PVP K 90 USP

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PVP K 90 USP (Polyvinylpyrrolidone K-90) is a high molecular weight water-soluble polymer widely used in pharmaceutical, cosmetic, and industrial applications. Known for its excellent film-forming, adhesive, and thickening properties, PVP K 90 is particularly valued where higher viscosity and stronger binding are required. This grade meets USP standards, ensuring purity and suitability for pharmaceutical use, especially in sustained-release formulations, suspensions, and topical products.

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Category: Excipients Tags: Cosmetics & Personal Care, Pharmaceutical Binder & Excipient, Polyvinylpyrrolidone K-90, PVP K90 USP

Description

Table of Contents

PVP K 90 USP

Primary Uses

Pharmaceutical Industry

Used as a binder in tablets and granules, providing enhanced mechanical strength due to its high molecular weight.
Functions as a suspending and viscosity-increasing agent in liquid formulations and injectables.
Employed in controlled-release formulations to regulate drug release kinetics.
Acts as a film former for protective coatings on tablets and topical products.

Cosmetics and Personal Care

Utilized as a thickener, stabilizer, and film former in creams, lotions, shampoos, and hair styling products.
Enhances moisture retention and skin feel in various skincare formulations.

Industrial Applications

Used as a dispersant and stabilizer in adhesives, inks, and paints.
Applied in the formulation of photographic chemicals and other specialty products.

Secondary Uses

Food Industry

Occasionally used as a stabilizer and emulsifier under regulatory approval.

Laboratory Uses

Serves as a matrix component in biochemical and molecular biology research.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): Poly(1-vinyl-2-pyrrolidone)
Common/Trade Name: PVP K 90 USP
CAS Number: 9003-39-8
HS Code: 3906.90.10
Synonyms: Polyvinylpyrrolidone K-90; Povidone K90

2. Physical & Chemical Properties

Physical State: Fine white to off-white powder
Solubility: Soluble in water and some polar solvents
Molecular Weight: Approximately 360,000 Da (K value 90)
pH (1% solution): 4.0 – 7.0
Odor & Color: Odorless or slight characteristic odor; white powder

3. Safety & Hazard Attributes

GHS Classification: Not classified as hazardous
Toxicity: Low toxicity; generally non-irritant
Exposure Limits: Follow occupational safety guidelines for dust

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry, well-ventilated area, away from moisture and incompatible substances
Container Type: Sealed bags or drums
Shelf Life: 2–3 years if stored properly
Handling Precautions: Avoid dust formation; use appropriate respiratory protection

5. Regulatory & Compliance Attributes

Complies with USP monograph for Polyvinylpyrrolidone
Generally Recognized As Safe (GRAS) for specified uses
Manufactured under GMP conditions

6. Environmental & Health Impact

Biodegradability: Readily biodegradable
Ecotoxicity: Low aquatic toxicity
Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Dust mask, gloves, and eye protection recommended
Handling Guidelines: Use in well-ventilated areas; minimize dust exposure
Storage Measures: Keep containers tightly sealed and stored in a dry environment away from moisture

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if irritation occurs
Skin Contact: Wash with soap and water; seek medical advice if irritation develops
Eye Contact: Rinse eyes with plenty of water for 15 minutes; seek medical attention if needed
Ingestion: Rinse mouth; consult a physician if large quantities ingested

Firefighting Measures

Fire Hazards: Combustible dust may cause explosive atmospheres
Extinguishing Media: Water spray, foam, dry chemical, CO₂
Special Precautions: Avoid dust accumulation; use respiratory and protective clothing
Hazardous Combustion Products: Carbon oxides, nitrogen oxides