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PVP K 90 USP
PVP K 90 USP (Polyvinylpyrrolidone K-90) is a high molecular weight water-soluble polymer widely used in pharmaceutical, cosmetic, and industrial applications. Known for its excellent film-forming, adhesive, and thickening properties, PVP K 90 is particularly valued where higher viscosity and stronger binding are required. This grade meets USP standards, ensuring purity and suitability for pharmaceutical use, especially in sustained-release formulations, suspensions, and topical products.
PVP K 90 USP
Primary Uses
- Pharmaceutical Industry
- Used as a binder in tablets and granules, providing enhanced mechanical strength due to its high molecular weight.
- Functions as a suspending and viscosity-increasing agent in liquid formulations and injectables.
- Employed in controlled-release formulations to regulate drug release kinetics.
- Acts as a film former for protective coatings on tablets and topical products.
- Cosmetics and Personal Care
- Utilized as a thickener, stabilizer, and film former in creams, lotions, shampoos, and hair styling products.
- Enhances moisture retention and skin feel in various skincare formulations.
- Industrial Applications
- Used as a dispersant and stabilizer in adhesives, inks, and paints.
- Applied in the formulation of photographic chemicals and other specialty products.
Secondary Uses
- Food Industry
- Occasionally used as a stabilizer and emulsifier under regulatory approval.
- Laboratory Uses
- Serves as a matrix component in biochemical and molecular biology research.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Poly(1-vinyl-2-pyrrolidone)
- Common/Trade Name: PVP K 90 USP
- CAS Number: 9003-39-8
- HS Code: 3906.90.10
- Synonyms: Polyvinylpyrrolidone K-90; Povidone K90
2. Physical & Chemical Properties
- Physical State: Fine white to off-white powder
- Solubility: Soluble in water and some polar solvents
- Molecular Weight: Approximately 360,000 Da (K value 90)
- pH (1% solution): 4.0 – 7.0
- Odor & Color: Odorless or slight characteristic odor; white powder
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous
- Toxicity: Low toxicity; generally non-irritant
- Exposure Limits: Follow occupational safety guidelines for dust
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from moisture and incompatible substances
- Container Type: Sealed bags or drums
- Shelf Life: 2–3 years if stored properly
- Handling Precautions: Avoid dust formation; use appropriate respiratory protection
5. Regulatory & Compliance Attributes
- Complies with USP monograph for Polyvinylpyrrolidone
- Generally Recognized As Safe (GRAS) for specified uses
- Manufactured under GMP conditions
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable
- Ecotoxicity: Low aquatic toxicity
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Dust mask, gloves, and eye protection recommended
- Handling Guidelines: Use in well-ventilated areas; minimize dust exposure
- Storage Measures: Keep containers tightly sealed and stored in a dry environment away from moisture
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if irritation occurs
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse eyes with plenty of water for 15 minutes; seek medical attention if needed
- Ingestion: Rinse mouth; consult a physician if large quantities ingested
Firefighting Measures
- Fire Hazards: Combustible dust may cause explosive atmospheres
- Extinguishing Media: Water spray, foam, dry chemical, CO₂
- Special Precautions: Avoid dust accumulation; use respiratory and protective clothing
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides
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