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Tylosin Tartrate

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Tylosin Tartrate is a water-soluble macrolide antibiotic derived from Streptomyces fradiae, primarily used in veterinary medicine. It is the tartrate salt form of tylosin, enhancing its solubility and making it ideal for administration via drinking water or injectable solutions. Tylosin Tartrate is active against a wide range of Gram-positive bacteria and some Gram-negative organisms, as well as Mycoplasma spp. It is particularly effective for treating respiratory, gastrointestinal, and reproductive infections in livestock and poultry.

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Description

Primary Uses
Veterinary Medicine

Poultry:

Treatment and prevention of chronic respiratory disease (CRD) caused by Mycoplasma gallisepticum.

Controls infectious sinusitis in turkeys and synovitis caused by Mycoplasma synoviae.

Administered via drinking water or feed.

Swine:

Used for ileitis, swine dysentery, and enzootic pneumonia (caused by Mycoplasma hyopneumoniae and Brachyspira hyodysenteriae).

Often included in medicated feed or water.

Cattle:

Controls bovine respiratory disease complex (shipping fever) caused by Pasteurella, Mycoplasma, and Haemophilus species.

Also used for foot rot and metritis.

Sheep and Goats:

Treats respiratory infections and mycoplasma-related arthritis.

Companion Animals (off-label in some countries):

Sometimes used to treat chronic colitis or diarrhea in dogs and cats under veterinary supervision.

Aquaculture (where permitted)

Used against Mycoplasma-like organisms and secondary bacterial infections.

Secondary Uses
Prophylactic Use in Herds/Fluctuations

Administered during high-stress periods (transport, weaning, vaccination) to prevent outbreaks.

Growth Promotion (where legal)

Historically used in low doses as a feed additive to promote growth and improve feed efficiency, though now restricted in many countries.

Research & Microbiology

Used as a selective antibiotic in culture media for isolating Mycoplasma species.

Applied in antimicrobial resistance studies.

 

 

PRODUCT KEY FEATURES

Chemical Name (IUPAC): Tylosin hydrogen tartrate

Common/Trade Name: Tylosin Tartrate

CAS Number: 1405-69-0

HS Code: 2941.90.00

Synonyms: Tylosin hydrogen tartrate, Macrolide antibiotic tartrate salt

 

Physical & Chemical Properties
Physical State: Powder

Color & Odor: Pale yellow to yellow; mild characteristic odor

Solubility: Freely soluble in water

Molecular Formula: C46H77NO17 · C4H6O6

Molecular Weight: ~1009.2 g/mol

pH (1% solution): 5.0–7.5

Loss on Drying: ≤ 5.0%

Assay (Potency): ≥ 800 µg/mg (potency based on tylosin activity)

 

Safety & Hazard Attributes
GHS Classification:

May cause respiratory or skin sensitization

Harmful if swallowed or inhaled in large quantities

Environmental hazard (to aquatic life with long-term effects)

Toxicity: Low toxicity to treated animals when used as directed

Irritation: May cause skin and eye irritation in handlers

Occupational Hazards: Allergic reactions (especially in individuals sensitive to macrolides)

 

Storage & Handling Attributes
Storage Conditions: Store below 25 °C in a dry place; protect from light and moisture

Container Type: Fiber drums or HDPE containers with inner liner

Shelf Life: 24–36 months under proper storage

Handling Precautions: Avoid inhalation of dust; wear protective gloves, eyewear, and mask

 

Regulatory & Compliance Attributes
Approved for veterinary use by FDA, EMA, WHO, and OIE (in various countries)

Not intended for human use

Must comply with maximum residue limits (MRLs) in food-producing animals

Complies with Good Manufacturing Practices (GMP) for veterinary pharmaceuticals

Use in accordance with Veterinary Prescription Regulations (region-specific)

 

Environmental & Health Impact
Biodegradability: Biodegradable under normal environmental conditions

Ecotoxicity: Potential impact on soil and aquatic microbiota if improperly disposed

Bioaccumulation: Low potential

Resistance Risk: May contribute to antimicrobial resistance if overused or misused

SAFETY HANDLING PRECAUTIONS

PPE Required: Gloves, dust mask, safety goggles

Handling Guidelines: Avoid generation of dust; use in well-ventilated areas

Storage Measures: Keep container tightly closed and dry

 

First Aid Measures
Inhalation: Move to fresh air; seek medical attention if symptoms persist

Skin Contact: Wash with soap and water

Eye Contact: Rinse with plenty of water; get medical help if irritation continues

Ingestion: Rinse mouth; consult a veterinarian or poison control if large quantities are consumed

 

Firefighting Measures
Fire Hazards: Not highly flammable but combustible in powder form

Extinguishing Media: Use water spray, foam, dry chemical, or CO₂

Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides

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