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Sulfadiazine Base BP
Sulfadiazine Base BP is a broad-spectrum sulfonamide antibiotic used primarily in veterinary and human medicine to treat bacterial infections. It functions by inhibiting bacterial synthesis of folic acid, thereby preventing bacterial growth and proliferation. The British Pharmacopoeia (BP) grade ensures pharmaceutical-grade purity and quality suitable for formulation into tablets, suspensions, and topical preparations.
Sulfadiazine Base BP
Primary Uses
- Human Medicine
- Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, and meningitis caused by susceptible bacteria.
- Topical Antimicrobial: Formulated in creams and ointments for treating burns and wound infections.
- Veterinary Medicine
- Animal Antibiotic: Used to treat infections in livestock and pets, including respiratory, urinary, and soft tissue infections.
- Feed Additive: Sometimes included in medicated feed for prophylactic or therapeutic purposes.
Secondary Uses
- Research & Development
- Microbiological Studies: Used in lab research to study bacterial resistance and antibiotic mechanisms.
- Pharmaceutical Formulation: Employed as a model drug in formulation development and bioavailability studies.
- Aquaculture
- Fish Medication: Used to control bacterial diseases in aquaculture under veterinary supervision.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide
- Common/Trade Name: Sulfadiazine Base BP
- CAS Number: 68-35-9
- HS Code: 2941.20.00
- Synonyms: Sulfadiazine, Sulfadiazine base
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White; odorless to faint sulfurous odor
- Melting Point: 254–258 °C (decomposes)
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents like ethanol
- Density: Approx. 1.65 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic reactions; handle with care
- Toxicity: Moderate; avoid inhalation and prolonged skin contact
- Exposure Limits: No specific occupational exposure limits but good industrial hygiene recommended
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated place, protected from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust generation; use appropriate PPE including gloves and masks
5. Regulatory & Compliance Attributes
- Conforms to British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Complies with relevant pharmaceutical regulatory requirements including ICH guidelines
6. Environmental & Health Impact
- Biodegradability: Limited data; sulfonamides generally degrade under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, lab coat, and dust mask recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash affected area with soap and water; discontinue use if irritation occurs
- Eye Contact: Flush with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice immediately
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
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Chloramphenicol Palmitate Micronised
Chloramphenicol Palmitate Micronised is a micronized, lipophilic ester derivative of chloramphenicol, designed for improved solubility and bioavailability compared to the parent drug. It appears as a fine, white to off-white powder with enhanced surface area due to micronization. This antibiotic is widely used for oral formulations, particularly pediatric suspensions, due to its palatability and controlled release properties. Chloramphenicol Palmitate exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Its ester form offers better stability and reduced bitterness, making it a preferred choice in pharmaceutical preparations.
Diloxanide Furoate
Diloxanide Furoate is an orally administered antiprotozoal agent used primarily for the treatment of amoebiasis. It is a furan-based derivative that acts as a luminal amoebicide, effectively targeting Entamoeba histolytica cysts and trophozoites within the intestinal lumen. This compound is well-regarded for its efficacy in eradicating asymptomatic cyst carriers and as a follow-up treatment after systemic amoebicidal therapy. Diloxanide Furoate has good oral bioavailability and a favorable safety profile.
Doxycycline Hyclate BP
Doxycycline Hyclate BP is a broad-spectrum, semisynthetic tetracycline-class antibiotic available as the hemihydrate salt form of doxycycline. It is widely used in pharmaceutical formulations due to its high bioavailability, broad antibacterial activity, and favorable pharmacokinetic profile. The compound exhibits bacteriostatic action by inhibiting protein synthesis in susceptible bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms as well as atypical pathogens. It is typically supplied as a fine, white to off-white crystalline powder soluble in water and suitable for oral and parenteral dosage forms.
Hydrocortisone Base BP 93 Micro
Hydrocortisone Base BP 93 Micro is a highly purified, micronized form of hydrocortisone base compliant with British Pharmacopoeia (BP) standards. It is a white to off-white fine powder designed for enhanced solubility and bioavailability in pharmaceutical formulations. As a corticosteroid hormone analog, it exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic activities. The micronized particle size (~93 microns) facilitates improved dispersion in topical, injectable, and oral dosage forms.
Ichthammol BP98
Ichthammol BP98, also known as ammonium bituminosulfonate, is a dark brown to black, viscous, sulfur-rich, semi-solid substance derived from the distillation of shale or bituminous rocks. It has a characteristic tar-like odor and is highly valued in pharmaceutical and dermatological applications for its anti-inflammatory, antiseptic, antipruritic (anti-itch), and keratolytic properties. Ichthammol penetrates deeply into the skin and soft tissues, helping to alleviate inflammation and promote healing. It is widely used in topical preparations for treating skin conditions such as eczema, psoriasis, boils, abscesses, and other dermatological infections.
Methyl Salicylate BP
Methyl Salicylate BP is a clear, colorless to pale yellow oily liquid with a characteristic strong, sweet, and minty odor. It is an organic ester commonly used for its analgesic, anti-inflammatory, and flavoring properties. Methyl Salicylate is widely used in pharmaceutical preparations, topical pain relief products, cosmetics, and as a fragrance ingredient.
Metronidazole BP
Metronidazole BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
