Categories: Solvents(pharmaceutical), Solvents(lab) Tags: Clear liquid chemical, Dimethylacetamide, DMAc, Polar aprotic solvent, Polymer & resin production

Description

Table of Contents

Dimethyl Acetimide

Primary Uses

Pharmaceutical Industry

Used as a reaction medium and solvent in the synthesis of active pharmaceutical ingredients (APIs).
Facilitates dissolution and extraction of various drug intermediates due to its polarity and solvent characteristics.
Acts as a stabilizer and carrier solvent in formulations requiring moderate polarity and low volatility.Chemical Synthesis

Serves as an intermediate in the production of dyes, pigments, and other specialty chemicals.
Used as a solvent for polymerization processes and as a reagent in organic synthesis.
Applied in acetylation reactions and as a catalyst medium in certain chemical transformations.Agrochemical Formulations

Used as a solvent and carrier in the production and formulation of herbicides, insecticides, and fungicides.
Improves the solubility and bioavailability of active ingredients in crop protection products.

Secondary Uses

Industrial Cleaning

Utilized in specialized cleaning agents and degreasers for industrial equipment due to its solvent properties.Coatings & Paints

Acts as a solvent and coalescing agent in coatings, paints, and varnishes to enhance drying and film formation.Laboratory Reagent

Employed as a solvent and reagent in analytical chemistry and research laboratories.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): N,N-Dimethylacetamide
Common/Trade Name: Dimethyl Acetimide (often used interchangeably with N,N-Dimethylacetamide or DMAc)
CAS Number: 127-19-5
HS Code: 2924.19.90
Molecular Formula: C4H9NO
Synonyms:
- DMAc
- N,N-Dimethylacetamide
- Acetyl dimethylamide
- Dimethylacetamid

2. Physical & Chemical Properties

Physical State: Clear, colorless to pale yellow liquid
Odor: Mild, amide-like odor
Boiling Point: 164–166°C
Melting Point: −20°C
Density: ~0.937 g/cm³ at 20°C
Solubility: Miscible with water, alcohols, ethers, and many organic solvents
Stability: Stable under normal conditions; hygroscopic

3. Safety & Hazard Attributes

Hazard Class (GHS): Classified as hazardous; skin irritant and suspected reproductive toxin (Category 2)
Toxicity: Moderate toxicity; potential for skin and respiratory irritation
Exposure Limits: Occupational exposure limit typically around 10 ppm (ACGIH TLV)

4. Storage & Handling Attributes

Storage Conditions: Store in tightly sealed containers, in a cool, dry, well-ventilated area away from sources of ignition
Container Type: Glass or steel drums, HDPE containers for smaller volumes
Shelf Life: 1–2 years under proper storage
Handling Precautions: Avoid inhalation, skin and eye contact; use appropriate PPE

5. Regulatory & Compliance Attributes

Listed on REACH, TSCA, and other global chemical inventories
Controlled under chemical safety regulations due to potential reproductive toxicity
Not approved as a food additive or pharmaceutical excipient

6. Environmental & Health Impact

Ecotoxicity: Harmful to aquatic life with long-lasting effects
Persistence: Moderate environmental persistence
Bioaccumulation: Low potential for bioaccumulation
Carcinogenicity/Mutagenicity: Not classified as carcinogenic; suspected reproductive toxin

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required:

Chemical-resistant gloves (e.g., nitrile)
Safety goggles or face shield
Protective lab coat or apron
Use respiratory protection if ventilation is inadequate

Handling Guidelines:

Avoid inhalation of vapors and contact with skin and eyes
Use in well-ventilated areas or fume hoods
Prevent spills and minimize dust or mist formation

Storage Measures:

Keep container tightly closed
Store away from heat, flames, and incompatible materials such as strong oxidizers and acids
Ensure secondary containment to prevent environmental release

Hygiene Practices:

Wash hands thoroughly after handling
Do not eat, drink, or smoke during use
Remove contaminated clothing immediately

First Aid Measures

Inhalation: Move to fresh air immediately; seek medical attention if symptoms such as dizziness or breathing difficulty occur
Skin Contact: Wash affected area with soap and water; seek medical advice if irritation persists
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; consult a physician if irritation occurs
Ingestion: Do not induce vomiting; rinse mouth and seek immediate medical attention

Firefighting Measures

Fire Hazards: Combustible liquid; emits toxic fumes under fire conditions
Extinguishing Media: Use foam, dry chemical, CO₂, or water spray to extinguish fire
Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus (SCBA)
Decomposition Products: Carbon monoxide, nitrogen oxides, and other toxic fumes