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Mepyramine Maleate BP
Mepyramine Maleate BP is an antihistamine drug commonly used to relieve allergic symptoms such as hay fever, urticaria, and other allergic reactions. It works by blocking histamine H1 receptors, reducing allergic responses like itching, swelling, and redness. This compound is a white or off-white crystalline powder, soluble in water and alcohol, widely used in pharmaceutical formulations including tablets, creams, and injectables.
Mepyramine Maleate BP
Primary Uses
- Allergy Treatment
- Used to treat hay fever, allergic rhinitis, and conjunctivitis.
- Alleviates symptoms such as sneezing, itching, runny nose, and watery eyes.
- Dermatological Applications
- Incorporated in topical creams and ointments for relief from itching, hives, and insect bites.
- Helps in managing urticaria and other allergic skin conditions.
- Cold and Flu Preparations
- Included in combination products to reduce allergic symptoms associated with colds.
- Pharmaceutical Formulations
- Used in oral tablets, capsules, syrups, and injectables for systemic antihistamine effect.
Secondary Uses
- Motion Sickness and Nausea
- Occasionally used off-label in some formulations for mild antiemetic effects.
- Veterinary Medicine
- Employed in treating allergic reactions in animals.
- Research Applications
- Used as a reference standard or reagent in pharmacological studies of H1 receptor antagonists.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-(4-Methoxyphenyl)-1-methylpyridin-2-amine maleate
- Common/Trade Name: Mepyramine Maleate BP
- CAS Number: 483-18-1
- HS Code: 2941.30.00
- Synonyms: Pyrilamine maleate; H1 receptor antagonist
2. Physical & Chemical Properties
- Physical State: Crystalline powder
- Color & Odor: White or off-white; odorless to faint odor
- Solubility: Soluble in water and alcohol
- Melting Point: 147–151°C (decomposes)
- Density: Approx. 1.3 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal handling
- Toxicity: Low to moderate toxicity; avoid ingestion and prolonged exposure
- Exposure Limits: Follow standard pharmaceutical handling protocols
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light
- Container Type: Supplied in sealed containers or pharmaceutical-grade packaging
- Shelf Life: Typically 24 months if stored properly
- Handling Precautions: Use gloves and dust masks; avoid inhalation and contact with skin and eyes
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Registered under relevant pharmaceutical and chemical safety regulations
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable
- Ecotoxicity: Low environmental impact when handled properly
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic
Safety Handling Precautions
- PPE Required: Gloves, safety goggles, and dust mask recommended
- Handling Guidelines: Use in well-ventilated areas; avoid dust generation and skin contact
- Storage Measures: Keep containers tightly closed and store away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory symptoms occur
- Skin Contact: Wash thoroughly with soap and water
- Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; seek medical attention if irritation persists
- Ingestion: Do not induce vomiting; seek medical advice immediately
Firefighting Measures
- Fire Hazards: Combustible powder
- Extinguishing Media: Use water spray, foam, dry chemical, or CO2 extinguishers
- Special Precautions: Avoid dust cloud formation; wear protective equipment
- Hazardous Combustion Products: May produce carbon oxides and nitrogen oxides under fire conditions
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