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Sulfadiazine Base BP
Sulfadiazine Base BP is a broad-spectrum sulfonamide antibiotic used primarily in veterinary and human medicine to treat bacterial infections. It functions by inhibiting bacterial synthesis of folic acid, thereby preventing bacterial growth and proliferation. The British Pharmacopoeia (BP) grade ensures pharmaceutical-grade purity and quality suitable for formulation into tablets, suspensions, and topical preparations.
Sulfadiazine Base BP
Primary Uses
- Human Medicine
- Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, and meningitis caused by susceptible bacteria.
- Topical Antimicrobial: Formulated in creams and ointments for treating burns and wound infections.
- Veterinary Medicine
- Animal Antibiotic: Used to treat infections in livestock and pets, including respiratory, urinary, and soft tissue infections.
- Feed Additive: Sometimes included in medicated feed for prophylactic or therapeutic purposes.
Secondary Uses
- Research & Development
- Microbiological Studies: Used in lab research to study bacterial resistance and antibiotic mechanisms.
- Pharmaceutical Formulation: Employed as a model drug in formulation development and bioavailability studies.
- Aquaculture
- Fish Medication: Used to control bacterial diseases in aquaculture under veterinary supervision.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide
- Common/Trade Name: Sulfadiazine Base BP
- CAS Number: 68-35-9
- HS Code: 2941.20.00
- Synonyms: Sulfadiazine, Sulfadiazine base
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White; odorless to faint sulfurous odor
- Melting Point: 254–258 °C (decomposes)
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents like ethanol
- Density: Approx. 1.65 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic reactions; handle with care
- Toxicity: Moderate; avoid inhalation and prolonged skin contact
- Exposure Limits: No specific occupational exposure limits but good industrial hygiene recommended
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated place, protected from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust generation; use appropriate PPE including gloves and masks
5. Regulatory & Compliance Attributes
- Conforms to British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Complies with relevant pharmaceutical regulatory requirements including ICH guidelines
6. Environmental & Health Impact
- Biodegradability: Limited data; sulfonamides generally degrade under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, lab coat, and dust mask recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash affected area with soap and water; discontinue use if irritation occurs
- Eye Contact: Flush with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice immediately
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Doxycycline Hyclate BP
Doxycycline Hyclate BP is a broad-spectrum, semisynthetic tetracycline-class antibiotic available as the hemihydrate salt form of doxycycline. It is widely used in pharmaceutical formulations due to its high bioavailability, broad antibacterial activity, and favorable pharmacokinetic profile. The compound exhibits bacteriostatic action by inhibiting protein synthesis in susceptible bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms as well as atypical pathogens. It is typically supplied as a fine, white to off-white crystalline powder soluble in water and suitable for oral and parenteral dosage forms.
Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Ivermectin BP Vet
Ivermectin BP Vet is a potent, broad-spectrum antiparasitic agent widely used in veterinary medicine. It belongs to the avermectin family and works by disrupting nerve and muscle function in parasites, leading to paralysis and death. Ivermectin is highly effective against a range of internal and external parasites, including gastrointestinal worms, lungworms, mites, lice, and certain ticks. Available in oral, injectable, and topical forms, it is trusted for use in livestock, poultry, and companion animals. Its reliable efficacy, wide safety margin, and ease of administration make it an essential treatment in animal health and parasite control programs.
Mepyramine Maleate BP
Mepyramine Maleate BP is an antihistamine drug commonly used to relieve allergic symptoms such as hay fever, urticaria, and other allergic reactions. It works by blocking histamine H1 receptors, reducing allergic responses like itching, swelling, and redness. This compound is a white or off-white crystalline powder, soluble in water and alcohol, widely used in pharmaceutical formulations including tablets, creams, and injectables.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Miconazole Nitrate BP
Miconazole Nitrate BP is a high-purity, pharmaceutical-grade antifungal agent conforming to British Pharmacopoeia (BP) specifications. It is widely used in the formulation of topical and oral pharmaceutical products for the treatment of fungal infections caused by dermatophytes and yeasts, including Candida species. Miconazole Nitrate functions by inhibiting the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to cell death.
This white to off-white crystalline powder is highly effective and exhibits broad-spectrum antifungal and some antibacterial activity. It is commonly utilized in creams, ointments, powders, and gel formulations.
Norfloxacin
Norfloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic used primarily to treat bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Norfloxacin is effective against various Gram-negative and some Gram-positive bacteria and is commonly used in urinary tract infections, prostatitis, and gastroenteritis.
