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Metronidazole BP
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Metronidazole BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Description
Metronidazole BP
Primary UsesÂ
- Antiprotozoal Therapy
- Treatment of amoebiasis (intestinal and hepatic).
- Management of giardiasis (Giardia lamblia infections).
- Used in trichomoniasis (vaginal and urethral infections).
- Antibacterial Therapy
- Active against anaerobic bacteria (e.g., Bacteroides, Clostridium).
- Used in bacterial vaginosis and pelvic inflammatory disease (PID).
- Prophylaxis in colorectal and gynecological surgeries.
- Helicobacter pylori Eradication
- Part of triple/quadruple therapy for peptic ulcers.
Secondary UsesÂ
- Veterinary Medicine
- Treatment of anaerobic infections in dogs and cats.
- Used in fish farming to control protozoan parasites.
- Dermatology
- Topical formulations for rosacea and acneiform eruptions.
- Dental Infections
- Adjunct therapy for acute necrotizing ulcerative gingivitis (ANUG).
KEY PRODUCT FEATURES
Key Attributes
Basic Identification Attributes
- Chemical Name (IUPAC): 2-Methyl-5-nitro-1H-imidazole-1-ethanol benzoate
- Common/Trade Name: Metronidazole Benzoate BP
- CAS Number: 13182-89-3
- HS Code: 2933.29.90 (Other heterocyclic compounds)
- Synonyms: Metronidazole benzoate ester; Flagyl benzoate
Physical & Chemical Properties
- Physical State: White to pale yellow crystalline powder
- Color & Odor: Odorless or faint characteristic odor
- Melting Point: ~98–102°C
- Solubility:
- Slightly soluble in water
- Freely soluble in methanol, ethanol, chloroform
- pH: Neutral (~6.0–7.5 in suspension)
Safety & Hazard Attributes
- GHS Classification:
- H302 (Harmful if swallowed)
- H315 (Causes skin irritation)
- H319 (Causes serious eye irritation)
- H335 (May cause respiratory irritation)
- Toxicity: Low acute toxicity; avoid prolonged exposure
- Exposure Limits: No specific OEL; handle as pharmaceutical powder
Storage & Handling Attributes
- Storage Conditions:
- Store in tightly sealed containers at ≤25°C.
- Protect from light and moisture.
- Container Type: Amber glass or HDPE containers.
- Shelf Life: Typically 24–36 months if stored properly.
- Handling Precautions:
- Use gloves, mask, and goggles.
- Avoid dust formation.
Regulatory & Compliance Attributes
- Complies with:
- British Pharmacopoeia (BP) standards.
- USP/NF (if applicable for formulations).
- ICH Q7 (GMP for APIs).
- Regulatory Status:
- Prescription-only drug in most countries.
Environmental & Health Impact
- Biodegradability: Readily biodegradable.
- Ecotoxicity: Low risk; no significant bioaccumulation.
- Carcinogenicity/Mutagenicity:
- Not classified (metronidazole is a possible carcinogen with chronic exposure).
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
- PPE Required:
- Nitrile gloves, dust mask, lab coat, safety goggles.
- Handling Guidelines:
- Use in well-ventilated areas.
- Avoid contact with skin/eyes.
- Storage Measures:
- Keep away from strong oxidizers.
First Aid Measures
- Inhalation: Move to fresh air; seek medical help if irritation persists.
- Skin Contact: Wash with soap and water; remove contaminated clothing.
- Eye Contact: Rinse with water for 15 mins; consult ophthalmologist.
- Ingestion: Rinse mouth; do NOT induce vomiting; seek medical attention.
Firefighting Measures
- Fire Hazards: Non-flammable but may decompose at high temperatures.
- Extinguishing Media: Use water spray, COâ‚‚, or dry chemical.
- Hazardous Combustion Products: Nitrogen oxides (NOx), CO, COâ‚‚.
Related products
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Methanol, also known as methyl alcohol or wood alcohol, is a clear, colorless, volatile, and flammable liquid with a distinct alcoholic odor. It is the simplest alcohol and is widely used as an industrial solvent, antifreeze, fuel, and chemical feedstock. Methanol is highly miscible with water and many organic solvents and serves as a precursor to numerous chemicals including formaldehyde, acetic acid, and various plastic
Polyethylene Glycol (PEG 6000)
Polyethylene Glycol 6000 (PEG 6000) is a high-molecular-weight polymer derived from ethylene oxide. It appears as a white, waxy solid or flake and is non-toxic, water-soluble, and chemically stable. PEG 6000 is widely used in pharmaceuticals, cosmetics, food processing, industrial formulations, and biotechnology, valued for its lubricating, solubilizing, binding, and moisturizing properties. It is odorless and tasteless, making it suitable for sensitive formulations.
Polyvinyl Alcohol
Polyvinyl Alcohol is a synthetic, water-soluble polymer made by the hydrolysis of polyvinyl acetate. It is known for excellent film-forming, emulsifying, and adhesive properties. PVA is widely used across industries for applications requiring biodegradable, non-toxic, and flexible materials. It offers good chemical resistance, mechanical strength, and compatibility with other polymers and additives.
Potassium Iodide
Potassium Iodide is a white, crystalline inorganic salt that serves as a vital source of iodine. It is widely used in medical, pharmaceutical, nutritional, and industrial fields. Potassium Iodide is highly soluble in water and is used both as a dietary supplement to prevent iodine deficiency and as a protective agent against radioactive iodine exposure. It also finds applications in chemical synthesis and photographic processes.
Potassium Metabisulphite Food Grade
Potassium Metabisulphite (Food Grade) is a white crystalline powder with strong antioxidant and preservative properties. It is widely used in the food and beverage industry as a disinfectant, antioxidant, and preservative to prevent spoilage and microbial growth. It also acts as a bleaching agent and sulfur dioxide (SOâ‚‚) source. This compound is critical in winemaking, brewing, and food processing to maintain product quality and extend shelf life.
Povidone Iodine BP
Povidone Iodine BP is a water-soluble complex of iodine with the synthetic polymer polyvinylpyrrolidone (PVP). It acts as a broad-spectrum antiseptic effective against bacteria, fungi, viruses, and protozoa. Widely used in medical, pharmaceutical, and veterinary fields, Povidone Iodine provides sustained iodine release, minimizing irritation while offering rapid antimicrobial action. It is essential for wound care, surgical preparation, and infection control.
Povidone PVP25 USP
Povidone PVP25 USP is a synthetic polymer of vinylpyrrolidone with an average molecular weight of approximately 25,000. It is a water-soluble, non-toxic, and biodegradable polymer widely used as a binder, film former, stabilizer, and solubilizing agent in pharmaceutical, cosmetic, and industrial applications. Its excellent adhesive properties and compatibility with a wide range of substances make it essential in tablet formulations, topical products, and adhesives.
