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Calamine Powder USP
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Calamine Powder USP is a fine, light pink powder primarily composed of zinc oxide and a small percentage of ferric oxide, which gives it its characteristic pink color. It is an inorganic compound widely used in pharmaceutical and cosmetic formulations due to its soothing, antiseptic, and astringent properties. Calamine Powder is commonly applied topically to relieve itching, minor skin irritations, insect bites, rashes, and sunburn. It acts by forming a protective barrier on the skin, reducing inflammation and providing a mild cooling effect.
Description
Primary Uses
- Pharmaceuticals
- Used as a topical antipruritic agent to relieve itching and discomfort caused by eczema, poison ivy, insect bites, and other minor skin irritations.
- Incorporated into calamine lotion and powder formulations for soothing sunburns and mild burns.
- Acts as a mild antiseptic and protective agent in dermatological creams and ointments.
- Cosmetic & Personal Care
- Used in powders and body talcs to soothe irritated skin and absorb moisture.
- Included in formulations for baby powders and skin care products to reduce friction and irritation.
- Medical & Clinical
- Employed in wound care products as a protective and drying agent for minor cuts, abrasions, and weeping skin conditions.
- Used in combination with other actives in anti-itch and anti-inflammatory topical preparations.
Secondary Uses
- Veterinary Medicine
- Applied topically to animals for soothing skin irritations and minor wounds.
- Industrial Applications
- Used in some formulations as a pigment or functional additive in cosmetics and dermatological products.
PRODUCT KEY FEATURES
Basic Identification Attributes
- Chemical Name (IUPAC): Zinc oxide mixed with ferric oxide
- Common/Trade Names: Calamine Powder USP, Calamine Powder
- CAS Number: 8012-95-1 (Calamine mixture)
- HS Code: 3206.49.00
- Molecular Formula: Primarily ZnO with Fe2O3 traces
- Synonyms:
- Calamine
- Zinc Ferrite (when referring to the iron-containing compound)
- Calamine Pink Powder
- Calamine USP Grade
2. Physical & Chemical Properties
- Physical State: Fine powder
- Color & Odor: Light pink; odorless or very faint mineral odor
- Melting Point: Decomposes above 1975°C (zinc oxide)
- Boiling Point: Not applicable (inorganic solid)
- Density: Approx. 4.0 g/cm³
- Solubility: Insoluble in water; soluble in acids and alkalis
- pH: Slightly alkaline when suspended in water (~7.5–8.5)
- Stability: Chemically stable under normal conditions
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous under normal use
- NFPA Ratings:
- Health: 1
- Flammability: 0
- Reactivity: 0
- Exposure Limits: OSHA PEL for zinc oxide dust: 5 mg/m³ (respirable)
- Toxicity: Low toxicity; inhalation of dust may cause mild respiratory irritation
- Reactivity: Stable; avoid strong acids which may liberate zinc salts
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place in tightly sealed containers to avoid moisture uptake
- Container Type: Airtight containers, typically HDPE or glass jars
- Shelf Life: Typically 3–5 years if stored properly
- Special Handling: Avoid dust formation; use PPE to avoid inhalation and eye contact
5. Regulatory & Compliance Attributes
- Pharmacopoeia Compliance: Complies with USP, BP, and Ph. Eur. standards
- FDA Status: Approved as a Generally Recognized As Safe (GRAS) ingredient for topical use
- Transportation: Not regulated as hazardous material
- Waste Disposal: Dispose as non-hazardous solid waste per local regulations
6. Environmental & Health Impact
- Ecotoxicity: Minimal environmental hazard; zinc compounds may affect aquatic life at high concentrations
- Persistence: Inorganic and persistent in the environment
- Bioaccumulation: Not expected to bioaccumulate significantly
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: Not biodegradable; inert mineral powder
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
Personal Protective Equipment (PPE):
- Dust mask or respirator
- Gloves
- Protective goggles
- Lab coat or apron
Handling Measures:
- Avoid generating and inhaling dust
- Use local exhaust ventilation in powder handling areas
- Work in well-ventilated areas
Storage Measures:
- Keep containers tightly closed
- Protect from moisture and contamination
Hygiene Practices:
- Wash hands thoroughly after handling
- Avoid eating, drinking, or smoking during handling
First Aid Measures
- Inhalation: Move to fresh air; if irritation persists, seek medical attention
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; seek medical attention if irritation continues
- Ingestion: Rinse mouth; not expected to be harmful in small amounts; seek medical advice if large quantities ingested
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ as appropriate for surrounding fire
- Special Precautions: Firefighters should wear protective gear and self-contained breathing apparatus if necessary
Decomposition Products: None under normal fire conditions; may release zinc oxides at very high temperatures
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