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Aminosidine Sulphate
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Aminosidine Sulphate USP, also known as Paromomycin Sulphate, is an aminoglycoside antibiotic primarily used to treat parasitic infections and certain bacterial infections. It is a white or off-white crystalline powder, highly soluble in water, and typically administered orally or topically. It works by inhibiting protein synthesis in susceptible microorganisms, thereby exerting a bactericidal and antiparasitic effect. Aminosidine Sulphate is commonly employed in treating intestinal amoebiasis, leishmaniasis, and infections caused by gram-negative bacteria. Its inclusion in the United States Pharmacopeia (USP) signifies compliance with strict quality and purity standards for pharmaceutical use.
Description
Primary UsesÂ
Pharmaceutical & Medical Applications
- Used as an oral antibiotic for treating intestinal parasitic infections such as amoebiasis and giardiasis.
- Administered in the treatment of visceral and cutaneous leishmaniasis, especially in endemic regions.
- Utilized to treat certain bacterial infections caused by gram-negative bacteria, including those resistant to other antibiotics.
- Used topically in some formulations to treat bacterial infections of the skin and mucous membranes.
Veterinary Medicine
- Used to treat parasitic infections in animals, particularly protozoal infections affecting the gastrointestinal tract.
Secondary Uses
Research & Laboratory Use
- Employed in microbiological and pharmacological studies related to aminoglycoside antibiotics.
- Occasionally used as a model drug in drug delivery and resistance mechanism research.
Formulations & Compounded Medications
- Incorporated into combination therapies with other antibiotics or antiparasitic agents for enhanced efficacy.
Sometimes used in veterinary topical ointments or sprays for local infections.
PRODUCT KEY ATTRIBUTES
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2R,3R,4R,5S,6R)-5-Amino-6-[(1R,2R,3R,4R,5S)-4,5-diamino-2-hydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol sulfate
- Common/Trade Names: Aminosidine Sulphate, Paromomycin Sulphate
- CAS Number: 1263-89-4
- HS Code: 2941.90.90
- Molecular Formula: C23H46N4O14·H2SO4
- Synonyms: Paromomycin Sulphate, Aminosidine Sulfate USP
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White, odorless or faint odor
- Melting Point: >230°C (decomposes)
- Boiling Point: N/A (decomposes)
- Density: ~1.6 g/cm³
- Solubility: Highly soluble in water; practically insoluble in ethanol and organic solvents
- pH Level: Slightly acidic to neutral in aqueous solution (~4.5–7)
- Vapor Pressure: Negligible
- Flash Point: Not applicable
- Autoignition Temperature: N/A
3. Safety & Hazard Attributes
- Hazard Class (GHS): Harmful if swallowed; may cause allergic skin reactions
- NFPA Ratings: Health 2, Flammability 0, Reactivity 0
- Exposure Limits: No established OSHA PEL; handle as pharmaceutical chemical
- Reactivity: Stable under normal conditions
- Incompatibilities: Strong oxidizers, acids, and bases
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place below 25°C, protected from moisture and light
- Container Type: Sealed amber glass or plastic containers
- Shelf Life: Typically 2-3 years under proper storage
- Special Handling: Avoid inhalation, skin, and eye contact; use protective gloves and eyewear
5. Regulatory & Compliance Attributes
- Regulatory Status: Listed in USP, approved for pharmaceutical use in many countries
- Transportation: Not classified as hazardous for transport when properly packaged
- Waste Disposal: Dispose of in compliance with pharmaceutical waste regulations
6. Environmental & Health Impact
- Ecotoxicity: Low environmental toxicity; avoid release into waterways
- Persistence: Biodegradable under environmental conditions
- Carcinogenicity: No known carcinogenic effects
- Biodegradability: Readily biodegradable
SAFETY HANDLING
- PPE: Wear gloves, safety goggles, and protective clothing when handling powder or concentrated solutions.
- Handling: Avoid inhalation of dust and direct skin or eye contact; use in a well-ventilated area or fume hood.
- Storage: Keep container tightly closed; protect from moisture and heat.
- Hygiene: Wash hands thoroughly after handling; avoid eating, drinking, or smoking during handling.
First Aid Measures
- Inhalation: Move affected person to fresh air. Seek medical attention if breathing difficulty occurs.
- Skin Contact: Wash skin thoroughly with soap and water. If irritation or allergic reaction develops, seek medical advice.
- Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes. Seek medical help if irritation persists.
- Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel. Seek immediate medical attention.
Firefighting Measures
- Fire Hazards: Not flammable but may decompose under intense heat producing toxic fumes.
- Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguisher.
- Precautions: Firefighters should use self-contained breathing apparatus due to potential hazardous decomposition products.
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