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Aminosidine Sulphate

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Aminosidine Sulphate USP, also known as Paromomycin Sulphate, is an aminoglycoside antibiotic primarily used to treat parasitic infections and certain bacterial infections. It is a white or off-white crystalline powder, highly soluble in water, and typically administered orally or topically. It works by inhibiting protein synthesis in susceptible microorganisms, thereby exerting a bactericidal and antiparasitic effect. Aminosidine Sulphate is commonly employed in treating intestinal amoebiasis, leishmaniasis, and infections caused by gram-negative bacteria. Its inclusion in the United States Pharmacopeia (USP) signifies compliance with strict quality and purity standards for pharmaceutical use.

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Categories: Antibiotics, Active Pharmaceutical Ingredients (APIs) Tags: Aminosidine sulphate USP, Antibiotic active ingredient, Human pharmaceutical manufacturing, Veterinary medicine API

Description

Table of Contents

Aminosidine Sulphate

Primary Uses

Pharmaceutical & Medical Applications

Used as an oral antibiotic for treating intestinal parasitic infections such as amoebiasis and giardiasis.
Administered in the treatment of visceral and cutaneous leishmaniasis, especially in endemic regions.
Utilized to treat certain bacterial infections caused by gram-negative bacteria, including those resistant to other antibiotics.
Used topically in some formulations to treat bacterial infections of the skin and mucous membranes.

Veterinary Medicine

Used to treat parasitic infections in animals, particularly protozoal infections affecting the gastrointestinal tract.

Secondary Uses

Research & Laboratory Use

Employed in microbiological and pharmacological studies related to aminoglycoside antibiotics.
Occasionally used as a model drug in drug delivery and resistance mechanism research.

Formulations & Compounded Medications

Incorporated into combination therapies with other antibiotics or antiparasitic agents for enhanced efficacy.
Sometimes used in veterinary topical ointments or sprays for local infections.

Additional information

PACK SIZE	25kg

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (2R,3R,4R,5S,6R)-5-Amino-6-[(1R,2R,3R,4R,5S)-4,5-diamino-2-hydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol sulfate
Common/Trade Names: Aminosidine Sulphate, Paromomycin Sulphate
CAS Number: 1263-89-4
HS Code: 2941.90.90
Molecular Formula: C23H46N4O14·H2SO4
Synonyms: Paromomycin Sulphate, Aminosidine Sulfate USP

2. Physical & Chemical Properties

Physical State: White to off-white crystalline powder
Color & Odor: White, odorless or faint odor
Melting Point: >230°C (decomposes)
Boiling Point: N/A (decomposes)
Density: ~1.6 g/cm³
Solubility: Highly soluble in water; practically insoluble in ethanol and organic solvents
pH Level: Slightly acidic to neutral in aqueous solution (~4.5–7)
Vapor Pressure: Negligible
Flash Point: Not applicable
Autoignition Temperature: N/A

3. Safety & Hazard Attributes

Hazard Class (GHS): Harmful if swallowed; may cause allergic skin reactions
NFPA Ratings: Health 2, Flammability 0, Reactivity 0
Exposure Limits: No established OSHA PEL; handle as pharmaceutical chemical
Reactivity: Stable under normal conditions
Incompatibilities: Strong oxidizers, acids, and bases

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place below 25°C, protected from moisture and light
Container Type: Sealed amber glass or plastic containers
Shelf Life: Typically 2-3 years under proper storage
Special Handling: Avoid inhalation, skin, and eye contact; use protective gloves and eyewear

5. Regulatory & Compliance Attributes

Regulatory Status: Listed in USP, approved for pharmaceutical use in many countries
Transportation: Not classified as hazardous for transport when properly packaged
Waste Disposal: Dispose of in compliance with pharmaceutical waste regulations

6. Environmental & Health Impact

Ecotoxicity: Low environmental toxicity; avoid release into waterways
Persistence: Biodegradable under environmental conditions
Carcinogenicity: No known carcinogenic effects
Biodegradability: Readily biodegradable

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE: Wear gloves, safety goggles, and protective clothing when handling powder or concentrated solutions.
Handling: Avoid inhalation of dust and direct skin or eye contact; use in a well-ventilated area or fume hood.
Storage: Keep container tightly closed; protect from moisture and heat.
Hygiene: Wash hands thoroughly after handling; avoid eating, drinking, or smoking during handling.

First Aid Measures

Inhalation: Move affected person to fresh air. Seek medical attention if breathing difficulty occurs.
Skin Contact: Wash skin thoroughly with soap and water. If irritation or allergic reaction develops, seek medical advice.
Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes. Seek medical help if irritation persists.
Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel. Seek immediate medical attention.

Firefighting Measures

Fire Hazards: Not flammable but may decompose under intense heat producing toxic fumes.
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher.
Precautions: Firefighters should use self-contained breathing apparatus due to potential hazardous decomposition products.