Oxytetracycline HCL BP

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Oxytetracycline HCL BP is a broad-spectrum tetracycline antibiotic used in human and veterinary medicine. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thus preventing the growth and multiplication of susceptible bacteria. Oxytetracycline HCL is effective against a wide range of Gram-positive and Gram-negative bacteria, as well as some protozoa. It is commonly employed to treat respiratory, urinary, and skin infections, and is also used extensively in veterinary applications to control infectious diseases in livestock and poultry.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Antibiotic Medication, Broad-spectrum antibiotic, Oxytetracycline Hydrochloride, Pharmaceutical API, Tetracycline Antibiotic

Description

Table of Contents

Oxytetracycline HCL BP

Primary Uses

Human Medicine
- Treatment of respiratory tract infections (bronchitis, pneumonia).
- Management of urinary tract infections (UTIs).
- Treatment of skin and soft tissue infections.
- Therapy for certain sexually transmitted infections such as chlamydia.
- Used in acne treatment due to its anti-inflammatory properties.
Veterinary Medicine
- Treatment of bacterial infections in livestock (cattle, sheep, goats).
- Control of respiratory diseases in poultry and swine.
- Management of mastitis in dairy animals.
- Used to treat enteric infections and wound infections in animals.
Agricultural Applications
- Occasionally used in aquaculture to control bacterial infections in fish.

Secondary Uses

Protozoal Infections
- Effective against certain protozoa such as Rickettsia species and Mycoplasma.
Periodontal Therapy
- Used adjunctively in treatment of periodontal (gum) disease.
Topical Formulations
- Incorporated in ointments and creams for localized bacterial infections and skin conditions.
Research Applications
- Used in microbiological studies as a selective antibiotic.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (4S,4aS,5aR,6S,12aS)-4-(Dimethylamino)-3,5,6,10,11,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
Common/Trade Name: Oxytetracycline Hydrochloride
CAS Number: 2058-46-0
HS Code: 2941.40.00
Synonyms: OTC HCL; Terramycin HCL; Oxytet HCL

2. Physical & Chemical Properties

Physical State: Fine crystalline powder
Color & Odor: Yellow to orange-yellow; odorless
Solubility: Freely soluble in water and dilute acids; slightly soluble in alcohol
Melting Point: 205–207 °C (decomposes)

3. Safety & Hazard Attributes

GHS Classification: Harmful if swallowed; may cause skin and respiratory irritation
Toxicity: Low to moderate toxicity; use with caution and according to dosage instructions
Exposure Limits: Use protective equipment to avoid inhalation and skin contact

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place, protected from light
Container Type: Supplied in airtight containers or bottles
Shelf Life: Typically 2–3 years if stored properly
Handling Precautions: Avoid dust inhalation and prolonged skin contact; use gloves and mask if necessary

5. Regulatory & Compliance Attributes

Complies with BP (British Pharmacopoeia), USP, and other pharmacopeial standards
Registered for human and veterinary pharmaceutical use
Complies with national and international antibiotic regulations

6. Environmental & Health Impact

Biodegradability: Moderately biodegradable
Ecotoxicity: Avoid release into waterways; may be toxic to aquatic organisms
Bioaccumulation: Not significantly bioaccumulative
Carcinogenicity/Mutagenicity: No known carcinogenic effects; standard antibiotic precautions apply

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, lab coat, and respiratory protection recommended during handling
Handling Guidelines: Work in well-ventilated areas; avoid inhaling dust and direct skin or eye contact
Storage Measures: Keep containers tightly sealed and away from incompatible substances

First Aid Measures

Inhalation: Move to fresh air; seek medical advice if symptoms develop
Skin Contact: Wash thoroughly with soap and water; seek medical attention if irritation persists
Eye Contact: Rinse immediately with plenty of water for 15 minutes; consult a physician if irritation continues
Ingestion: Do not induce vomiting; seek immediate medical attention

Firefighting Measures

Fire Hazards: Non-flammable
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers as appropriate
Special Precautions: Use standard protective firefighting equipment
Hazardous Combustion Products: May emit toxic fumes of nitrogen oxides and carbon oxides under fire conditions