Hydrocortisone Base BP Micro

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Hydrocortisone Base BP Micro is a highly purified, micronized form of hydrocortisone base compliant with British Pharmacopoeia (BP) standards. It is a white to off-white fine powder designed for enhanced solubility and bioavailability in pharmaceutical formulations. As a corticosteroid hormone analog, it exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic activities. The micronized particle size (~93 microns) facilitates improved dispersion in topical, injectable, and oral dosage forms.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: BP 93 Grade, Fine Particle Size, Hydrocortisone Base, Micronized Hydrocortisone, Pharmaceutical Raw Material

Description

Table of Contents

Hydrocortisone Base BP Micro

Primary Uses

Pharmaceutical Industry

Used as an active ingredient in topical formulations such as creams, ointments, gels, and lotions for the treatment of inflammatory skin conditions including eczema, dermatitis, psoriasis, and allergic reactions.
Incorporated in injectable and oral dosage forms for systemic corticosteroid therapy to manage autoimmune diseases, allergic reactions, adrenal insufficiency, and inflammatory disorders.
Employed in ophthalmic preparations for eye inflammation and allergic conjunctivitis.
Used in compounding pharmacies to prepare customized corticosteroid therapies.

Veterinary Medicine

Utilized in veterinary formulations for treating inflammatory and allergic conditions in animals.

Secondary Uses

Cosmetic and Dermatological Research

Used in anti-inflammatory cosmetic formulations under strict regulatory controls for sensitive skin treatments.
Applied in research to study corticosteroid mechanisms of action and skin barrier modulation.

Combination Drug Formulations

Combined with antibiotics, antifungal agents, or local anesthetics to enhance therapeutic efficacy in multi-active topical treatments.

KET ATTRIBUTES

Basic Identification Attributes

Chemical Name (IUPAC): 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
Common/Trade Name: Hydrocortisone Base BP
CAS Number: 50-23-7
HS Code: 2937.29.00
Molecular Formula: C21H30O5
Synonyms: Cortisol; Hydrocortisone; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione

Physical & Chemical Properties

Physical State: Micronized powder (particle size ~93 microns)
Color & Odor: White to off-white; odorless or faint odor
Melting Point: 213–216 °C (decomposes)
Solubility: Practically insoluble in water; soluble in ethanol, acetone, and chloroform
Stability: Stable under recommended storage; sensitive to light and moisture

Safety & Hazard Attributes

GHS Classification: Not classified as hazardous; may cause irritation on contact
Toxicity: Low acute toxicity; systemic effects possible with long-term use
Exposure Limits: No specific occupational limits; general good hygiene recommended

Storage & Handling Attributes

Container Type: Airtight, moisture-proof containers such as glass or HDPE
Storage Conditions: Store in a cool, dry, dark environment away from light and moisture
Shelf Life: Typically 24 months under proper storage conditions
Handling Notes: Avoid dust inhalation; use adequate ventilation

Regulatory & Compliance Attributes

Compliant with British Pharmacopoeia (BP) standards
Approved for pharmaceutical use by major regulatory agencies including FDA and EMA
Usage controlled due to corticosteroid potency and side effect profiles

Environmental & Health Impact

Biodegradability: Moderate, steroid structure slows degradation
Ecotoxicity: Potential endocrine disruptor; environmental release should be minimized
Bioaccumulation: Not significant
Carcinogenicity/Mutagenicity: Not classified

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, dust mask, protective eyewear when handling powder
Handling Guidelines: Use in well-ventilated areas; avoid inhalation of dust and direct contact
Hygiene Practices: Wash hands thoroughly after handling; avoid eating or smoking during use

First Aid Measures

Inhalation: Move affected person to fresh air; seek medical advice if symptoms persist
Skin Contact: Wash thoroughly with soap and water; get medical attention if irritation occurs
Eye Contact: Rinse eyes with plenty of water for 15 minutes; consult physician if irritation continues
Ingestion: Rinse mouth; seek emergency medical care for significant ingestion

Firefighting Measures

Fire Hazards: Combustible powder; may emit toxic fumes such as carbon oxides on burning
Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide (CO₂)
Special Precautions: Firefighters should wear protective clothing and self-contained breathing apparatus (SCBA)