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Trimethoprim BP Micronised
Trimethoprim BP Micronised is a high-purity, fine powdered form of trimethoprim, an antibiotic used primarily for its bacteriostatic properties. The micronisation process enhances its solubility and bioavailability, making it more effective in pharmaceutical formulations. Trimethoprim acts by inhibiting bacterial dihydrofolate reductase, thereby preventing bacterial DNA synthesis and growth. It is widely used alone or in combination therapies to treat a variety of bacterial infections.
Trimethoprim BP Micronised
Primary Uses
- Pharmaceutical Industry:
- Active pharmaceutical ingredient (API) in oral tablets, suspensions, and injectable formulations targeting urinary tract infections (UTIs), respiratory tract infections, and other bacterial infections.
- Used in combination with sulfamethoxazole (co-trimoxazole) for synergistic antibacterial effect.
Secondary Uses
- Veterinary Medicine:
- Incorporated in veterinary antibiotic formulations to treat bacterial infections in livestock and companion animals.
- Research & Development:
- Utilized in pharmaceutical research for developing new antibacterial drugs and formulations.
1. Basic Key Attributes
- Chemical Name (IUPAC): 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
- Common/Trade Name: Trimethoprim BP Micronised
- CAS Number: 738-70-5
- HS Code: 2934.99.90
- Synonyms: Trimethoprim, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
2. Physical & Chemical Properties
- Physical State: Fine crystalline powder
- Color & Odor: White to off-white; odorless
- Particle Size: Micronised to enhance solubility and bioavailability
- Melting Point: 199–201 °C
- Solubility: Slightly soluble in water; soluble in alcohol and organic solvents
- Purity: Complies with British Pharmacopoeia (BP) standards
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal handling
- Toxicity: Low toxicity but may cause hypersensitivity or allergic reactions
- Exposure Limits: Follow pharmaceutical industry safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated place away from light and moisture
- Container Type: Sealed, moisture-proof containers such as HDPE drums or bottles
- Shelf Life: Typically 24 months under recommended storage conditions
- Handling Precautions: Avoid inhalation of dust; use appropriate PPE including masks and gloves
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP) ensuring pharmaceutical-grade quality
- Registered with relevant regulatory bodies for pharmaceutical use
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable; follow waste disposal regulations
- Ecotoxicity: Potentially harmful to aquatic organisms; avoid release into environment
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Dust mask, gloves, and eye protection recommended during handling
- Handling Guidelines: Use in well-ventilated areas; avoid dust generation
- Storage Measures: Keep containers tightly closed and protected from moisture
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash thoroughly with soap and water
- Eye Contact: Rinse eyes with plenty of water; seek medical advice if irritation persists
- Ingestion: Rinse mouth; seek immediate medical attention
Firefighting Measures
- Fire Hazards: May burn but not easily ignitable
- Extinguishing Media: Use water spray, foam, or dry chemical extinguisher
- Hazardous Combustion Products: Carbon oxides and nitrogen oxides
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