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Vitamin B3 (Nicotinamide)
Vitamin B3 Nicotinamide, also known as Niacinamide, is a water-soluble amide form of vitamin B3. It plays a crucial role in cellular energy production and DNA repair by serving as a precursor for coenzymes NAD and NADP. Nicotinamide is preferred in many pharmaceutical and cosmetic applications due to its stability and lower side-effect profile compared to niacin. It is widely used in pharmaceuticals, nutraceuticals, cosmetics, and food fortification.
Vitamin B3 (Nicotinamide)
Primary Uses
- Pharmaceutical Industry
- Nutritional Supplement: Used to treat and prevent vitamin B3 deficiency and pellagra without causing flushing side effects.
- Therapeutic Agent: Applied in skin-related treatments and as an adjunct in managing certain neurological and metabolic disorders.
- Cosmetic Industry
- Skin Care Ingredient: Utilized in creams, lotions, and serums for its anti-inflammatory, anti-aging, and skin-brightening properties.
- Food & Beverage Industry
- Fortification Agent: Added to fortified foods and dietary supplements to improve nutritional content.
Secondary Uses
- Animal Nutrition
- Feed Supplement: Used to enhance growth, metabolism, and overall health in livestock.
- Research & Development
- Utilized in biomedical research on metabolism, skin health, and vitamin therapy.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Pyridine-3-carboxamide
- Common/Trade Name: Nicotinamide, Niacinamide, Vitamin B3
- CAS Number: 98-92-0
- HS Code: 2922.49.00
- Synonyms: Niacinamide, Nicotinic acid amide
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: White; odorless
- Solubility: Soluble in water; slightly soluble in alcohol
- Melting Point: 128–131 °C
- Density: Approx. 1.4 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal conditions
- Toxicity: Low toxicity; safe within recommended doses
- Exposure Limits: No established occupational exposure limits
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area protected from light and moisture
- Container Type: Sealed containers or bags
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust formation; minimize exposure to moisture
5. Regulatory & Compliance Attributes
- Complies with USP, BP, and other pharmacopeial standards
- Manufactured under GMP to ensure consistent quality and safety
- Approved for use in pharmaceuticals, dietary supplements, cosmetics, and food fortification
- Meets international regulatory requirements
6. Environmental & Health Impact
- Biodegradability: Biodegradable and environmentally safe
- Ecotoxicity: Low environmental hazard
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended
- Handling Guidelines: Use adequate ventilation; avoid inhalation of dust
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if irritation occurs
- Skin Contact: Wash with soap and water
- Eye Contact: Flush with water for 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; obtain medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Water spray, foam, or dry chemical extinguishers
- Hazardous Combustion Products: Carbon oxides and nitrogen oxides may form upon combustion
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