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Cellulose Acetate Phthalate (CAP)
Cellulose Acetate Phthalate (CAP) is a cellulose derivative obtained by esterification of cellulose with acetic acid and phthalic anhydride. It appears as a white to off-white, free-flowing powder that is insoluble in water but soluble in alkaline solutions and certain organic solvents. CAP is primarily used as an enteric coating agent in pharmaceutical formulations, providing resistance to acidic gastric fluids and enabling targeted release of drugs in the intestines. Due to its film-forming, pH-sensitive solubility, and protective properties, CAP is also applied in food, cosmetics, and specialty industrial uses.
Cellulose Acetate Phthalate (CAP)
Primary Uses
- Pharmaceutical Industry
- Widely used as an enteric coating polymer for tablets and capsules to prevent dissolution in stomach acid and enable targeted release in the intestines.
- Provides protection for acid-sensitive drugs and reduces gastric irritation.
- Acts as a controlled-release film former in oral dosage forms.
- Food Industry
- Used as a coating agent for confectionery and food products to provide gloss and protective barriers.
- Functions as a controlled-release matrix for flavor and nutrient encapsulation.
- Cosmetics
- Employed in nail polish formulations and other cosmetics for film-forming and gloss-enhancing properties.
- Provides water-resistant coatings.
Secondary Uses
- Packaging Industry
- Utilized in specialty coatings for biodegradable films and packaging materials for controlled permeability.
- Adhesives & Sealants
- Applied as a component in water-resistant adhesives and sealants.
- Printing Industry
- Used in inks and coatings to improve film durability and chemical resistance.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Cellulose, acetate, phthalate
- Common/Trade Name: Cellulose Acetate Phthalate, CAP
- CAS Number: 9004-35-7
- HS Code: 3912.10.00
- Molecular Formula: Variable (cellulose backbone with acetate and phthalate ester substitutions)
- Synonyms:
- CAP
- Cellulose acetate phthalate polymer
- Phthalylated cellulose acetate
2. Physical & Chemical Properties
- Physical State: White to off-white powder
- Color & Odor: White/off-white; virtually odorless
- Melting Point: Decomposes before melting
- Boiling Point: Not applicable
- Density: Approximately 1.3–1.4 g/cm³
- Solubility:
- Insoluble in water and gastric acid (pH <3)
- Soluble in alkaline conditions (pH >6)
- Soluble in acetone, ethanol, and certain organic solvents
- pH Sensitivity: Dissolves at intestinal pH (around 6.8 and above)
- Stability: Stable under dry, cool storage conditions; sensitive to strong acids and bases
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous under normal use
- NFPA Ratings:
- Health: 0
- Flammability: 1 (combustible dust risk)
- Reactivity: 0
- Exposure Limits: No specific occupational exposure limits; general dust precautions advised
- Toxicity: Non-toxic; widely regarded as safe for pharmaceutical and food uses
- Reactivity: Stable under normal conditions; avoid strong oxidizers and acids
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place away from moisture and direct sunlight
- Container Type: Sealed, moisture-proof containers or bags (plastic or foil-lined)
- Shelf Life: Typically 2–3 years if stored properly
- Special Handling: Avoid dust generation and inhalation; use PPE when handling powders
5. Regulatory & Compliance Attributes
- FDA Status: Approved as a pharmaceutical excipient and food additive in regulated uses
- REACH Status: Registered
- Transportation: Not regulated as hazardous material
- Waste Disposal: Dispose according to local regulations; biodegradable under industrial composting
6. Environmental & Health Impact
- Ecotoxicity: Low environmental impact; biodegradable under aerobic conditions
- Persistence: Moderate biodegradability; slow in some conditions
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: Biodegradable, but may require controlled conditions
Safety Handling Precautions
Personal Protective Equipment (PPE):
- Dust mask or respirator for powder handling
- Safety goggles
- Gloves recommended
Handling Measures:
- Avoid dust formation and accumulation
- Use in well-ventilated areas
- Prevent contact with strong acids or oxidizers
Storage Measures:
- Keep containers tightly sealed and dry
- Store away from heat and ignition sources
Hygiene Practices:
- Wash hands after handling
- Avoid eating, drinking, or smoking while handling product
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if irritation occurs
- Skin Contact: Wash with soap and water; seek medical advice if irritation persists
- Eye Contact: Flush with water for 15 minutes; seek medical attention if irritation continues
- Ingestion: Non-toxic; rinse mouth and seek medical advice if large quantities ingested
Firefighting Measures
- Fire Hazards: Combustible powder; may produce dust explosion hazard
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Avoid dust accumulation; firefighters should wear protective equipment and respiratory protection
- Decomposition Products: Carbon oxides, phthalic anhydride, and acetic acid vapors under thermal decomposition
Related products
Ammonia Acetate
Ammonia Acetate is a white crystalline solid or granular powder with a mild ammoniacal odor. It is a salt formed from ammonia and acetic acid, widely used in laboratories, industrial processes, and some niche food and pharmaceutical applications. Ammonium Acetate is highly soluble in water and often utilized as a buffer solution in biochemical and analytical chemistry due to its ability to maintain pH. It also serves as a precursor in the synthesis of various chemicals and acts as a neutralizing agent in several industrial applications.
