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Prednisolone Base

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Prednisolone Base is a synthetic glucocorticoid steroid widely used for its potent anti-inflammatory and immunosuppressive properties. It is the active form of prednisolone, commonly administered in various pharmaceutical formulations including tablets, injectables, and topical creams. This compound helps manage conditions involving inflammation, allergic reactions, and immune system disorders by modulating the body’s response to these processes.

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Description

 

Primary Uses
Pharmaceuticals
Used in the treatment of inflammatory and autoimmune diseases such as arthritis, lupus, and asthma.

Administered to suppress immune responses in conditions like organ transplant rejection.

Employed in topical formulations to treat skin conditions such as eczema, psoriasis, and dermatitis.

Used in ophthalmic preparations for inflammatory eye conditions.

Veterinary Medicine
Used to manage inflammatory and autoimmune conditions in animals.

 

Secondary Uses
Research and Development
Utilized in clinical and pharmacological research studies investigating steroid effects and inflammatory pathways.

Endocrinology
Used in diagnostic testing of adrenal gland function.

PRODUCT KEY FEATURES

Basic Identification Attributes
Chemical Name (IUPAC): 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione

Common/Trade Name: Prednisolone Base

CAS Number: 50-24-8

HS Code: 2937.29

Synonyms: 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione; Delta-cortef

Physical & Chemical Properties
Physical State: Crystalline powder

Color & Odor: White to off-white; odorless

Solubility: Slightly soluble in water; soluble in alcohol, acetone, and chloroform

Melting Point: Approximately 240–245°C

Stability: Stable under recommended storage conditions

Safety & Hazard Attributes
GHS Classification: May cause skin and eye irritation; harmful if swallowed in large quantities

Toxicity: Moderate; requires careful dosing and medical supervision

Exposure Limits: Follow occupational safety guidelines

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry place protected from light

Container Type: Sealed amber bottles or vials

Shelf Life: Typically 2–3 years

Handling Precautions: Use gloves and protective clothing; avoid inhalation and skin contact

 

Regulatory & Compliance Attributes
Complies with pharmacopeial standards such as USP, BP, and EP

Approved for use in prescription medications worldwide

 

Environmental & Health Impact
Biodegradability: Organic compound; biodegradable under environmental conditions

Ecotoxicity: Low when properly disposed

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions
PPE Required: Gloves, goggles, and lab coat recommended

Handling Guidelines: Avoid inhalation, ingestion, and skin contact; work in well-ventilated areas

Storage Measures: Keep containers tightly closed and protected from light

 

First Aid Measures
Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur

Skin Contact: Wash with soap and water; seek medical advice if irritation develops

Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical attention if irritation persists

Ingestion: Rinse mouth; seek immediate medical attention

 

Firefighting Measures
Fire Hazards: Combustible under fire conditions

Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚

Special Precautions: Wear self-contained breathing apparatus

Hazardous Combustion Products: Carbon oxides and other toxic fumes

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