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Aminosidine Sulphate
Original price was: $ 3.21.$ 3.09Current price is: $ 3.09.
Aminosidine Sulphate USP, also known as Paromomycin Sulphate, is an aminoglycoside antibiotic primarily used to treat parasitic infections and certain bacterial infections. It is a white or off-white crystalline powder, highly soluble in water, and typically administered orally or topically. It works by inhibiting protein synthesis in susceptible microorganisms, thereby exerting a bactericidal and antiparasitic effect. Aminosidine Sulphate is commonly employed in treating intestinal amoebiasis, leishmaniasis, and infections caused by gram-negative bacteria. Its inclusion in the United States Pharmacopeia (USP) signifies compliance with strict quality and purity standards for pharmaceutical use.
Aminosidine Sulphate
Primary Uses
- Pharmaceutical & Medical Applications
- Used as an oral antibiotic for treating intestinal parasitic infections such as amoebiasis and giardiasis.
- Administered in the treatment of visceral and cutaneous leishmaniasis, especially in endemic regions.
- Utilized to treat certain bacterial infections caused by gram-negative bacteria, including those resistant to other antibiotics.
- Used topically in some formulations to treat bacterial infections of the skin and mucous membranes.
- Veterinary Medicine
- Used to treat parasitic infections in animals, particularly protozoal infections affecting the gastrointestinal tract.
Secondary Uses
- Research & Laboratory Use
- Employed in microbiological and pharmacological studies related to aminoglycoside antibiotics.
- Occasionally used as a model drug in drug delivery and resistance mechanism research.
- Formulations & Compounded Medications
- Incorporated into combination therapies with other antibiotics or antiparasitic agents for enhanced efficacy.
- Sometimes used in veterinary topical ointments or sprays for local infections.
| PACK SIZE | 25kg |
|---|
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2R,3R,4R,5S,6R)-5-Amino-6-[(1R,2R,3R,4R,5S)-4,5-diamino-2-hydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol sulfate
- Common/Trade Names: Aminosidine Sulphate, Paromomycin Sulphate
- CAS Number: 1263-89-4
- HS Code: 2941.90.90
- Molecular Formula: C23H46N4O14·H2SO4
- Synonyms: Paromomycin Sulphate, Aminosidine Sulfate USP
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: White, odorless or faint odor
- Melting Point: >230°C (decomposes)
- Boiling Point: N/A (decomposes)
- Density: ~1.6 g/cm³
- Solubility: Highly soluble in water; practically insoluble in ethanol and organic solvents
- pH Level: Slightly acidic to neutral in aqueous solution (~4.5–7)
- Vapor Pressure: Negligible
- Flash Point: Not applicable
- Autoignition Temperature: N/A
3. Safety & Hazard Attributes
- Hazard Class (GHS): Harmful if swallowed; may cause allergic skin reactions
- NFPA Ratings: Health 2, Flammability 0, Reactivity 0
- Exposure Limits: No established OSHA PEL; handle as pharmaceutical chemical
- Reactivity: Stable under normal conditions
- Incompatibilities: Strong oxidizers, acids, and bases
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place below 25°C, protected from moisture and light
- Container Type: Sealed amber glass or plastic containers
- Shelf Life: Typically 2-3 years under proper storage
- Special Handling: Avoid inhalation, skin, and eye contact; use protective gloves and eyewear
5. Regulatory & Compliance Attributes
- Regulatory Status: Listed in USP, approved for pharmaceutical use in many countries
- Transportation: Not classified as hazardous for transport when properly packaged
- Waste Disposal: Dispose of in compliance with pharmaceutical waste regulations
6. Environmental & Health Impact
- Ecotoxicity: Low environmental toxicity; avoid release into waterways
- Persistence: Biodegradable under environmental conditions
- Carcinogenicity: No known carcinogenic effects
- Biodegradability: Readily biodegradable
Safety Handling Precautions
- PPE: Wear gloves, safety goggles, and protective clothing when handling powder or concentrated solutions.
- Handling: Avoid inhalation of dust and direct skin or eye contact; use in a well-ventilated area or fume hood.
- Storage: Keep container tightly closed; protect from moisture and heat.
- Hygiene: Wash hands thoroughly after handling; avoid eating, drinking, or smoking during handling.
First Aid Measures
- Inhalation: Move affected person to fresh air. Seek medical attention if breathing difficulty occurs.
- Skin Contact: Wash skin thoroughly with soap and water. If irritation or allergic reaction develops, seek medical advice.
- Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes. Seek medical help if irritation persists.
- Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel. Seek immediate medical attention.
Firefighting Measures
- Fire Hazards: Not flammable but may decompose under intense heat producing toxic fumes.
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher.
- Precautions: Firefighters should use self-contained breathing apparatus due to potential hazardous decomposition products.
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