Bitter Masking Pharmaceutical Liquid flavors
Bitter Masking Pharmaceutical Liquid Flavors are specially formulated liquid flavors designed to mask the bitter taste of active pharmaceutical ingredients (APIs). These flavors improve the palatability of oral syrups, suspensions, and liquid medications, enhancing patient compliance. Compatible with various pharmaceutical formulations, they exhibit excellent solubility and stability in aqueous systems and provide a pleasant taste profile without affecting the efficacy of the medication.
Cetomacrogol PEG1000 (Ginonic CSA 20)
Cetomacrogol PEG (Ginonic CSA) is a polyethylene glycol-based nonionic surfactant and emulsifier with an average molecular weight of approximately 1000 Da. It appears as a white to off-white waxy solid or flakes with a neutral odor. This high-quality grade is widely used in cosmetic, pharmaceutical, and personal care formulations due to its excellent emulsifying, solubilizing, and moisturizing properties. Cetomacrogol PEG1000 (Ginonic CSA 20) facilitates stable oil-in-water emulsions, improves product texture and skin feel, and enhances the bioavailability of active ingredients. Its hydrophilic nature and compatibility with a wide range of ingredients make it a versatile additive in creams, lotions, ointments, and topical gels.
Dicalcium Phosphate
Dicalcium Phosphate (DCP) is an inorganic compound commonly used as a dietary supplement, food additive, and a key raw material in pharmaceuticals and animal nutrition. It appears as a white crystalline powder or granules and provides a highly bioavailable source of calcium and phosphorus, essential minerals for bone health, metabolic functions, and overall growth. DCP is widely used in the feed industry, pharmaceutical manufacturing, food processing, and various industrial applications, appreciated for its purity, stability, and nutritional value.
Dicalcium Phosphate Dihydrate
Dicalcium Phosphate Dihydrate (DCP Dihydrate) is an odorless, white crystalline powder or granule composed of calcium and phosphate in a hydrated form. It is widely used in the pharmaceutical, food, animal feed, and industrial sectors. It serves as a calcium and phosphorus supplement, excipient, and abrasive agent, valued for its stability, bioavailability, and neutral taste. DCP Dihydrate complies with various pharmacopeial standards (e.g., USP, BP, FCC) depending on the grade.
Lactose Monohydrate 200 Mesh
Lactose Monohydrate 200 Mesh is a fine, white, crystalline powder derived from milk sugar with a particle size of 200 mesh, indicating very fine granules. It is widely used in pharmaceutical, food, and confectionery industries as a filler, binder, and stabilizer. Lactose Monohydrate is valued for its excellent compressibility, low hygroscopicity, and compatibility with many active pharmaceutical ingredients (APIs). The monohydrate form contains one molecule of water, enhancing its stability and flow properties.
Methyl Cellulose 400mpc
Methyl Cellulose 400mpc is a chemically modified cellulose derivative in powder form. It is a non-ionic, water-soluble polymer widely used as a thickener, binder, emulsifier, and film former. It exhibits excellent water retention, viscosity control, and thermal gelation properties, making it ideal for applications in construction, pharmaceuticals, food, and cosmetics.
Polyethyl Glycol( PEG 6000)
Polyethyl Glycol( PEG 6000) is a high-molecular-weight polymer derived from ethylene oxide. It appears as a white, waxy solid or flake and is non-toxic, water-soluble, and chemically stable. PEG 6000 is widely used in pharmaceuticals, cosmetics, food processing, industrial formulations, and biotechnology, valued for its lubricating, solubilizing, binding, and moisturizing properties. It is odorless and tasteless, making it suitable for sensitive formulations.
