Sulphamethoxazole BP micronised
Sulphamethoxazole BP Micronised is a fine, micronized form of sulphamethoxazole, a synthetic sulfonamide antibiotic used extensively in human and veterinary medicine. Micronization improves its dissolution rate and bioavailability, enhancing efficacy in oral and injectable formulations. This British Pharmacopoeia (BP) grade product ensures high purity and consistent particle size, making it ideal for pharmaceutical manufacturing.
Primary Uses
Human Medicine
Antibacterial Agent: Used in treatment of urinary tract infections, respiratory infections, gastrointestinal infections, and Pneumocystis pneumonia, often in combination with trimethoprim (co-trimoxazole).
Improved Formulations: Micronized powder enhances solubility and absorption in tablets, suspensions, and injectables.
Veterinary Medicine
Antimicrobial Agent: Used for bacterial infections in livestock and companion animals, including respiratory and urinary tract infections.
Medicated Feeds and Injectables: Ideal for veterinary formulations requiring enhanced bioavailability.
Secondary Uses
Pharmaceutical Research & Development
Formulation Development: Used to improve dissolution rates and bioavailability studies.
Microbiological Testing: Employed in bacterial sensitivity assays and antibiotic resistance research.
Public Health
Prophylaxis and Treatment: Used in immunocompromised patients to prevent opportunistic infections.
Basic Identification Attributes
Chemical Name (IUPAC): 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
Common/Trade Name: Sulphamethoxazole BP Micronised
CAS Number: 723-46-6
HS Code: 2941.20.00
Synonyms: Sulfamethoxazole micronized, SMX micronized
Physical & Chemical Properties
Physical State: Fine, white to off-white crystalline powder
Color & Odor: White; faint sulfur-like odor
Particle Size: Micronized for enhanced dissolution (typically <10 microns)
Melting Point: 169–172 °C
Solubility: Slightly soluble in water; soluble in alkaline solutions and ethanol
Density: Approx. 1.4 g/cm³
Safety & Hazard Attributes
GHS Classification: May cause allergic skin reactions and hypersensitivity
Toxicity: Moderate toxicity; avoid prolonged exposure
Exposure Limits: No specific occupational limits; observe good industrial hygiene
Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated area away from light and moisture
Container Type: Sealed airtight containers or drums
Shelf Life: 24 months under recommended conditions
Handling Precautions: Minimize dust generation; use gloves and dust masks
Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards
Manufactured under Good Manufacturing Practices (GMP)
Suitable for human and veterinary pharmaceutical use
Environmental & Health Impact
Biodegradability: Limited; degrades slowly under aerobic conditions
Ecotoxicity: Potentially harmful to aquatic life; avoid environmental discharge
Bioaccumulation: Not significant
PPE Required: Gloves, protective clothing, and dust masks recommended
Handling Guidelines: Use adequate ventilation to control dust exposure
Storage Measures: Keep containers tightly sealed and dry
First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water
Eye Contact: Flush with water for 15 minutes; seek medical help if irritation continues
Ingestion: Rinse mouth; obtain medical advice if necessary
Firefighting Measures
Fire Hazards: Combustible solid
Extinguishing Media: Water spray, foam, dry chemical, or COâ‚‚ extinguishers
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides