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Sulphamethoxazole BP micronised

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Sulphamethoxazole BP Micronised is a fine, micronized form of sulphamethoxazole, a synthetic sulfonamide antibiotic used extensively in human and veterinary medicine. Micronization improves its dissolution rate and bioavailability, enhancing efficacy in oral and injectable formulations. This British Pharmacopoeia (BP) grade product ensures high purity and consistent particle size, making it ideal for pharmaceutical manufacturing.

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Description

Primary Uses
Human Medicine
Antibacterial Agent: Used in treatment of urinary tract infections, respiratory infections, gastrointestinal infections, and Pneumocystis pneumonia, often in combination with trimethoprim (co-trimoxazole).

Improved Formulations: Micronized powder enhances solubility and absorption in tablets, suspensions, and injectables.

Veterinary Medicine
Antimicrobial Agent: Used for bacterial infections in livestock and companion animals, including respiratory and urinary tract infections.

Medicated Feeds and Injectables: Ideal for veterinary formulations requiring enhanced bioavailability.

 

Secondary Uses
Pharmaceutical Research & Development
Formulation Development: Used to improve dissolution rates and bioavailability studies.

Microbiological Testing: Employed in bacterial sensitivity assays and antibiotic resistance research.

Public Health
Prophylaxis and Treatment: Used in immunocompromised patients to prevent opportunistic infections.

PRODUCT KEY FEATURES

Basic Identification Attributes
Chemical Name (IUPAC): 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide

Common/Trade Name: Sulphamethoxazole BP Micronised

CAS Number: 723-46-6

HS Code: 2941.20.00

Synonyms: Sulfamethoxazole micronized, SMX micronized

 

Physical & Chemical Properties
Physical State: Fine, white to off-white crystalline powder

Color & Odor: White; faint sulfur-like odor

Particle Size: Micronized for enhanced dissolution (typically <10 microns)

Melting Point: 169–172 °C

Solubility: Slightly soluble in water; soluble in alkaline solutions and ethanol

Density: Approx. 1.4 g/cm³

 

Safety & Hazard Attributes
GHS Classification: May cause allergic skin reactions and hypersensitivity

Toxicity: Moderate toxicity; avoid prolonged exposure

Exposure Limits: No specific occupational limits; observe good industrial hygiene

 

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated area away from light and moisture

Container Type: Sealed airtight containers or drums

Shelf Life: 24 months under recommended conditions

Handling Precautions: Minimize dust generation; use gloves and dust masks

 

Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards

Manufactured under Good Manufacturing Practices (GMP)

Suitable for human and veterinary pharmaceutical use

 

Environmental & Health Impact
Biodegradability: Limited; degrades slowly under aerobic conditions

Ecotoxicity: Potentially harmful to aquatic life; avoid environmental discharge

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

PPE Required: Gloves, protective clothing, and dust masks recommended

Handling Guidelines: Use adequate ventilation to control dust exposure

Storage Measures: Keep containers tightly sealed and dry

 

First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if symptoms develop

Skin Contact: Wash thoroughly with soap and water

Eye Contact: Flush with water for 15 minutes; seek medical help if irritation continues

Ingestion: Rinse mouth; obtain medical advice if necessary

 

Firefighting Measures
Fire Hazards: Combustible solid

Extinguishing Media: Water spray, foam, dry chemical, or COâ‚‚ extinguishers

Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides

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