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Dicyclomine Hydrochloride (Dicyclomine HCL)
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Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.
Description
Dicyclomine Hydrochloride (Dicyclomine HCL) Uses
Primary UsesÂ
- Gastrointestinal Disorders
- Irritable Bowel Syndrome (IBS): Relieves abdominal cramping and pain by relaxing the smooth muscles of the gut.
- Functional Bowel Disorders: Treats spasms in conditions like spastic colon and diverticulitis.
- Gastrointestinal Spasms: Manages spasms associated with colitis, enteritis, and other inflammatory bowel diseases.
- Preoperative Medication
- Used to reduce secretions and relax smooth muscles before surgery or diagnostic procedures involving the gastrointestinal tract.
- Treatment of Colic
- Relieves intestinal colic and discomfort in adults and sometimes pediatric patients.
Secondary UsesÂ
- Urinary Bladder Disorders
- Sometimes used off-label to relieve bladder spasms in urinary tract dysfunctions.
- Adjunct Therapy in Gastrointestinal Procedures
- Administered to ease discomfort during endoscopy or radiological imaging by reducing bowel motility.
- Research Applications
Utilized in pharmacological studies focusing on muscarinic receptor antagonists and smooth muscle physiology.
PRODUCT KEY FEATURES
- Basic Identification Attributes
- Chemical Name (IUPAC): 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride
- Common/Trade Name: Dicyclomine Hydrochloride, Dicycloverine
- CAS Number: 67-92-5
- HS Code: 2924.99.90
- Molecular Formula: C19H35NO2·HCl
- Synonyms:
- Dicycloverine Hydrochloride
- Dicyclomine HCl
- Bentyl (brand name)
- Physical & Chemical Properties
- Physical State: White crystalline powder
- Solubility: Soluble in water and alcohol
- Melting Point: 164–167°C
- Stability: Stable under normal storage conditions
- Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous; handle as pharmaceutical chemical
- Toxicity: Low acute toxicity, but overdose can cause anticholinergic symptoms
- Exposure Limits: Follow pharmaceutical handling guidelines
- Storage & Handling
- Store in a cool, dry, well-ventilated area away from light
- Shelf Life: Typically 2–3 years under proper conditions
- Regulatory & Compliance
- Approved by FDA and other global regulatory bodies for pharmaceutical use
- Included in various pharmacopeias (BP, USP)
- Environmental & Health Impact
- Low environmental persistence
Not considered ecotoxic or bioaccumulative
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
PPE Required:
- Gloves (nitrile or latex)
- Safety goggles
- Lab coat or protective apron
Handling Guidelines:
- Avoid inhalation of powder and dust
- Avoid skin and eye contact
- Use in a well-ventilated area or under fume hood
- Follow GMP and pharmaceutical manufacturing practices
Storage Measures:
- Keep container tightly closed
- Store away from moisture and direct sunlight
- Store in a cool, dry place
Hygiene Practices:
- Wash hands thoroughly after handling
- Do not eat, drink, or smoke while handling product
- Avoid cross-contamination with other chemicals
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms persist
- Skin Contact: Wash with soap and water; consult physician if irritation occurs
- Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; seek medical advice
- Ingestion: Rinse mouth with water; seek medical attention if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible at high temperatures
- Extinguishing Media: Water spray, foam, dry chemical, or COâ‚‚
- Special Precautions: Avoid inhaling smoke and combustion products
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