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Cetomacrogel 1000BP
Cetomacrogel 1000BP is a high molecular weight polyethylene glycol (PEG) derivative, typically used as a thickening agent, emulsifier, and stabilizer in pharmaceutical and cosmetic formulations. It appears as a white to off-white, waxy solid or flakes with a neutral odor. Known for its excellent water solubility and compatibility with various ingredients, Cetomacrogel 1000BP enhances texture, viscosity, and stability in creams, ointments, and gels. It serves as a hydrophilic vehicle base in topical and oral pharmaceutical preparations and improves product spreadability and skin feel.
Cetomacrogel 1000BP
Primary Uses
- Pharmaceuticals
- Used as a hydrophilic base and thickener in topical ointments, creams, and gels.
- Functions as a solubilizer and stabilizer in liquid and semi-solid pharmaceutical formulations.
- Acts as a binder and matrix former in oral and topical drug delivery systems.
- Employed in suppository bases due to its water-soluble and melting properties.
- Cosmetics & Personal Care
- Used in moisturizing creams, lotions, and gels to enhance viscosity and texture.
- Acts as an emulsifier and stabilizer in oil-in-water emulsions.
- Provides a smooth, non-greasy skin feel and improves product spreadability.
Secondary Uses
- Industrial Applications
- Utilized in lubricant formulations to improve consistency and performance.
- Applied in textile and paper industries as a thickening and binding agent.
- Food Industry
- Occasionally used as a processing aid or carrier for flavor and colorants under regulatory approvals.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Polyethylene glycol (PEG) with average molecular weight ~1000 Da
- Common/Trade Name: Cetomacrogel 1000BP
- CAS Number: 25322-68-3 (for PEG 1000)
- HS Code: 3907.99.00
- Molecular Formula: (C2H4O)nH2O, where n corresponds to molecular weight approx. 1000 Da
- Synonyms:
- PEG 1000
- Polyethylene glycol 1000
- Macrogol 1000
2. Physical & Chemical Properties
- Physical State: White to off-white solid flakes or waxy granules
- Color & Odor: White to pale; odorless or faintly characteristic odor
- Melting Point: 37–40°C (softens and melts)
- Boiling Point: Not applicable (decomposes on heating)
- Density: ~1.13 g/cm³ at 20°C
- Solubility:
- Completely soluble in water
- Soluble in alcohols and glycols
- Insoluble in hydrocarbons and oils
- Stability: Stable under normal storage conditions; hygroscopic
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous
- NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
- Exposure Limits: No established limits; generally considered safe
- Toxicity: Low toxicity; widely used in pharmaceuticals and cosmetics safely
- Irritation Potential: Non-irritating to skin and eyes under normal use
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, tightly closed to prevent moisture uptake
- Container Type: Supplied in sealed bags, drums, or pails
- Shelf Life: Typically 3 years if stored properly
- Special Handling: Avoid dust generation; use PPE as needed
5. Regulatory & Compliance Attributes
- Pharmacopoeial Status: Complies with BP (British Pharmacopoeia) standards
- Cosmetic Regulatory Status: Approved for use in cosmetic formulations globally
- REACH Status: Registered
- Transportation: Not regulated as hazardous material
- Waste Disposal: Dispose according to local regulations; biodegradable
6. Environmental & Health Impact
- Ecotoxicity: Low; biodegradable and environmentally friendly
- Persistence: Readily biodegradable in the environment
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: Readily biodegradable
Safety Handling Precautions
- PPE: Use gloves and dust mask if handling large quantities or powders
- Handling: Avoid inhalation of dust; ensure adequate ventilation
- Storage: Keep container sealed and protected from moisture
- Hygiene: Wash hands after handling; do not eat or drink in handling area
First Aid Measures
- Inhalation: Move to fresh air if dust inhaled; seek medical attention if symptoms persist
- Skin Contact: Wash skin with water; no expected adverse effects
- Eye Contact: Rinse with plenty of water; seek medical attention if irritation occurs
- Ingestion: Non-toxic; rinse mouth and seek medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible at high temperatures
- Extinguishing Media: Water spray, foam, dry chemical, CO₂
- Special Precautions: Firefighters should use protective equipment
- Decomposition Products: May produce carbon monoxide, carbon dioxide, and other toxic fumes
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Diethanolamine
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