Betamethasone 17 Valerate BP

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Betamethasone 17 Valerate BP is a potent synthetic corticosteroid ester used primarily for its anti-inflammatory, antipruritic, and vasoconstrictive properties. It is commonly applied topically to treat a variety of skin conditions such as eczema, psoriasis, dermatitis, and allergic reactions. The valerate ester enhances the lipophilicity and skin penetration of betamethasone, improving its therapeutic efficacy. It is recognized in the British Pharmacopoeia (BP) for pharmaceutical standards and quality.

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Categories: Active Ingredient, Active Pharmaceutical Ingredients (APIs), Topical Steroids Tags: Anti-inflammatory steroid, Cream and ointment formulation, Dermatology medication, Pharmaceutical Raw Material, Prescription drug ingredient, Synthetic corticosteroid, Treatment for skin conditions

Description

Table of Contents

Primary Uses

Pharmaceutical & Dermatological Uses

Used topically to treat inflammatory skin conditions including eczema, psoriasis, and contact dermatitis.
Alleviates symptoms such as redness, itching, swelling, and discomfort caused by allergic reactions and insect bites.
Employed in corticosteroid formulations like creams, ointments, lotions, and gels for localized anti-inflammatory effect.
Often used as a second-line treatment for moderate to severe dermatological disorders where mild corticosteroids are ineffective.

Veterinary Medicine

Used in veterinary topical treatments for inflammatory skin conditions in animals under veterinary supervision.

Secondary Uses

Occasionally included in combination pharmaceutical products with antifungal or antibacterial agents for treating mixed infections with inflammatory symptoms.
Used in clinical research for studying corticosteroid effects and delivery systems in dermatology.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): (8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
Common/Trade Names: Betamethasone 17 Valerate, Betamethasone valerate, BMV
CAS Number: 2152-44-5
HS Code: 2937.29.00
Molecular Formula: C27H37FO6
Synonyms: Betamethasone valerate, Betamethasone 17-valerate, 17-Valerate ester of betamethasone

Physical & Chemical Properties

Physical State: White to off-white crystalline powder
Color & Odor: White or creamy, odorless or faint odor
Melting Point: 118–121°C
Solubility: Slightly soluble in water, soluble in alcohol, chloroform, and acetone
Stability: Stable under recommended storage; sensitive to light and moisture

Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous but may cause skin irritation or sensitization
NFPA Ratings: Health 2, Flammability 1, Reactivity 0
Exposure Limits: No specific occupational exposure limits established
Toxicity: Low systemic toxicity when used topically as directed; prolonged use may cause steroid-related side effects

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place, protected from light and moisture
Container Type: Airtight containers, usually amber glass or plastic tubes for formulations
Shelf Life: 2–3 years under proper conditions
Special Handling: Avoid exposure to heat, light, and moisture; use PPE to avoid direct skin contact with pure powder

Regulatory & Compliance Attributes

BP (British Pharmacopoeia): Officially recognized and monographed
FDA/EMA: Approved in many countries for topical corticosteroid formulations
Transportation: Not classified as hazardous
Waste Disposal: Dispose as pharmaceutical waste according to local regulations

Environmental & Health Impact

Ecotoxicity: Low environmental hazard when used properly
Persistence: Degrades in the environment, but prolonged exposure should be minimized
Carcinogenicity: Not classified as carcinogenic
Biodegradability: Moderately biodegradable

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE: Wear gloves, protective clothing, and eye protection when handling the pure chemical.
Avoid: Prolonged skin contact and inhalation of dust.
Ventilation: Work in well-ventilated areas.
Hygiene: Wash hands thoroughly after handling.

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs.
Eye Contact: Rinse with plenty of water for 15 minutes; seek medical attention if irritation persists.
Ingestion: Rinse mouth and seek medical advice.

Firefighting Measures

Fire Hazards: Combustible solid; may burn but not easily ignited.
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers.

Special Precautions: Firefighters should wear protective equipment and self-contained breathing apparatus.