Carbocisteine AJI 92

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Carbocisteine AJI 92 is a high-purity pharmaceutical-grade amino acid derivative, chemically known as S-carboxymethyl-L-cysteine. It is a white to off-white crystalline powder with a slightly sulfurous odor and is freely soluble in water. Carbocisteine functions primarily as a mucolytic agent—reducing the viscosity of mucus and promoting expectoration in respiratory tract infections. The “AJI 92” specification refers to its compliance with the purity standards established by Ajinomoto’s amino acid quality benchmarks, ensuring it meets stringent pharmaceutical-grade quality control for active pharmaceutical ingredients (APIs). It is widely used in oral syrups, tablets, and granules in both human and veterinary medicine.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Carbocysteine, Cough and cold remedies, Mucus thinner, Pharmaceutical formulations, Respiratory health supplements, White crystalline powder

Description

Table of Contents

Carbocisteine AJI 92

Primary Uses

Pharmaceuticals

Mucolytic Agent: Used in the treatment of respiratory conditions such as chronic bronchitis, COPD, and sinusitis to break down mucus and ease expectoration.
Formulations: Commonly found in syrups, effervescent tablets, granules, and capsules for both adult and pediatric use.
Adjunctive Therapy: Sometimes used in combination with antibiotics or bronchodilators for enhanced respiratory support.
Otolaryngology: Used to manage secretory otitis media and other ENT conditions with mucus overproduction.

Veterinary Medicine

Employed in veterinary treatments for respiratory diseases in livestock and pets, functioning similarly as a mucolytic.
Included in oral powders and liquids for animals suffering from bronchopulmonary congestion.

Secondary Uses

Nutritional Supplements

Occasionally formulated into dietary supplements for individuals with chronic respiratory issues.

Medical Research

Studied for its anti-inflammatory and antioxidant properties in experimental treatments for gastrointestinal and respiratory tract disorders.

Cosmeceuticals (Experimental)

Investigated for potential applications in hair care products due to its sulfur-containing structure related to keratin interaction.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (2R)-2-Amino-3-[(carboxymethyl)sulfanyl]propanoic acid
Common/Trade Name: Carbocisteine
CAS Number: 638-23-3
HS Code: 2930.90.99
Molecular Formula: C5H9NO4S
Molecular Weight: 179.19 g/mol
Synonyms:
- S-Carboxymethyl-L-cysteine
- L-Carbocisteine
- SCMC
- L-2-Amino-3-carboxymethylthio propionic acid

2. Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; faint sulfur-like odor
Melting Point: ~210–220°C (with decomposition)
Solubility:
- Freely soluble in water
- Practically insoluble in ethanol and ether
pH (1% solution): Approx. 2.2 – 3.0
Optical Rotation: +20.0° to +22.5° (20°C, c=1 in H₂O)
Stability: Stable under recommended storage conditions
Loss on Drying: ≤ 0.2%
Purity (AJI 92 Standard): ≥ 98.5% (on dry basis)

3. Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous
NFPA Ratings:
- Health: 1
- Flammability: 0
- Reactivity: 0
Exposure Limits: Not established
Toxicity: Low acute toxicity; LD₅₀ (oral, rat): >2000 mg/kg
Reactivity: Stable and non-reactive under normal handling

4. Storage & Handling Attributes

Storage Conditions: Store in a tightly sealed container in a cool, dry place away from light and moisture
Container Type: Double-lined fiber drums or HDPE containers with desiccant lining
Shelf Life: Typically 3–5 years when stored properly
Special Handling: Avoid dust formation; handle in well-ventilated areas

5. Regulatory & Compliance Attributes

Pharmacopoeial Status:
- Complies with AJI 92 (Ajinomoto amino acid standards)
- Listed in European Pharmacopoeia (Ph. Eur.), Japanese Pharmacopoeia (JP), and Indian Pharmacopoeia (IP)
FDA Status: Approved API in multiple formulations; not available OTC in all markets
REACH Status: Not classified as hazardous; exempt or pre-registered
Transportation: Not regulated as hazardous
Waste Disposal: Dispose according to local, regional, national, and international regulations

6. Environmental & Health Impact

Ecotoxicity: Not expected to pose significant risk to aquatic or terrestrial organisms
Persistence: Biodegradable
Bioaccumulation: Not expected to bioaccumulate
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Biodegradability: Readily biodegradable

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

Personal Protective Equipment (PPE):

Protective gloves
Safety goggles
Dust mask or respirator (if handling powder in bulk)
Lab coat or cleanroom garments

Handling Measures:

Minimize dust generation
Use local exhaust ventilation if necessary
Avoid ingestion and inhalation

Storage Measures:

Keep tightly sealed
Protect from light, moisture, and excessive heat
Use FIFO system

Hygiene Practices:

Wash hands before eating or drinking
Avoid touching eyes or mouth after handling
Clean work surfaces thoroughly

First Aid Measures

Inhalation: Move to fresh air. Seek medical attention if symptoms persist.
Skin Contact: Wash with soap and water. Get medical advice if irritation develops.
Eye Contact: Rinse with water for at least 15 minutes. Seek medical help if discomfort continues.
Ingestion: Rinse mouth. Do not induce vomiting. Seek medical attention if large quantity is ingested.

Firefighting Measures

Fire Hazards: Non-flammable but may decompose under heat to release sulfur oxides and nitrogen oxides
Extinguishing Media: Use water spray, CO₂, dry chemical, or foam
Special Precautions: Wear full protective gear and self-contained breathing apparatus
Decomposition Products: CO, CO₂, SOx, NOx