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Chlorhexidine Digluconate
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Chlorhexidine Digluconate is a concentrated aqueous solution of chlorhexidine salt (digluconate form), a potent broad-spectrum antimicrobial agent. It is a clear to slightly yellow viscous liquid with a mild characteristic odor. This antiseptic and disinfectant is widely used in medical, personal care, and industrial applications for its ability to effectively kill bacteria, fungi, and some viruses by disrupting microbial cell membranes. Chlorhexidine Digluconate is valued for its residual antimicrobial activity, low toxicity, and compatibility with various formulations.
Description
Chlorhexidine Digluconate Uses
Primary UsesÂ
Healthcare and Medical
- Used as a surgical scrub and skin antiseptic to reduce microbial flora before invasive procedures.
- Employed in oral care products such as mouthwashes and dental gels to control plaque and gingivitis.
- Utilized in wound care and antiseptic creams to prevent infections.
- Incorporated in hand sanitizers and disinfectants for healthcare workers and patient environments.
Personal Care
- Formulated into skin cleansers, deodorants, and feminine hygiene products for antimicrobial protection.
- Used in baby wipes and sanitizing wipes for effective microbial control without harsh chemicals.
Industrial Applications
- Used in disinfectants and sanitizers for surfaces in food processing and pharmaceutical manufacturing.
- Applied in water treatment systems as a biocide to control microbial contamination.
Secondary UsesÂ
Veterinary Medicine
- Used in antiseptic treatments for animals, including preoperative skin preparation and wound cleansing.
Textile Industry
- Incorporated into antimicrobial textile treatments to inhibit bacterial growth and odors in fabrics.
Cosmetics
- Included in preservative systems for cosmetic formulations to enhance microbial stability.
PRODUCT KEY FEATURES
- Basic Identification Attributes
- Chemical Name (IUPAC): 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] digluconate
- Common/Trade Name: Chlorhexidine Digluconate 20%
- CAS Number: 18472-51-0
- HS Code: 3808.94.00
- Molecular Formula: C22H30Cl2N10·2C6H12O7 (digluconate salt)
- Molecular Weight: 898.77 g/mol (digluconate salt)
- Synonyms:
- CHG 20%
- Chlorhexidine gluconate solution
- Physical & Chemical Properties
- Physical State: Viscous liquid
- Color & Odor: Clear to slightly yellow; mild characteristic odor
- pH: Typically 5.5 – 7.0
- Solubility: Completely soluble in water
- Density: Approximately 1.05 g/cm³ at 20°C
- Stability: Stable under normal storage conditions; sensitive to strong oxidizers
- Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous under normal use; may cause skin and eye irritation
- NFPA Ratings:
- Health: 2
- Flammability: 0
- Reactivity: 0
- Exposure Limits: Avoid prolonged skin contact and inhalation of aerosols
- Toxicity: Low toxicity; safe at recommended concentrations
- Reactivity: Stable; avoid contact with strong oxidizing agents
- Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place away from direct sunlight and incompatible materials
- Container Type: Polyethylene or glass containers with tight seals
- Shelf Life: Typically 2 years if stored properly
- Special Handling: Use gloves and eye protection; avoid aerosol formation
- Regulatory & Compliance Attributes
- FDA Status: Approved for use in antiseptic and disinfectant products
- REACH Status: Registered
- Transportation: Not regulated as hazardous material
- Waste Disposal: Dispose according to local regulations; avoid release into waterways
- Environmental & Health Impact
- Ecotoxicity: Moderate toxicity to aquatic organisms; avoid discharge into environment
- Persistence: Biodegradable under aerobic conditions
- Bioaccumulation: Low potential for bioaccumulation
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Biodegradability: Readily biodegradable
SAFETY HANDLING PRECAUTIONS
-
Safety Handling Precautions
- PPE: Use gloves, goggles, and protective clothing during handling
- Handling: Avoid skin and eye contact; do not ingest; work in well-ventilated areas
- Storage: Keep container tightly closed; store away from incompatible substances
- Hygiene: Wash hands thoroughly after use; do not eat, drink, or smoke while handling
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory irritation occurs
- Skin Contact: Wash affected area with plenty of water and soap; seek medical advice if irritation develops
- Eye Contact: Rinse cautiously with water for several minutes; seek medical attention if irritation persists
- Ingestion: Do not induce vomiting; rinse mouth and seek immediate medical attention
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, or dry chemical extinguishers as appropriate for surrounding fire
- Special Precautions: Firefighters should wear protective gear and self-contained breathing apparatus if necessary
- Decomposition Products: May release toxic gases such as hydrogen chloride if heated to decomposition
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