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Prednisolone Sodium Phosphate
Prednisolone Sodium Phosphate is a water-soluble ester of prednisolone, a synthetic glucocorticoid steroid with potent anti-inflammatory and immunosuppressive effects. Its enhanced solubility makes it suitable for injectable formulations and rapid systemic action. It is commonly used to treat various inflammatory, allergic, and autoimmune conditions, offering effective modulation of immune responses and inflammation.
Prednisolone Sodium Phosphate
Primary Uses
- Pharmaceuticals
- Used in intravenous and intramuscular injections for rapid treatment of acute inflammatory and allergic conditions such as asthma exacerbations, severe allergic reactions, and shock.
- Administered in oral and parenteral formulations for autoimmune diseases like rheumatoid arthritis and lupus.
- Utilized in ophthalmic preparations for inflammatory eye diseases.
- Veterinary Medicine
- Used in veterinary injections to manage inflammation and immune-mediated diseases in animals.
Secondary Uses
- Clinical Research
- Used in pharmacokinetic and pharmacodynamic studies involving glucocorticoids.
- Diagnostic Applications
- Employed in testing adrenal gland function due to its glucocorticoid activity.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Disodium (11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-phosphate
- Common/Trade Name: Prednisolone Sodium Phosphate
- CAS Number: 125-02-0
- HS Code: 2937.29
- Synonyms: Prednisolone phosphate disodium salt; Sodium prednisolone phosphate
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White to off-white; odorless
- Solubility: Highly soluble in water
- Melting Point: Approximately 260–265°C (decomposes)
- Stability: Stable under recommended storage conditions
3. Safety & Hazard Attributes
- GHS Classification: May cause skin and eye irritation; handle with care
- Toxicity: Moderate; requires medical supervision for use
- Exposure Limits: Follow occupational safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from moisture and light
- Container Type: Sealed glass or plastic containers
- Shelf Life: Typically 2–3 years
- Handling Precautions: Use gloves and protective clothing; avoid inhalation and contact
5. Regulatory & Compliance Attributes
- Complies with pharmacopeial standards such as USP, BP, and EP
- Approved for use in injectable and oral pharmaceutical formulations
6. Environmental & Health Impact
- Biodegradability: Organic compound; biodegradable under environmental conditions
- Ecotoxicity: Low when disposed properly
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, goggles, and lab coat recommended
- Handling Guidelines: Avoid inhalation, ingestion, and skin contact; use in well-ventilated areas
- Storage Measures: Keep containers tightly closed and protected from moisture
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical attention if irritation persists
- Ingestion: Rinse mouth; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Combustible under fire conditions
- Extinguishing Media: Water spray, foam, dry chemical, or CO₂
- Special Precautions: Use self-contained breathing apparatus
- Hazardous Combustion Products: Carbon oxides and toxic fumes
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