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Sulfadiazine Base BP
Sulfadiazine Base BP is a broad-spectrum sulfonamide antibiotic used primarily in veterinary and human medicine to treat bacterial infections. It functions by inhibiting bacterial synthesis of folic acid, thereby preventing bacterial growth and proliferation. The British Pharmacopoeia (BP) grade ensures pharmaceutical-grade purity and quality suitable for formulation into tablets, suspensions, and topical preparations.
Sulfadiazine Base BP
Primary Uses
- Human Medicine
- Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, and meningitis caused by susceptible bacteria.
- Topical Antimicrobial: Formulated in creams and ointments for treating burns and wound infections.
- Veterinary Medicine
- Animal Antibiotic: Used to treat infections in livestock and pets, including respiratory, urinary, and soft tissue infections.
- Feed Additive: Sometimes included in medicated feed for prophylactic or therapeutic purposes.
Secondary Uses
- Research & Development
- Microbiological Studies: Used in lab research to study bacterial resistance and antibiotic mechanisms.
- Pharmaceutical Formulation: Employed as a model drug in formulation development and bioavailability studies.
- Aquaculture
- Fish Medication: Used to control bacterial diseases in aquaculture under veterinary supervision.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide
- Common/Trade Name: Sulfadiazine Base BP
- CAS Number: 68-35-9
- HS Code: 2941.20.00
- Synonyms: Sulfadiazine, Sulfadiazine base
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White; odorless to faint sulfurous odor
- Melting Point: 254–258 °C (decomposes)
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents like ethanol
- Density: Approx. 1.65 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic reactions; handle with care
- Toxicity: Moderate; avoid inhalation and prolonged skin contact
- Exposure Limits: No specific occupational exposure limits but good industrial hygiene recommended
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated place, protected from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust generation; use appropriate PPE including gloves and masks
5. Regulatory & Compliance Attributes
- Conforms to British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Complies with relevant pharmaceutical regulatory requirements including ICH guidelines
6. Environmental & Health Impact
- Biodegradability: Limited data; sulfonamides generally degrade under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, lab coat, and dust mask recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash affected area with soap and water; discontinue use if irritation occurs
- Eye Contact: Flush with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice immediately
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
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