Chlorocresol BP (PCMC)

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Chlorocresol BP, also known as PCMC (Para-Chlorometa-Cresol), is a white to off-white crystalline powder with a characteristic phenolic odor. It is a chlorinated phenol derivative widely used as a broad-spectrum antimicrobial preservative. It exhibits effective bactericidal and fungicidal activity, making it a preferred preservative in pharmaceutical, cosmetic, and personal care products. Chlorocresol is valued for its stability, solubility in aqueous and alcoholic systems, and compatibility with various formulation types. It helps inhibit microbial growth, thereby enhancing product shelf life and safety.

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Category: Preservatives Tags: Antimicrobial preservative, Antiseptic agent, Chlorocresol BP, Pharmaceutical preservative, White to pale yellow powder

Description

Chlorocresol BP (PCMC) Uses

Table of Contents

Primary Uses

Pharmaceuticals

Used as a preservative in topical creams, ointments, lotions, and injectables to prevent bacterial and fungal contamination.
Incorporated in ophthalmic solutions and ear drops for antimicrobial protection.
Added to antiseptic formulations for enhanced efficacy against pathogens.

Cosmetics & Personal Care

Employed in skin care products, hair care formulations, and deodorants as a preservative.
Used in bath preparations and mouthwashes to inhibit microbial growth.

Secondary Uses

Veterinary Medicine

Used in veterinary topical and ophthalmic products for antimicrobial protection.

Industrial Applications

Incorporated in some industrial antiseptic and cleaning products where microbial contamination control is needed.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): 4-Chloro-3-methylphenol
Common/Trade Name: Chlorocresol BP, PCMC
CAS Number: 59-50-7
HS Code: 2907.30.00
Molecular Formula: C7H7ClO
Synonyms:
- Para-Chlorometa-Cresol
- Chlorocresol
- PCMC

Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; characteristic phenolic odor
Melting Point: 64–68°C
Boiling Point: Approx. 240°C (decomposes)
Density: ~1.35 g/cm³
Solubility: Slightly soluble in water; soluble in ethanol, ether, and oils
Stability: Stable under normal storage; sensitive to light and heat

Safety & Hazard Attributes

Hazard Class (GHS): Harmful if swallowed or inhaled; irritant to skin and eyes
NFPA Ratings:
- Health: 2
- Flammability: 2
- Reactivity: 0
Exposure Limits: Avoid inhalation and prolonged skin contact; use adequate ventilation
Toxicity: Moderate toxicity; may cause skin sensitization and irritation
Reactivity: Stable but avoid strong oxidizers and acids

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry, dark place in tightly closed containers
Container Type: Sealed glass or high-density polyethylene containers
Shelf Life: Typically 2-3 years under proper conditions
Special Handling: Use PPE including gloves, goggles, and protective clothing; avoid dust generation

Regulatory & Compliance Attributes

Pharmacopoeial Status: Complies with British Pharmacopoeia (BP) standards
FDA Status: Approved as a preservative in pharmaceuticals and cosmetics
REACH Status: Registered under EU regulations
Transportation: Not classified as hazardous under normal transport conditions
Waste Disposal: Dispose according to local environmental and hazardous waste regulations

Environmental & Health Impact

Ecotoxicity: Toxic to aquatic organisms; avoid release to waterways
Persistence: Degrades slowly in the environment
Bioaccumulation: Not expected to bioaccumulate significantly
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

Biodegradability: Moderate biodegradability under aerobic conditions

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE: Chemical-resistant gloves, eye protection, lab coat, and respiratory protection if dust is present
Handling: Avoid inhalation, skin, and eye contact; handle in well-ventilated areas
Storage: Keep container tightly sealed and away from incompatible substances
Hygiene: Wash hands after handling; do not eat, drink, or smoke in work areas

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms persist
Skin Contact: Wash with soap and water; seek medical advice if irritation occurs
Eye Contact: Flush immediately with water for 15 minutes; seek medical help
Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical attention

Firefighting Measures

Fire Hazards: Combustible; may emit toxic fumes including chlorine-containing gases upon decomposition
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus

Decomposition Products: Chlorine-containing gases, carbon monoxide, carbon dioxide