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Sulphamethoxazole BP micronised
Sulphamethoxazole BP Micronised is a fine, micronized form of sulphamethoxazole, a synthetic sulfonamide antibiotic used extensively in human and veterinary medicine. Micronization improves its dissolution rate and bioavailability, enhancing efficacy in oral and injectable formulations. This British Pharmacopoeia (BP) grade product ensures high purity and consistent particle size, making it ideal for pharmaceutical manufacturing.
Sulphamethoxazole BP micronised
Primary Uses
- Human Medicine
- Antibacterial Agent: Used in treatment of urinary tract infections, respiratory infections, gastrointestinal infections, and Pneumocystis pneumonia, often in combination with trimethoprim (co-trimoxazole).
- Improved Formulations: Micronized powder enhances solubility and absorption in tablets, suspensions, and injectables.
- Veterinary Medicine
- Antimicrobial Agent: Used for bacterial infections in livestock and companion animals, including respiratory and urinary tract infections.
- Medicated Feeds and Injectables: Ideal for veterinary formulations requiring enhanced bioavailability.
Secondary Uses
- Pharmaceutical Research & Development
- Formulation Development: Used to improve dissolution rates and bioavailability studies.
- Microbiological Testing: Employed in bacterial sensitivity assays and antibiotic resistance research.
- Public Health
- Prophylaxis and Treatment: Used in immunocompromised patients to prevent opportunistic infections.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
- Common/Trade Name: Sulphamethoxazole BP Micronised
- CAS Number: 723-46-6
- HS Code: 2941.20.00
- Synonyms: Sulfamethoxazole micronized, SMX micronized
2. Physical & Chemical Properties
- Physical State: Fine, white to off-white crystalline powder
- Color & Odor: White; faint sulfur-like odor
- Particle Size: Micronized for enhanced dissolution (typically <10 microns)
- Melting Point: 169–172 °C
- Solubility: Slightly soluble in water; soluble in alkaline solutions and ethanol
- Density: Approx. 1.4 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic skin reactions and hypersensitivity
- Toxicity: Moderate toxicity; avoid prolonged exposure
- Exposure Limits: No specific occupational limits; observe good industrial hygiene
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area away from light and moisture
- Container Type: Sealed airtight containers or drums
- Shelf Life: 24 months under recommended conditions
- Handling Precautions: Minimize dust generation; use gloves and dust masks
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Suitable for human and veterinary pharmaceutical use
6. Environmental & Health Impact
- Biodegradability: Limited; degrades slowly under aerobic conditions
- Ecotoxicity: Potentially harmful to aquatic life; avoid environmental discharge
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, protective clothing, and dust masks recommended
- Handling Guidelines: Use adequate ventilation to control dust exposure
- Storage Measures: Keep containers tightly sealed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash thoroughly with soap and water
- Eye Contact: Flush with water for 15 minutes; seek medical help if irritation continues
- Ingestion: Rinse mouth; obtain medical advice if necessary
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
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