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Neomycin Sulphate BP Oral
Neomycin Sulphate BP Oral is an aminoglycoside antibiotic derived from Streptomyces fradiae. It is used primarily for treating infections caused by susceptible aerobic gram-negative and some gram-positive bacteria. The oral form is especially utilized for intestinal antisepsis, to reduce bacterial flora before gastrointestinal surgery, or to treat hepatic encephalopathy by decreasing ammonia-producing bacteria in the gut. It is available in powder or tablet form conforming to British Pharmacopoeia (BP) standards, ensuring high purity and efficacy.
Neomycin Sulphate BP Oral
Primary Uses
- Antibacterial Treatment
- Used to treat localized infections caused by susceptible bacteria in the gastrointestinal tract.
- Administered orally for preoperative bowel sterilization to prevent postoperative infections.
- Hepatic Encephalopathy
- Reduces intestinal bacteria that produce ammonia, helping to manage symptoms of hepatic encephalopathy.
- Intestinal Antisepsis
- Used to suppress or eliminate pathogenic bacteria in the intestines during treatment of bacterial infections or before surgery.
Secondary Uses
- Combination Therapy
- Sometimes used with other antibiotics for treating resistant bacterial infections.
- Topical Use (Off-label)
- Although primarily oral, neomycin sulfate may be part of topical formulations for minor skin infections in certain cases.
- Veterinary Applications
- Occasionally used orally in veterinary medicine for intestinal infections under veterinary guidance.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2S)-4-amino-N-[(1R,2R,3R,4R,6R)-4,6-diamino-3-[[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy]-2-hydroxycyclohexyl]-2-hydroxybutanamide sulfate (1:1)
- Common/Trade Name: Neomycin Sulphate BP Oral
- CAS Number: 1405-10-3
- HS Code: 2941.90.20 (Antibiotics)
2. Physical & Chemical Properties
- Physical State: White or off-white crystalline powder or tablets
- Solubility: Freely soluble in water
- Stability: Stable under normal storage conditions
3. Safety & Hazard Attributes
- GHS Classification: Harmful if swallowed; may cause allergic reactions
- Toxicity: Potential nephrotoxicity and ototoxicity with systemic absorption; avoid prolonged use without medical supervision
- Exposure Limits: Handle with care; avoid ingestion by non-patients
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light and moisture
- Container Type: Sealed pharmaceutical-grade containers or blister packs
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Use gloves and avoid inhalation of powder
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Approved by regulatory authorities for oral antibacterial use
- Prescription-only medicine (POM) status in most jurisdictions
6. Environmental & Health Impact
- Biodegradability: Biodegradable in the environment under normal conditions
- Ecotoxicity: Potentially toxic to aquatic life; avoid environmental release
- Bioaccumulation: Not significant
- Allergenicity: Possible hypersensitivity reactions in some individuals
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended during handling of powder
- Handling Guidelines: Use in well-ventilated areas; avoid contact with skin and eyes
- Storage Measures: Keep containers tightly closed and stored away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
- Skin Contact: Wash thoroughly with soap and water; discontinue use if rash develops
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; seek medical advice if irritation persists
- Ingestion: Only to be taken under medical supervision; in case of overdose, seek immediate medical help
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher if involved in a fire
- Special Precautions: Use protective equipment to avoid inhalation of smoke or dust
- Hazardous Combustion Products: May produce toxic gases such as nitrogen oxides
Related products
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Chloramphenicol Palmitate Micronised
Chloramphenicol Palmitate Micronised is a micronized, lipophilic ester derivative of chloramphenicol, designed for improved solubility and bioavailability compared to the parent drug. It appears as a fine, white to off-white powder with enhanced surface area due to micronization. This antibiotic is widely used for oral formulations, particularly pediatric suspensions, due to its palatability and controlled release properties. Chloramphenicol Palmitate exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Its ester form offers better stability and reduced bitterness, making it a preferred choice in pharmaceutical preparations.
Chlorpheniramine Maleate
Chlorpheniramine Maleate is a first-generation alkylamine antihistamine used primarily to relieve allergy symptoms by blocking H1 histamine receptors. It appears as a white or off-white crystalline powder, freely soluble in water and alcohol. Known for rapid onset and moderate duration of action, it’s widely formulated in pharmaceuticals. It also exhibits mild anticholinergic and sedative effects.
Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Diphenhydramine HCL BP
Diphenhydramine HCL BP is a first-generation antihistamine with potent anticholinergic, sedative, and antiemetic properties. It is commonly used to relieve symptoms associated with allergies, hay fever, the common cold, and motion sickness. Diphenhydramine HCL is a white crystalline powder, highly soluble in water, making it suitable for oral, topical, and injectable pharmaceutical formulations. Due to its ability to cross the blood-brain barrier, it causes sedation and is often used as a sleep aid and for managing Parkinson’s disease symptoms.
Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Piperazine Citrate BP
Piperazine Citrate BP is a pharmaceutical-grade anthelmintic compound used primarily for the treatment of intestinal worm infections, especially ascariasis (roundworms) and enterobiasis (pinworms). It works by paralyzing the worms, allowing them to be expelled naturally from the body through bowel movements. Piperazine Citrate is included in the British Pharmacopoeia (BP) and is known for its safety, efficacy, and wide use in both human and veterinary medicine.
