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Chlorocresol BP (PCMC)
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Chlorocresol BP, also known as PCMC (Para-Chlorometa-Cresol), is a white to off-white crystalline powder with a characteristic phenolic odor. It is a chlorinated phenol derivative widely used as a broad-spectrum antimicrobial preservative. It exhibits effective bactericidal and fungicidal activity, making it a preferred preservative in pharmaceutical, cosmetic, and personal care products. Chlorocresol is valued for its stability, solubility in aqueous and alcoholic systems, and compatibility with various formulation types. It helps inhibit microbial growth, thereby enhancing product shelf life and safety.
Description
Chlorocresol BP (PCMC) Uses
Primary UsesÂ
Pharmaceuticals
- Used as a preservative in topical creams, ointments, lotions, and injectables to prevent bacterial and fungal contamination.
- Incorporated in ophthalmic solutions and ear drops for antimicrobial protection.
- Added to antiseptic formulations for enhanced efficacy against pathogens.
Cosmetics & Personal Care
- Employed in skin care products, hair care formulations, and deodorants as a preservative.
- Used in bath preparations and mouthwashes to inhibit microbial growth.
Secondary UsesÂ
Veterinary Medicine
- Used in veterinary topical and ophthalmic products for antimicrobial protection.
Industrial Applications
Incorporated in some industrial antiseptic and cleaning products where microbial contamination control is needed.
PRODUCT KEY FEATURES
- Basic Identification Attributes
- Chemical Name (IUPAC): 4-Chloro-3-methylphenol
- Common/Trade Name: Chlorocresol BP, PCMC
- CAS Number: 59-50-7
- HS Code: 2907.30.00
- Molecular Formula: C7H7ClO
- Synonyms:
- Para-Chlorometa-Cresol
- Chlorocresol
- PCMC
- Physical & Chemical Properties
- Physical State: Crystalline powder
- Color & Odor: White to off-white; characteristic phenolic odor
- Melting Point: 64–68°C
- Boiling Point: Approx. 240°C (decomposes)
- Density: ~1.35 g/cm³
- Solubility: Slightly soluble in water; soluble in ethanol, ether, and oils
- Stability: Stable under normal storage; sensitive to light and heat
- Safety & Hazard Attributes
- Hazard Class (GHS): Harmful if swallowed or inhaled; irritant to skin and eyes
- NFPA Ratings:
- Health: 2
- Flammability: 2
- Reactivity: 0
- Exposure Limits: Avoid inhalation and prolonged skin contact; use adequate ventilation
- Toxicity: Moderate toxicity; may cause skin sensitization and irritation
- Reactivity: Stable but avoid strong oxidizers and acids
- Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, dark place in tightly closed containers
- Container Type: Sealed glass or high-density polyethylene containers
- Shelf Life: Typically 2-3 years under proper conditions
- Special Handling: Use PPE including gloves, goggles, and protective clothing; avoid dust generation
- Regulatory & Compliance Attributes
- Pharmacopoeial Status: Complies with British Pharmacopoeia (BP) standards
- FDA Status: Approved as a preservative in pharmaceuticals and cosmetics
- REACH Status: Registered under EU regulations
- Transportation: Not classified as hazardous under normal transport conditions
- Waste Disposal: Dispose according to local environmental and hazardous waste regulations
- Environmental & Health Impact
- Ecotoxicity: Toxic to aquatic organisms; avoid release to waterways
- Persistence: Degrades slowly in the environment
- Bioaccumulation: Not expected to bioaccumulate significantly
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Biodegradability: Moderate biodegradability under aerobic conditions
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
- PPE: Chemical-resistant gloves, eye protection, lab coat, and respiratory protection if dust is present
- Handling: Avoid inhalation, skin, and eye contact; handle in well-ventilated areas
- Storage: Keep container tightly sealed and away from incompatible substances
- Hygiene: Wash hands after handling; do not eat, drink, or smoke in work areas
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms persist
- Skin Contact: Wash with soap and water; seek medical advice if irritation occurs
- Eye Contact: Flush immediately with water for 15 minutes; seek medical help
- Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Combustible; may emit toxic fumes including chlorine-containing gases upon decomposition
- Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguishers
- Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus
Decomposition Products: Chlorine-containing gases, carbon monoxide, carbon dioxide
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