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Microcrystalline Cellulose
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Microcrystalline Cellulose (MCC) is a purified, partially depolymerized cellulose prepared by treating alpha-cellulose with mineral acids. It appears as a white, odorless, crystalline powder widely used as a binder, filler, and disintegrant in pharmaceutical tablets and capsules. MCC exhibits excellent compressibility and flow properties, making it ideal for direct compression tableting.
Description
Microcrystalline Cellulose
Primary Uses
- Pharmaceutical Industry
- Tablet binder in direct compression formulations
- Filler/diluent in capsules and tablets
- Disintegrant to promote tablet breakup
- Adsorbent for liquid formulations
- Food Industry
- Anti-caking agent in powdered foods
- Stabilizer in ice creams and frozen desserts
- Fat replacer in low-calorie foods
- Cosmetics & Personal Care
- Bulking agent in pressed powders
- Texture modifier in creams and lotions
Secondary Uses
- Industrial Applications
- Reinforcing agent in composites
- Filter aid in chromatography
- Research & Development
- Model excipient for formulation studies
PRODUCT KEY FEATURES
Basic Identification Attributes
- Chemical Name: Microcrystalline Cellulose
- CAS Number: 9004-34-6
- INCI Name: Cellulose
- HS Code: 3912.31.00
- Synonyms: MCC, Cellulose gel
Physical & Chemical Properties
- Physical State: Fine white powder
- Color: White
- Odor: Odorless
- Solubility:
- Insoluble in water
- Swells in aqueous solutions
- Bulk Density: 0.25-0.45 g/cm³
- Moisture Content: ≤5%
Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous
- Toxicity: Non-toxic
- Exposure Limits: No specific limits
Storage & Handling Attributes
- Storage Conditions:
- Store in tightly closed containers
- Keep in cool, dry place
- Container Type: Multi-wall paper bags or fiber drums
- Shelf Life: 36 months
- Handling Precautions:
- Avoid dust formation
Regulatory & Compliance Attributes
- Complies with:
- USP/NF
- EP
- JP
- FDA 21 CFR 182.1
Environmental & Health Impact
- Biodegradability: Fully biodegradable
- Ecotoxicity: None
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
- PPE Required:
- Dust mask
- Safety glasses
- Handling Guidelines:
- Use local exhaust ventilation
First Aid Measures
- Inhalation: Move to fresh air
- Eye Contact: Rinse with water
- Skin Contact: Wash with soap and water
- Ingestion: Drink plenty of water
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Water spray, foam, CO₂
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