Sulphamethoxazole BP

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Sulphamethoxazole BP is a synthetic sulfonamide antibiotic widely used in human and veterinary medicine for treating bacterial infections. It acts by inhibiting bacterial synthesis of dihydrofolic acid, thereby preventing bacterial growth. It is commonly combined with trimethoprim for synergistic effects against a broad spectrum of bacteria. The British Pharmacopoeia (BP) grade guarantees pharmaceutical purity and quality, making it suitable for formulation into tablets, suspensions, and other dosage forms.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Antibacterial Agent, Pharmaceutical industry, Sulfamethoxazole BP, Sulfonamide Antibiotic, Sulphamethoxazole, White to off-white powder

Description

Table of Contents

Sulphamethoxazole BP

Primary Uses

Human Medicine

Antibacterial Agent: Used to treat urinary tract infections, respiratory tract infections, gastrointestinal infections, and certain opportunistic infections (e.g., Pneumocystis pneumonia).
Combination Therapy: Frequently combined with trimethoprim (co-trimoxazole) to enhance antibacterial efficacy.

Veterinary Medicine

Antimicrobial Agent: Used to treat bacterial infections in livestock and companion animals, including respiratory, urinary, and soft tissue infections.
Medicated Feeds: Included in veterinary feed additives to prevent and control bacterial diseases.

Secondary Uses

Research & Development

Pharmaceutical Studies: Used in drug formulation research and studies on antibiotic resistance.
Microbiological Research: Utilized in bacterial culture sensitivity testing.

Public Health

Prophylactic Use: Occasionally used for prophylaxis against certain infections in immunocompromised patients.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
Common/Trade Name: Sulphamethoxazole BP
CAS Number: 723-46-6
HS Code: 2941.20.00
Synonyms: Sulfamethoxazole, SMX

2. Physical & Chemical Properties

Physical State: White to off-white crystalline powder
Color & Odor: White; odorless or faint sulfur-like odor
Melting Point: 169–172 °C
Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents such as ethanol
Density: Approx. 1.4 g/cm³

3. Safety & Hazard Attributes

GHS Classification: May cause allergic skin reactions and hypersensitivity
Toxicity: Moderate toxicity; avoid prolonged exposure
Exposure Limits: No specific occupational limits; use proper industrial hygiene

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry, well-ventilated area protected from light and moisture
Container Type: Sealed HDPE or glass containers
Shelf Life: 24 months under proper storage conditions
Handling Precautions: Avoid dust; use gloves and masks to prevent inhalation and skin contact

5. Regulatory & Compliance Attributes

Complies with British Pharmacopoeia (BP) standards
Manufactured under Good Manufacturing Practices (GMP)
Meets pharmaceutical regulatory requirements for human and veterinary use

6. Environmental & Health Impact

Biodegradability: Limited biodegradability; degrades slowly under aerobic conditions
Ecotoxicity: Potentially harmful to aquatic organisms; avoid release into the environment
Bioaccumulation: Not significant

SAFETY HANDLING FEATURES

Safety Handling Precautions

PPE Required: Gloves, protective clothing, and dust masks recommended
Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
Storage Measures: Keep containers tightly closed and dry

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms occur
Skin Contact: Wash with soap and water; discontinue use if irritation develops
Eye Contact: Flush with water for 15 minutes; seek medical care if irritation persists
Ingestion: Rinse mouth; seek medical advice promptly

Firefighting Measures

Fire Hazards: Combustible solid
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides